Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Angharad, Lloyd"'
Autor:
Terri V. Cornforth, Nathifa Moyo, Suzanne Cole, Emily P. S. Lam, Tatiana Lobry, Ron Wolchinsky, Angharad Lloyd, Katarzyna Ward, Eleanor M. Denham, Giulia Masi, Phyllis Tea Qing Yun, Colin Moore, Selsabil Dhaouadi, Gurdyal S. Besra, Natacha Veerapen, Patricia T. Illing, Julian P. Vivian, Jeremy M. Raynes, Jérôme Le Nours, Anthony W. Purcell, Samit Kundu, Jonathan D. Silk, Luke Williams, Sophie Papa, Jamie Rossjohn, Duncan Howie, Joseph Dukes
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundMajor histocompatibility complex class-1-related protein (MR1), unlike human leukocyte antigen (HLA) class-1, was until recently considered to be monomorphic. MR1 presents metabolites in the context of host responses to bacterial infection.
Externí odkaz:
https://doaj.org/article/8f539e9eaf5e40e19fbc3e2c06f07574
Autor:
Sophie Papa, Luke Williams, Joseph Dukes, Jamie Rossjohn, Jonathan D Silk, Suzanne Cole, Emily Lam, Samit Kundu, Katarzyna Ward, Duncan Howie, Terri V Cornforth, Nathifa Moyo, Tatiana Lobry, Ron Wolchinsky, Angharad Lloyd, Eleanor M Denham, Gurdyal S Besra, Patricia Illing, Bruce MacLachlan, Julian Vivian, Jeremy Raynes, Jerome Le Nours, Anthony Purcell
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/d7d61dd8f23b40c19240771e3414c4c9
Autor:
Alexander Greenshields-Watson, Meriem Attaf, Bruce J. MacLachlan, Thomas Whalley, Cristina Rius, Aaron Wall, Angharad Lloyd, Hywel Hughes, Kathryn E. Strange, Georgina H. Mason, Andrea J. Schauenburg, Sarah L. Hulin-Curtis, James Geary, Yuan Chen, Sarah N. Lauder, Kathryn Smart, Dhanasekaran Vijaykrishna, Miguel L. Grau, Mikhail Shugay, Robert Andrews, Garry Dolton, Pierre J. Rizkallah, Awen M. Gallimore, Andrew K. Sewell, Andrew J. Godkin, David K. Cole
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107885- (2020)
Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by usi
Externí odkaz:
https://doaj.org/article/ac1881b0cc804226bb104e9cab830657
Autor:
Sarah A. E. Galloway, Garry Dolton, Meriem Attaf, Aaron Wall, Anna Fuller, Cristina Rius, Valentina Bianchi, Sarah Theaker, Angharad Lloyd, Marine E. Caillaud, Inge Marie Svane, Marco Donia, David K. Cole, Barbara Szomolay, Pierre Rizkallah, Andrew K. Sewell
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Recent immunotherapeutic approaches using adoptive cell therapy, or checkpoint blockade, have demonstrated the powerful anti-cancer potential of CD8 cytotoxic T-lymphocytes (CTL). While these approaches have shown great promise, they are only effecti
Externí odkaz:
https://doaj.org/article/eafad320a3c049e2a23c4b349b6aa310
Autor:
Anna Fuller, Aaron Wall, Michael Crowther, Angharad Lloyd, Alexei Zhurov, Andrew Sewell, David Cole, Konrad Beck
Publikováno v:
Bio-Protocol, Vol 7, Iss 13 (2017)
T cell receptor (TCR) recognition of foreign peptide fragments, presented by peptide major histocompatibility complex (pMHC), governs T-cell mediated protection against pathogens and cancer. Many factors govern T-cell sensitivity, including the affin
Externí odkaz:
https://doaj.org/article/b01516c2829241cca16624082211f55d
Autor:
Conor Hayes, Marine C.C. Raman, C.H. Coles, Stephen Harper, Linda Hibbert, Patrick J. Lupardus, David K. Cole, Angharad Lloyd, Catriona McMurran, Miriam Hock
Publikováno v:
The Journal of Biological Chemistry
T cell-mediated immunity is governed primarily by T cell receptor (TCR) recognition of peptide-human leukocyte antigen (pHLA) complexes and is essential for immunosurveillance and disease control. This interaction is generally stabilized by interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c26e82c5e591b3537bb07af2f9c07f8
https://doi.org/10.1074/jbc.ra120.014016
https://doi.org/10.1074/jbc.ra120.014016
Autor:
R. Martinez Hague, Fiona Chester, Jane Harper, S. Griffin, Angharad Lloyd, Emma Baston, R. Mulvaney, Annelise Vuidepot, K. Smith, S. Harper, K. Wiederhold, A.R. Stacey, Andrew Alexander Knox, S. Malla, K.L. Lowe, C.H. Coles, Z. Donnellan, Samantha Paston, Joseph Dukes, Bent K. Jakobsen, R.A. Robinson, M. Aleksic, A. Walker, Michelle L. McCully
Publikováno v:
The Journal of Immunology. 204:1943-1953
The molecular rules driving TCR cross-reactivity are poorly understood and, consequently, it is unclear the extent to which TCRs targeting the same Ag recognize the same off-target peptides. We determined TCR–peptide–HLA crystal structures and, u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b03e627be240f30ea60a4a4dabb09d
https://doi.org/10.4049/jimmunol.1900915
https://doi.org/10.4049/jimmunol.1900915
Autor:
Robert Andrews, Sarah Nicol Lauder, Aaron Wall, Kathryn Smart, Bruce J. MacLachlan, Meriem Attaf, Pierre J. Rizkallah, Dhanasekaran Vijaykrishna, Yuan Chen, Georgina H. Mason, Andrew James Godkin, Garry Dolton, Mikhail Shugay, David K. Cole, Angharad Lloyd, Cristina Rius, Andrew K. Sewell, Miguel L. Grau, Andrea J. A. Schauenburg, Alexander Greenshields-Watson, Hywel Hughes, Kathryn E. Strange, Awen Gallimore, James Geary, Sarah Hulin-Curtis, Thomas Whalley
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107885-(2020)
Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75db8e6035331d3fe6e4c0c6bffbf5e9
Autor:
Malkit Sami, Ben de Wet, Elizabeth A. Potter, Rory M. Crean, Katy A. Lloyd, Velupillai Srikannathasan, Nikolai Lissin, Milos Aleksic, Anitha Jeyanthan, Miriam Hock, David K. Cole, Peter Eamon Molloy, Pierre J. Rizkallah, Marco Lepore, Annelise Vuidepot, Christopher J. Holland, Brian Cameron, Thomas Blicher, Robert J. Pengelly, Christopher R. Pudney, Ross A. Robinson, Johanne M. Pentier, Thomas E. Spinner, Marc W. van der Kamp, Bent K. Jakobsen, Nathaniel Liddy, Paul J. Conroy, Stephen Harper, Angharad Lloyd
Publikováno v:
J Clin Invest
Tumor-associated peptide-human leukocyte antigen complexes (pHLAs) represent the largest pool of cell surface-expressed cancer-specific epitopes, making them attractive targets for cancer therapies. Soluble bispecific molecules that incorporate an an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbe9e3e9f83c5de1920113bed8d5316
https://europepmc.org/articles/PMC7190993/
https://europepmc.org/articles/PMC7190993/
Autor:
Alexander, Greenshields-Watson, Meriem, Attaf, Bruce J, MacLachlan, Thomas, Whalley, Cristina, Rius, Aaron, Wall, Angharad, Lloyd, Hywel, Hughes, Kathryn E, Strange, Georgina H, Mason, Andrea J, Schauenburg, Sarah L, Hulin-Curtis, James, Geary, Yuan, Chen, Sarah N, Lauder, Kathryn, Smart, Dhanasekaran, Vijaykrishna, Miguel L, Grau, Mikhail, Shugay, Robert, Andrews, Garry, Dolton, Pierre J, Rizkallah, Awen M, Gallimore, Andrew K, Sewell, Andrew J, Godkin, David K, Cole
Publikováno v:
Cell Reports
Summary T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb3a31384ca81261b808e1aa2395f38d
https://pubmed.ncbi.nlm.nih.gov/32668259
https://pubmed.ncbi.nlm.nih.gov/32668259