Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Angiopoietin-like 4 Protein"'
Publikováno v:
Biomedical and Biotechnology Research Journal, Vol 5, Iss 3, Pp 276-280 (2021)
Background: The role of Lactobacillus casei on human health is well documented. However, little is known about their protein effects on food digestion. Therefore, in the present study, we aimed to investigate the efficacy of three proteins of L. case
Externí odkaz:
https://doaj.org/article/3eefb9f7eeb3458c8030cf120497f72e
Akademický článek
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Autor:
Angela Gonzalez Diaz-Faes, Alberto Vázquez Salvi Luis, Elena Gonzalez Lopez, Ricardo Batanero Maguregui, Montalbán Carrasco Coral, Teresa García-Unzueta María, Velasco de Cos Guillermo, Armando Guerra Ruiz, Alio Lavín Gómez Bernardo
Publikováno v:
Endocrine Abstracts.
Akademický článek
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Publikováno v:
Aging.
Malignant cancer may contain highly heterogeneous populations of cells, including stem-like cells which were resistant to chemotherapy agents, radiation, mechanical stress, and immune surveillance. The characterization of these specific subpopulation
Autor:
Charlotte C J R Michielsen, Sander Kersten, Philip M.M. Ruppert, Eric J. Hazebroek, Lydia A. Afman, Gunilla Olivecrona, Ali Pirayesh
Publikováno v:
Molecular Metabolism, Vol 40, Iss, Pp 101033-(2020)
Molecular Metabolism 40 (2020)
Molecular Metabolism
Molecular Metabolism, 40
Molecular Metabolism 40 (2020)
Molecular Metabolism
Molecular Metabolism, 40
Objective Studies in mice have shown that the decrease in lipoprotein lipase (LPL) activity in adipose tissue upon fasting is mediated by induction of the inhibitor ANGPTL4. Here, we aimed to validate this concept in humans by determining the effect
Autor:
Philip Scheltens, Charlotte E. Teunissen, Victor L. Thijssen, Ananya Chakraborty, Ruud D. Fontijn, Alwin Kamermans, Ed Aanhane, Bert van het Hof, Jack van Horssen, Kitty C. M. Castricum, Wiesje M. van der Flier, Helga E. de Vries
Publikováno v:
Chakraborty, A, Kamermans, A, van Het Hof, B, Castricum, K, Aanhane, E, van Horssen, J, Thijssen, V L, Scheltens, P, Teunissen, C E, Fontijn, R D, van der Flier, W M & de Vries, H E 2018, ' Angiopoietin like-4 as a novel vascular mediator in capillary cerebral amyloid angiopathy ', Brain : a journal of neurology, vol. 141, no. 12, pp. 3377-3388 . https://doi.org/10.1093/brain/awy274
Brain : a journal of neurology, 141(12), 3377-3388
Brain : a journal of neurology, 141(12), 3377-3388
Increasing evidence suggests that vascular dysfunction in the brain is associated with early stages of Alzheimer's disease. Amyloid-β deposition in the microvasculature of the brain, a process referred to as capillary cerebral amyloid angiopathy (ca
Autor:
Vassilis I. Zannis, Panagiotis Fotakis, Despina Sanoudou, Dimitris Kardassis, Dimitris Theofilatos, Efi Valanti
Publikováno v:
Metabolism. 87:36-47
Background High Density Lipoprotein (HDL) and its main protein component, apolipoprotein A-I (apoA-I), have numerous atheroprotective functions on various tissues including the endothelium. Therapies based on reconstituted HDL containing apoA-I (rHDL
Autor:
Damien Chua, Yinliang Li, Marco Lizwan, Wei Ren Tan, Nguan Soon Tan, Ziqiang Teo, Jonathan Wei Kiat Wee, Maegan Miang Kee Lim, Wilson Wen Bin Goh, Jen Chi Soong, Pengcheng Zhu
Publikováno v:
Molecular Cancer, Vol 17, Iss 1, Pp 1-8 (2018)
Molecular Cancer
Molecular Cancer
Overcoming multidrug resistance has always been a major challenge in cancer treatment. Recent evidence suggested epithelial-mesenchymal transition plays a role in MDR, but the mechanism behind this link remains unclear. We found that the expression o
Autor:
Teresa Tusié-Luna, Svati H. Shah, Wen-Jane Lee, Amit Khera, Gonçalo R. Abecasis, Olle Melander, Alan R. Shuldiner, Connor A. Emdin, Kari Stefansson, Jesper Gromada, Andrew P. Morris, Lee-Ming Chuang, Omri Gottesman, Lars G. Fritsche, Pradeep Natarajan, Marju Orho-Melander, Daniel F. Gudbjartsson, Anubha Mahajan, Marylyn D. Ritchie, William E. Kraus, Tooraj Mirshahi, Colm O'Dushlaine, Jason Flannick, Nicholas J. Wareham, Anne Tybjærg-Hansen, Anders Berg Wulff, Rashmi B. Prasad, Aris Baras, Jonas B. Nielsen, Valgerdur Steinthorsdottir, Yii-Der Ida Chen, Jerome I. Rotter, Lukas Habegger, Samantha N. Fetterolf, David Altshuler, Om Prakash Dwivedi, Tanya M. Teslovich, Cristen J. Willer, Luca A. Lotta, Andrew J. Murphy, Joseph B. Leader, Cristopher V. Van Hout, Christopher D. Still, Ola Hansson, David Birtwell, Alexander Lopez, Daniel J. Rader, John D. Overton, Anthony Marcketta, Patrick Sulem, Peter N. Benotti, Jose C. Florez, Lydia Coulter Kwee, David J. Carey, Oddgeir L. Holmen, Kristian Hveem, Leif Groop, Sekar Kathiresan, Viktoria Gusarova, Unnur Thorsteinsdottir, Cassandra M. Hartle, Uyenlinh L. Mirshahi, H. Lester Kirchner, Shannon Bruse, Robert A. Scott, Michael F. Murray, Marketa Sjögren, Jeffrey G. Reid, Aeron Small, Børge G. Nordestgaard, Amr H. Wardeh, Chad M. Brummett, Mark I. McCarthy, Frederick E. Dewey, David H. Ledbetter, John Penn, Ingrid B. Borecki, Scott M. Damrauer, Hilma Holm, Michael Boehnke, George D. Yancopoulos
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Gusarova, V, O'Dushlaine, C, Teslovich, T M, Benotti, P N, Mirshahi, T, Gottesman, O, Van Hout, C V, Murray, M F, Mahajan, A, Nielsen, J B, Fritsche, L, Wulff, A B, Gudbjartsson, D F, Sjögren, M, Emdin, C A, Scott, R A, Lee, W-J, Small, A, Kwee, L C, Dwivedi, O P, Prasad, R B, Bruse, S, Lopez, A E, Penn, J, Marcketta, A, Leader, J B, Still, C D, Kirchner, H L, Mirshahi, U L, Wardeh, A H, Hartle, C M, Habegger, L, Fetterolf, S N, Tusie-Luna, T, Morris, A P, Holm, H, Steinthorsdottir, V, Sulem, P, Thorsteinsdottir, U, Rotter, J I, Chuang, L-M, Damrauer, S, Birtwell, D, Brummett, C M, Khera, A V, Natarajan, P, Orho-Melander, M, Flannick, J, Lotta, L A, Willer, C J, Holmen, O L, Ritchie, M D, Ledbetter, D H, Murphy, A J, Borecki, I B, Reid, J G, Overton, J D, Hansson, O, Groop, L, Shah, S H, Kraus, W E, Rader, D J, Chen, Y-D I, Hveem, K, Wareham, N J, Kathiresan, S, Melander, O, Stefansson, K, Nordestgaard, B G, Tybjærg-Hansen, A, Abecasis, G R, Altshuler, D, Florez, J C, Boehnke, M, McCarthy, M I, Yancopoulos, G D, Carey, D J, Shuldiner, A R, Baras, A, Dewey, F E & Gromada, J 2018, ' Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes ', Nature Communications, vol. 9, no. 1, pp. 2252 . https://doi.org/10.1038/s41467-018-04611-z
Gusarova, V, O'Dushlaine, C, Teslovich, T M, Benotti, P N, Mirshahi, T, Gottesman, O, Van Hout, C V, Murray, M F, Mahajan, A, Nielsen, J B, Fritsche, L, Wulff, A B, Gudbjartsson, D F, Sjögren, M, Emdin, C A, Scott, R A, Lee, W J, Small, A, Kwee, L C, Dwivedi, O P, Prasad, R B, Bruse, S, Lopez, A E, Penn, J, Marcketta, A, Leader, J B, Still, C D, Kirchner, H L, Mirshahi, U L, Wardeh, A H, Hartle, C M, Habegger, L, Fetterolf, S N, Tusie-Luna, T, Morris, A P, Holm, H, Steinthorsdottir, V, Sulem, P, Thorsteinsdottir, U, Rotter, J I, Chuang, L M, Damrauer, S, Birtwell, D, Brummett, C M, Khera, A V, Natarajan, P, Orho-Melander, M, Flannick, J, Lotta, L A, Willer, C J, Holmen, O L, Ritchie, M D, Ledbetter, D H, Murphy, A J, Borecki, I B, Reid, J G, Overton, J D, Hansson, O, Groop, L, Shah, S H, Kraus, W E, Rader, D J, Chen, Y D I, Hveem, K, Wareham, N J, Kathiresan, S, Melander, O, Stefansson, K, Nordestgaard, B G, Tybjærg-Hansen, A, Abecasis, G R, Altshuler, D, Florez, J C, Boehnke, M, McCarthy, M I, Yancopoulos, G D, Carey, D J, Shuldiner, A R, Baras, A, Dewey, F E & Gromada, J 2018, ' Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes ', Nature Communications, vol. 9, no. 1, 2252 . https://doi.org/10.1038/s41467-018-04611-z
Nature Communications
Nature communications, vol 9, iss 1
Gusarova, V, O'Dushlaine, C, Teslovich, T M, Benotti, P N, Mirshahi, T, Gottesman, O, Van Hout, C V, Murray, M F, Mahajan, A, Nielsen, J B, Fritsche, L, Wulff, A B, Gudbjartsson, D F, Sjögren, M, Emdin, C A, Scott, R A, Lee, W-J, Small, A, Kwee, L C, Dwivedi, O P, Prasad, R B, Bruse, S, Lopez, A E, Penn, J, Marcketta, A, Leader, J B, Still, C D, Kirchner, H L, Mirshahi, U L, Wardeh, A H, Hartle, C M, Habegger, L, Fetterolf, S N, Tusie-Luna, T, Morris, A P, Holm, H, Steinthorsdottir, V, Sulem, P, Thorsteinsdottir, U, Rotter, J I, Chuang, L-M, Damrauer, S, Birtwell, D, Brummett, C M, Khera, A V, Natarajan, P, Orho-Melander, M, Flannick, J, Lotta, L A, Willer, C J, Holmen, O L, Ritchie, M D, Ledbetter, D H, Murphy, A J, Borecki, I B, Reid, J G, Overton, J D, Hansson, O, Groop, L, Shah, S H, Kraus, W E, Rader, D J, Chen, Y-D I, Hveem, K, Wareham, N J, Kathiresan, S, Melander, O, Stefansson, K, Nordestgaard, B G, Tybjærg-Hansen, A, Abecasis, G R, Altshuler, D, Florez, J C, Boehnke, M, McCarthy, M I, Yancopoulos, G D, Carey, D J, Shuldiner, A R, Baras, A, Dewey, F E & Gromada, J 2018, ' Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes ', Nature Communications, vol. 9, no. 1, pp. 2252 . https://doi.org/10.1038/s41467-018-04611-z
Gusarova, V, O'Dushlaine, C, Teslovich, T M, Benotti, P N, Mirshahi, T, Gottesman, O, Van Hout, C V, Murray, M F, Mahajan, A, Nielsen, J B, Fritsche, L, Wulff, A B, Gudbjartsson, D F, Sjögren, M, Emdin, C A, Scott, R A, Lee, W J, Small, A, Kwee, L C, Dwivedi, O P, Prasad, R B, Bruse, S, Lopez, A E, Penn, J, Marcketta, A, Leader, J B, Still, C D, Kirchner, H L, Mirshahi, U L, Wardeh, A H, Hartle, C M, Habegger, L, Fetterolf, S N, Tusie-Luna, T, Morris, A P, Holm, H, Steinthorsdottir, V, Sulem, P, Thorsteinsdottir, U, Rotter, J I, Chuang, L M, Damrauer, S, Birtwell, D, Brummett, C M, Khera, A V, Natarajan, P, Orho-Melander, M, Flannick, J, Lotta, L A, Willer, C J, Holmen, O L, Ritchie, M D, Ledbetter, D H, Murphy, A J, Borecki, I B, Reid, J G, Overton, J D, Hansson, O, Groop, L, Shah, S H, Kraus, W E, Rader, D J, Chen, Y D I, Hveem, K, Wareham, N J, Kathiresan, S, Melander, O, Stefansson, K, Nordestgaard, B G, Tybjærg-Hansen, A, Abecasis, G R, Altshuler, D, Florez, J C, Boehnke, M, McCarthy, M I, Yancopoulos, G D, Carey, D J, Shuldiner, A R, Baras, A, Dewey, F E & Gromada, J 2018, ' Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes ', Nature Communications, vol. 9, no. 1, 2252 . https://doi.org/10.1038/s41467-018-04611-z
Nature Communications
Nature communications, vol 9, iss 1
Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. We hypothesize that loss of ANGPTL4 function might improve glucose homeostasis and d