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Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD.

Autor: Hristova VA; Dynamic Omics, Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.; These authors contributed equally., Watson A; Faculty of Medicine, University of Southampton, Southampton, UK.; School of Clinical Medicine, University of Cambridge, Cambridge, UK.; These authors contributed equally., Chaerkady R; Dynamic Omics, Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Glover MS; Dynamic Omics, Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Ackland J; Faculty of Medicine, University of Southampton, Southampton, UK., Angerman B; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Belfield G; Translational Genomics, Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Belvisi MG; Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.; NHLI, Imperial College, London, UK., Burke H; Faculty of Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University Hospital, Southampton, UK., Cellura D; Faculty of Medicine, University of Southampton, Southampton, UK., Clark HW; Neonatology, Faculty of Population Health Sciences, EGA Institute for Women's Health, University College London, London, UK.; NIHR University College London Hospital Biomedical Research, University College London Hospital, London, UK., Etal D; Translational Genomics, Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Freeman A; Faculty of Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University Hospital, Southampton, UK., Heinson AI; Faculty of Medicine, University of Southampton, Southampton, UK., Hess S; Dynamic Omics, Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Hühn M; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Hall E; Faculty of Medicine, University of Southampton, Southampton, UK., Mackay A; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.; NHLI, Imperial College, London, UK., Madsen J; Faculty of Medicine, University of Southampton, Southampton, UK., McCrae C; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA., Muthas D; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Novick S; Data Sciences and Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Ostridge K; Faculty of Medicine, University of Southampton, Southampton, UK.; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Öberg L; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Platt A; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Postle AD; Faculty of Medicine, University of Southampton, Southampton, UK., Spalluto CM; Faculty of Medicine, University of Southampton, Southampton, UK., Vaarala O; Faculty of Medicine, University of Helsinki, Helsinki, Finland., Wang J; Dynamic Omics, Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Staples KJ; Faculty of Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University Hospital, Southampton, UK., Wilkinson TMA; Faculty of Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University Hospital, Southampton, UK.

Publikováno v: ERJ open research [ERJ Open Res] 2022 May 15; Vol. 9 (3). Date of Electronic Publication: 2022 May 15 (Print Publication: 2023).