Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Angie Rizzino"'
Publikováno v:
Pharmaceuticals, Vol 17, Iss 3, p 351 (2024)
In 2024, there will be an estimated 1,466,718 cases of prostate cancer (PC) diagnosed globally, of which 299,010 cases are estimated to be from the US. The typical clinical approach for PC involves routine screening, diagnosis, and standard lines of
Externí odkaz:
https://doaj.org/article/610ccefde7c54d58810124475755889e
Autor:
Ethan P. Metz, Erin L. Wuebben, Phillip J. Wilder, Jesse L. Cox, Kaustubh Datta, Donald Coulter, Angie Rizzino
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)
Abstract Background Quiescent tumor cells pose a major clinical challenge due to their ability to resist conventional chemotherapies and to drive tumor recurrence. Understanding the molecular mechanisms that promote quiescence of tumor cells could he
Externí odkaz:
https://doaj.org/article/b53a1360cbb5429d91603e9c267a376e
Publikováno v:
Diagnostics, Vol 12, Iss 1, p 61 (2021)
Medulloblastoma (MB) is the most common malignant central nervous system tumor in pediatric patients. Mainstay of therapy remains surgical resection followed by craniospinal radiation and chemotherapy, although limitations to this therapy are applied
Externí odkaz:
https://doaj.org/article/3ec96b7b7b6249c39fa042280d286209
Autor:
Staci L. Haney, G. Michael Upchurch, Jana Opavska, David Klinkebiel, Ryan A. Hlady, Abhinav Suresh, Samuel J. Pirruccello, Vipul Shukla, Runqing Lu, Stefan Costinean, Angie Rizzino, Adam R. Karpf, Shantaram Joshi, Patrick Swanson, Rene Opavsky
Publikováno v:
Cell Reports, Vol 15, Iss 6, Pp 1190-1201 (2016)
DNA methyltransferase 3a (DNMT3A) catalyzes the formation of 5-methyl-cytosine in mammalian genomic DNA, and it is frequently mutated in human hematologic malignancies. Bi-allelic loss of Dnmt3a in mice results in leukemia and lymphoma, including chr
Externí odkaz:
https://doaj.org/article/81cec469daba481b8789478486a1ac8e
Autor:
Jesse L Cox, Phillip J Wilder, Joshua M Gilmore, Erin L Wuebben, Michael P Washburn, Angie Rizzino
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62857 (2013)
Medulloblastomas and glioblastomas, the most common primary brain tumors in children and adults, respectively, are extremely difficult to treat. Efforts to identify novel proteins essential for the growth of these tumors may help to further our under
Externí odkaz:
https://doaj.org/article/6da7a91251a74f32a76a175fcba343c5
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76345 (2013)
The self-renewal and pluripotency of embryonic stem cells (ESC) is regulated by a highly integrated network of essential transcription factors, which includes Sox2. Previous studies have shown that elevating Sox2 on its own in mouse ESC induces diffe
Externí odkaz:
https://doaj.org/article/c5e3728f5cda4c7481919ebfe05e15cd
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e44087 (2012)
Medulloblastomas and glioblastomas are devastating tumors that respond poorly to treatment. These tumors have been shown to express SOX2 and overexpression of SOX2 has been correlated with poor prognosis. Although knockdown of SOX2 impairs the growth
Externí odkaz:
https://doaj.org/article/b9e4b85ffdd8491f9c9c57cfaf95c246
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34827 (2012)
Recent studies have shown that the RNA binding protein Musashi 2 (Msi2) plays important roles during development. Msi2 has also been shown to be elevated in several leukemias and its elevated expression has been linked with poorer prognosis in these
Externí odkaz:
https://doaj.org/article/7579e2ea946c4465838ce2e7f30cef43
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15486 (2010)
Master regulators, such as Sox2, Oct4 and Nanog, control complex gene networks necessary for the self-renewal and pluripotency of embryonic stem cells (ESC). These master regulators associate with co-activators and co-repressors to precisely control
Externí odkaz:
https://doaj.org/article/d916b70845e34b09b85fbbb41d7bb3b6
Autor:
Kyle A. Rohrer, Heyu Song, Anum Akbar, Yingling Chen, Suravi Pramanik, Phillip J. Wilder, Erin M. McIntyre, Nagendra K. Chaturvedi, Kishor K. Bhakat, Angie Rizzino, Don W. Coulter, Sutapa Ray
Publikováno v:
Cancers; Volume 15; Issue 8; Pages: 2239
MB is a common childhood malignancy of the central nervous system, with significant morbidity and mortality. Among the four molecular subgroups, MYC-amplified Group 3 MB is the most aggressive type and has the worst prognosis due to therapy resistanc