Enhancing Trial Delivery in Parkinson's Disease: Qualitative Insights from PD STAT

Autor: Angie A. Kehagia, Tracie K. North, Jane Grose, Alison N. Jeffery, Laura Cocking, Rebecca Chapman, Camille Carroll

Publikováno v: Journal of Parkinson's disease. 12(5)

Background: Recruitment and retention of participants in clinical trials for Parkinson’s disease (PD) is challenging. A qualitative study embedded in the PD STAT multi-centre randomised controlled trial of simvastatin for neuroprotection in PD expl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69bcd10578a613ff75f57f11c9f6e6f5
https://pubmed.ncbi.nlm.nih.gov/35466952

Conflicting emergences. Weak vs. strong emergence for the modelling of brain function

Autor: Federico Turkheimer, Paul Expert, Peter J. Hellyer, Jessica Dafflon, Jakub Vohryzek, Louis-David Lord, Mick Brammer, Robert Leech, Angie A. Kehagia

Publikováno v: Turkheimer, F E, Hellyer, P, Kehagia, A A, Expert, P, Lord, L-D, Vohryzek, J, De Faria Dafflon, J, Brammer, M & Leech, R 2019, ' Conflicting Emergences. Weak vs. strong emergence for the modelling of brain function ', Neuroscience and Biobehavioral Reviews, vol. 99, pp. 3-10 . https://doi.org/10.1016/j.neubiorev.2019.01.023

The concept of "emergence" has become commonplace in the modelling of complex systems, both natural and man-made; a functional property" emerges" from a system when it cannot be readily explained by the properties of the system's sub-units. A bewilde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c8a5cb2bae179a4a31e658813a8fd88
https://doi.org/10.1016/j.neubiorev.2019.01.023

Parsing the Roles of the Frontal Lobes and Basal Ganglia in Task Control Using Multivoxel Pattern Analysis

Autor: Trevor W. Robbins, James B. Rowe, Angie A. Kehagia, Rong Ye, Dan W. Joyce, Orla Doyle

Publikováno v: Kehagia, A, Ye, R, Joyce, D, Doyle, O, Rowe, J B & Robbins, T W 2017, ' Parsing the roles of the frontal lobes and basal ganglia in task control using multivoxel pattern analysis ', Journal of Cognitive Neuroscience, vol. 29, no. 8, pp. 1390-1401 . https://doi.org/10.1162/jocn_a_01130

Cognitive control has traditionally been associated with pFC based on observations of deficits in patients with frontal lesions. However, evidence from patients with Parkinson disease indicates that subcortical regions also contribute to control unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2087770674cb0f37b3a25780a1d595b
https://doi.org/10.1162/jocn_a_01130

From homeostasis to behavior: Balanced activity in an exploration of embodied dynamic environmental-neural interaction

Autor: Robert Leech, Federico Turkheimer, Angie A. Kehagia, Peter J. Hellyer, Claudia Clopath

Publikováno v: PLoS Computational Biology, Vol 13, Iss 8, p e1005721 (2017)
PLoS Computational Biology

In recent years, there have been many computational simulations of spontaneous neural dynamics. Here, we describe a simple model of spontaneous neural dynamics that controls an agent moving in a simple virtual environment. These dynamics generate int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef498463e47af60b9299c1a2e83b9522
https://doaj.org/article/76f971a1c2714b2a88aee618b057c9b3

A neurological perspective on the enhancement debate: Lessons learned from Parkinson's disease

Autor: Angie A. Kehagia

Publikováno v: Journal of psychopharmacology (Oxford, England). 30(10)

Cognitive enhancement is signified by adaptive behavioural change following an intervention that targets the brain. Although much of the discussion and research into cognitive enhancement focuses on the effects of neural interventions in healthy indi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d78fcdff3dfc5184df187e72e4f6d8
https://pubmed.ncbi.nlm.nih.gov/27604630