E proteins sharpen neurogenesis by modulating proneural bHLH transcription factors’ activity in an E-box-dependent manner

Autor: Gwenvael Le Dréau, René Escalona, Raquel Fueyo, Antonio Herrera, Juan D Martínez, Susana Usieto, Anghara Menendez, Sebastian Pons, Marian A Martinez-Balbas, Elisa Marti

Publikováno v: eLife, Vol 7 (2018)

Class II HLH proteins heterodimerize with class I HLH/E proteins to regulate transcription. Here, we show that E proteins sharpen neurogenesis by adjusting the neurogenic strength of the distinct proneural proteins. We find that inhibiting BMP signal

Externí odkaz: https://doaj.org/article/e8d4c42983b54f56a8fb66102ed7003a

Dbnl and ß-catenin promote pro-N-cadherin processing to maintain apico-basal polarity

Autor: Antonio Herrera, Andrea Ochoa, Blanca Torroba, Anghara Menendez, Sebastian Pons

Publikováno v: Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
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The Journal of Cell Biology

© 2021 Herrera et al.
The neural tube forms when neural stem cells arrange into a pseudostratified, single-cell–layered epithelium, with a marked apico-basal polarity, and in which adherens junctions (AJs) concentrate in the subapical domain.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7f4e08b759b3e820b9f326089f2059
http://hdl.handle.net/10261/241513

E proteins sharpen neurogenesis by modulating proneural bHLH transcription factors’ activity in an E-box-dependent manner

Autor: Marian A. Martínez-Balbás, Anghara Menendez, René Escalona, Elisa Martí, Raquel Fueyo, Juan Daniel Martínez, Antonio Herrera, Gwenvael Le Dréau, Sebastian Pons, Susana Usieto

Publikováno v: eLife, Vol 7 (2018)
eLife
Digital.CSIC. Repositorio Institucional del CSIC
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Class II HLH proteins heterodimerize with class I HLH/E proteins to regulate transcription. Here, we show that E proteins sharpen neurogenesis by adjusting the neurogenic strength of the distinct proneural proteins. We find that inhibiting BMP signal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83df5680ed52a23e04bd401d5f820e7
https://elifesciences.org/articles/37267

E proteins differentially co-operate with proneural bHLH transcription factors to sharpen neurogenesis

Autor: Antonio Herrera, Gwenvael Le Dréau, Sebastian Pons, René Escalona, Marian A. Martínez-Balbás, Susana Usieto, Juan Daniel Martínez, Elisa Martí, Raquel Fueyo, Anghara Menendez

Basic HLH proteins heterodimerize with class I HLH/E proteins to promote transcription. Here we show that E proteins differentially co-operate with proneural bHLH transcription factors sharpening their neurogeneic activity. We find that inhibiting BM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2721342fb3cacc908e41937b610a77c5

Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation

Autor: Anghara Menendez, Milica Stefanovic, Joan Caballería, Pau Sancho-Bru, Albert Morales, Montserrat Marí, José C. Fernández-Checa, Leonel Joannas, Carla V. Rothlin, Carmen García-Ruiz, Cristina Bárcena, Pablo García de Frutos, Anna Tutusaus

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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© 2015 European Association for the Study of the Liver. Background & Aims Liver fibrosis, an important health concern associated to chronic liver injury that provides a permissive environment for cancer development, is characterized by accumulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59888e8748358db7721904cf988a231