Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Angharad G. Davis"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Tuberculous meningitis (TBM), the most severe form of tuberculosis, causes death in approximately 25% cases despite antibiotic therapy, and half of survivors are left with neurological disability. Mortality and morbidity are contributed to by a dysre
Externí odkaz:
https://doaj.org/article/dfa5c04e53fc4d41b642d444bfe22383
Autor:
Elsa du Bruyn, Cari Stek, Remi Daroowala, Qonita Said-Hartley, Marvin Hsiao, Georgia Schafer, Rene T. Goliath, Fatima Abrahams, Amanda Jackson, Sean Wasserman, Brian W. Allwood, Angharad G. Davis, Rachel P.-J. Lai, Anna K. Coussens, Katalin A. Wilkinson, Jantina de Vries, Nicki Tiffin, Maddalena Cerrone, Ntobeko A. B. Ntusi, HIATUS consortium, Catherine Riou, Robert J. Wilkinson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Here the authors describe outcomes of SARS-CoV-2 infection in an African setting of high HIV-1 and tuberculosis prevalence. They find that tuberculosis is a common co-morbidity in patients admitted to hospital with COVID-19 and that the immune respon
Externí odkaz:
https://doaj.org/article/d34350d162f94a06b08193aa90938e4d
Autor:
Nathan C Bahr, Fiona V Cresswell, Nguyen Thuy Thuong Thuong, Rachel P.J. Lai, Angharad G. Davis, David R Boulware, Robert J Wilkinson, Johan Schoeman, Marise Bremer, Joseph Donovan, Ronald Van Toorn, Guy E Thwaites, Ariba Dadabhoy
Publikováno v:
Wellcome Open Research, Vol 5 (2021)
A dysregulated host immune response significantly contributes to morbidity and mortality in tuberculous meningitis (TBM). Effective host directed therapies (HDTs) are critical to improve survival and clinical outcomes. Currently only one HDT, dexamet
Externí odkaz:
https://doaj.org/article/1082f9028b78463baff862754b13c9a1
Autor:
Angharad G. Davis, Sean Wasserman, Mpumi Maxebengula, Cari Stek, Marise Bremer, Remy Daroowala, Saalikha Aziz, Rene Goliath, Stephani Stegmann, Sonya Koekemoer, Amanda Jackson, Louise Lai Sai, Yakub Kadernani, Thandi Sihoyiya, C.Jason Liang, Lori Dodd, Paolo Denti, Thomas Crede, Jonathan Naude, Patryk Szymanski, Yakoob Vallie, Ismail Banderker, Shiraz Moosa, Peter Raubenheimer, Rachel P.J. Lai, John Joska, Sam Nightingale, Anna Dreyer, Gerda Wahl, Curtis Offiah, Isak Vorster, Sally Candy, Frances Robertson, Ernesta Meintjes, Gary Maartens, John Black, Graeme Meintjes, Robert J. Wilkinson
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: Tuberculous meningitis (TBM) is the most lethal form of tuberculosis with a mortality of ~50% in those co-infected with HIV-1. Current antibiotic regimens are based on those known to be effective in pulmonary TB and do not account for the
Externí odkaz:
https://doaj.org/article/792fe077a27941ba962dcfc399553a70
Autor:
Fiona V Cresswell, Angharad G. Davis, Kusum Sharma, Robindra Basu Roy, Ahmad Rizal Ganiem, Enock Kagimu, Regan Solomons, Robert J. Wilkinson, Nathan C Bahr, Nguyen Thuy Thuong Thuong, Tuberculous Meningitis International Research Consortium
Publikováno v:
Wellcome Open Research, Vol 4 (2021)
The pathogenesis of Tuberculous meningitis (TBM) is poorly understood, but contemporary molecular biology technologies have allowed for recent improvements in our understanding of TBM. For instance, neutrophils appear to play a significant role in th
Externí odkaz:
https://doaj.org/article/04e368a4097b43cda1a7ffab7f4734cf
Autor:
Fiona V Cresswell, Angharad G. Davis, Kusum Sharma, Robindra Basu Roy, Ahmad Rizal Ganiem, Enock Kagimu, Regan Solomons, Robert J. Wilkinson, Nathan C Bahr, Nguyen Thuy Thuong Thuong, Tuberculous Meningitis International Research Consortium
Publikováno v:
Wellcome Open Research, Vol 4 (2020)
The pathogenesis of Tuberculous meningitis (TBM) is poorly understood, but contemporary molecular biology technologies have allowed for recent improvements in our understanding of TBM. For instance, neutrophils appear to play a significant role in th
Externí odkaz:
https://doaj.org/article/de26b023cf4b487f8abf8714ffd9863b
Autor:
Angharad G. Davis, Sam Nightingale, Priscilla E. Springer, Regan Solomons, Ana Arenivas, Robert J. Wilkinson, Suzanne T. Anderson, Felicia C. Chow, Tuberculous Meningitis International Research Consortium
Publikováno v:
Wellcome Open Research, Vol 4 (2019)
In those who survive tuberculous meningitis (TBM), the long-term outcome is uncertain; individuals may suffer neurocognitive, functional and psychiatric impairment, which may significantly affect their ability to lead their lives as they did prior to
Externí odkaz:
https://doaj.org/article/fe510c7842cf4fc48788fca64ab29c9c
Autor:
Angharad G Davis, Anna J Dreyer, Christine Albertyn, Mpumi Maxebengula, Cari Stek, Sean Wasserman, Suzaan Marais, Kathleen Bateman, Mark Solms, John Joska, Robert J Wilkinson, Sam Nightingale
BackgroundCognitive impairment is reported as a common complication in adult tuberculous meningitis (TBM), yet few studies have systematically assessed the frequency and nature of impairment. Moreover, the impact of impairment on functioning and medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27c46aa44137f4edf59964552f38f7a
Autor:
Angharad G Davis, Sean Wasserman, Cari Stek, Mpumi Maxebengula, C Jason Liang, Stephani Stegmann, Sonya Koekemoer, Amanda Jackson, Yakub Kadernani, Marise Bremer, Remy Daroowala, Saalikha Aziz, Rene Goliath, Louise Lai Sai, Thandi Sihoyiya, Paolo Denti, Rachel P J Lai, Thomas Crede, Jonathan Naude, Patryk Szymanski, Yakoob Vallie, Ismail Abbas Banderker, Muhammed S Moosa, Peter Raubenheimer, Sally Candy, Curtis Offiah, Gerda Wahl, Isak Vorster, Gary Maartens, John Black, Graeme Meintjes, Robert J Wilkinson
Background Drug regimens that include intensified antibiotics alongside effective anti-inflammatory therapies may improve outcomes in tuberculous meningitis (TBM). Safety data on their use in combination and in the context of human immunodeficiency v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c42911404e9e173481f72774be3e0f3f
Autor:
Angharad G Davis, Sean Wasserman, Cari Stek, Mpumi Maxebengula, C. Jason Liang, Stephani Stegmann, Sonya Koekemoer, Amanda Jackson, Yakub Kadernani, Marise Bremer, Remy Daroowala, Saalikha Aziz, Rene Goliath, Louise Lai Sai, Thandi Sihoyiya, Paolo Denti, Rachel PJ Lai, Thomas Crede, Jonathan Naude, Patryk Szymanski, Yakoob Vallie, Ismail Abbas Banderker, Muhammed S Moosa, Peter Raubenheimer, Sally Candy, Curtis Offiah, Gerda Wahl, Isak Vorster, Gary Maartens, John Black, Graeme Meintjes, Robert J Wilkinson
Publikováno v:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
BackgroundDrug regimens which include intensified antibiotics alongside effective anti-inflammatory therapies may improve outcomes in Tuberculous Meningitis (TBM). Safety data on their use in combination and in the context of HIV is needed to inform