Design and Synthesis of Pyrrolidine-5,5-trans-lactams (5-Oxo-hexahydro-pyrrolo[3,2-b]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 1. The α-Methyl-trans-lactam Template

Autor: Borthwick, A. D., Angier, S. J., Crame, A. J., Exall, A. M., Haley, T. M., Hart, G. J., Mason, A. M., Pennell, A. M. K., Weingarten, G. G.

Publikováno v: Journal of Medicinal Chemistry; November 16, 2000, Vol. 43 Issue: 23 p4452-4464, 13p

Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 1. The alpha-methyl-trans-lactam template.

Autor: Borthwick AD; Departments of Medicinal Chemistry 2, Molecular Cell Biology, Biomolecular Structure, and Enzyme Pharmacology, Glaxo Wellcome Research and Development, Medicines Research Centre, Stevenage Herts, U.K. adb3028@glaxowellcome.ac.uk, Angier SJ, Crame AJ, Exall AM, Haley TM, Hart GJ, Mason AM, Pennell AM, Weingarten GG

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2000 Nov 16; Vol. 43 (23), pp. 4452-64.

Structure, expression, and protein engineering of the pyruvate dehydrogenase complex of Escherichia coli.

Autor: Guest JR; Department of Microbiology, University of Sheffield, United Kingdom., Angier SJ, Russell GC

Publikováno v: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 1989; Vol. 573, pp. 76-99.