Výsledky vyhledávání - "Angelyn V. Nguyen"

Differential Contributions of Actin and Myosin to the Physical Phenotypes and Invasion of Pancreatic Cancer Cells

Autor: Kenneth H. Hu, Amy C. Rowat, Pei-Yu Chiou, Brittany Trompetto, Eric J. Deeds, Angelyn V. Nguyen, Xing Haw Marvin Tan, Manish J. Butte, Michael Scott

Publikováno v: Cell Mol Bioeng
Cellular and molecular bioengineering, vol 13, iss 1

INTRODUCTION: Metastasis is a fundamentally physical process in which cells deform through narrow gaps and generate forces to invade surrounding tissues. While it is commonly thought that increased cell deformability is an advantage for invading cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec6bed2caaefc80495badb70d22f43b
https://doi.org/10.1007/s12195-019-00603-1

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Stiffness of pancreatic cancer cells is associated with increased invasive potential

Autor: Sophia Hohlbauch, Ewan A. Gibb, Andrew Nguyen, Nicholas A. Geisse, Alia M. Welsh, A. Gordon Robertson, Timothy R. Donahue, Nanping Wu, Michael Scott, Angelyn V. Nguyen, Amy C. Rowat, Kendra D. Nyberg

Publikováno v: Integrative biology : quantitative biosciences from nano to macro, vol 8, iss 12

Metastasis is a fundamentally physical process in which cells are required to deform through narrow gaps as they invade surrounding tissues and transit to distant sites. In many cancers, more invasive cells are more deformable than less invasive cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f8f20d82483d186c625cb8c85d0a06
https://doi.org/10.1039/c6ib00135a

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Predicting cancer cell invasion by single-cell physical phenotyping

Autor: Kendra D. Nyberg, Samuel L. Bruce, Tae-Hyung Kim, Navjot Kaur Gill, Erica K. Sloan, Amy C. Rowat, Angelyn V. Nguyen, Clara K. Chan

Publikováno v: Integrative biology : quantitative biosciences from nano to macro. 10(4)

The physical properties of cells are promising biomarkers for cancer diagnosis and prognosis. Here we determine the physical phenotypes that best distinguish human cancer cell lines, and their relationship to cell invasion. We use the high throughput

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b2eb1c54ba51f1be0ff29c207ce807
https://pubmed.ncbi.nlm.nih.gov/29589844

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Cancer cells become less deformable and more invasive with activation of β-adrenergic signaling

Autor: Kendra D. Nyberg, Tae-Hyung Kim, Nicholas A. Geisse, Sophia Hohlbauch, Cameron J. Nowell, Navjot Kaur Gill, Erica K. Sloan, Angelyn V. Nguyen, Amy C. Rowat

Publikováno v: Journal of cell science. 129(24)

Invasion by cancer cells is a critical step in metastasis. An oversimplified view in the literature is that cancer cells become more deformable as they become more invasive. β-adrenergic receptor (βAR) signaling drives invasion and metastasis, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd0c989fccb5abfdd46c4aa5f0d909d5
https://pubmed.ncbi.nlm.nih.gov/27875276

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Structural and computational studies of the Staphylococcus aureus sortase B-substrate complex reveal a substrate-stabilized oxyanion hole

Autor: Brendan R. Amer, Michael E. Jung, Robert T. Clubb, Sung Wook Yi, Grace L. Huang, Michael R. Sawaya, Alex W. Jacobitz, Angelyn V. Nguyen, Jeff Wereszczynski, J. Andrew McCammon

Publikováno v: Jacobitz, AW; Wereszczynski, J; Yi, SW; Amer, BR; Huang, GL; Nguyen, AV; et al.(2014). Structural and computational studies of the Staphylococcus aureus sortase B-substrate complex reveal a substrate-stabilized oxyanion hole. Journal of Biological Chemistry, 289(13), 8891-8902. doi: 10.1074/jbc.M113.509273. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2928d1bp
The Journal of biological chemistry, vol 289, iss 13

Sortase cysteine transpeptidases covalently attach proteins to the bacterial cell wall or assemble fiber-like pili that promote bacterial adhesion. Members of this enzyme superfamily are widely distributed in Gram-positive bacteria that frequently ut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f639b8657cd310f75deeb8965d79773
http://www.escholarship.org/uc/item/2928d1bp

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The aminoglycoside antibiotic kanamycin damages DNA bases in Escherichia coli: caffeine potentiates the DNA-damaging effects of kanamycin while suppressing cell killing by ciprofloxacin in Escherichia coli and Bacillus anthracis

Autor: Jessica Yuan, Hanjing Yang, Tina Manzhu Kang, Elinne Becket, Jeffrey H Miller, Angelyn V. Nguyen

Publikováno v: Antimicrobial agents and chemotherapy. 56(6)

The distribution of mutants in the Keio collection of Escherichia coli gene knockout mutants that display increased sensitivity to the aminoglycosides kanamycin and neomycin indicates that damaged bases resulting from antibiotic action can lead to ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249644cb74f89b433b7e91bfd1124be5
https://pubmed.ncbi.nlm.nih.gov/22391551

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Structural and Computational Studies of the Staphylococcus Aureus Sortase B-Substrate Complex Provide New Insight into the Mechanism of Sortase Transpeptidases

Autor: Brendan R. Amer, J. Andrew McCammon, Michael E. Jung, Robert T. Clubb, Sung Wook Yi, Grace L. Huang, Alex W. Jacobitz, Angelyn V. Nguyen, Jeff Wereszczynski, Michael R. Sawaya

Publikováno v: Biophysical Journal. 106:677a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c422215b7fccae49aa39e341ee0874
https://doi.org/10.1016/j.bpj.2013.11.3749

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