Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy.

Autor: Angelopoulou, Andriani¹ (AUTHOR), Theocharous, Giorgos¹ (AUTHOR), Valakos, Dimitrios² (AUTHOR), Polyzou, Aikaterini¹ (AUTHOR), Magkouta, Sophia^1,3,4 (AUTHOR), Myrianthopoulos, Vassilios⁵ (AUTHOR), Havaki, Sophia¹ (AUTHOR), Fiorillo, Marco⁶ (AUTHOR), Tremi, Ioanna¹ (AUTHOR), Vachlas, Konstantinos⁷ (AUTHOR), Nisotakis, Theodoros¹ (AUTHOR), Thanos, Dimitris-Foivos¹ (AUTHOR), Pantazaki, Anastasia⁸ (AUTHOR), Kletsas, Dimitris⁹ (AUTHOR), Bartek, Jiri^10,11 (AUTHOR), Petty, Russell⁴ (AUTHOR), Thanos, Dimitris² (AUTHOR), McCrimmon, Rory J⁴ (AUTHOR), Papaspyropoulos, Angelos¹ (AUTHOR) a.papaspyropoulos@med.uoa.gr, Gorgoulis, Vassilis G^1,2,4,12,13 (AUTHOR) vgorg@med.uoa.gr

Publikováno v: Molecular Cancer. 7/25/2024, Vol. 23 Issue 1, p1-13. 13p.

Interplay of Developmental Hippo–Notch Signaling Pathways with the DNA Damage Response in Prostate Cancer.

Autor: Mourkioti, Ioanna¹ (AUTHOR), Angelopoulou, Andriani¹ (AUTHOR), Belogiannis, Konstantinos¹ (AUTHOR), Lagopati, Nefeli^1,2 (AUTHOR), Potamianos, Spyridon³ (AUTHOR), Kyrodimos, Efthymios³ (AUTHOR), Gorgoulis, Vassilis^1,2,4,5,6,7 (AUTHOR) vgorg@med.uoa.gr, Papaspyropoulos, Angelos^1,2 (AUTHOR) vgorg@med.uoa.gr

Publikováno v: Cells (2073-4409). Aug2022, Vol. 11 Issue 15, p2449-2449. 20p.

RASSF1A disrupts the NOTCH signaling axis via SNURF/RNF4-mediated ubiquitination of HES1

Autor: Papaspyropoulos, Angelos Angelopoulou, Andriani Mourkioti, Ioanna Polyzou, Aikaterini Pankova, Daniela Toskas, Konstantinos Lanfredini, Simone Pantazaki, Anastasia A. and Lagopati, Nefeli Kotsinas, Athanassios Evangelou, Konstantinos and Chronopoulos, Efstathios O'Neill, Eric Gorgoulis, Vassilis

RASSF1A promoter methylation has been correlated with tumor dedifferentiation and aggressive oncogenic behavior. Nevertheless, the underlying mechanism of RASSF1A-dependent tumor dedifferentiation remains elusive. Here, we show that RASSF1A directly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::24e7a6e821caa243bc723d66705666ab
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3033441

A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization

Autor: Zampetidis, Christos P. Galanos, Panagiotis Angelopoulou, Andriani Zhu, Yajie Polyzou, Aikaterini Karamitros, Timokratis Kotsinas, Athanassios Lagopati, Nefeli Mourkioti, Ioanna Mirzazadeh, Reza Polyzos, Alexandros Garnerone, Silvano Mizi, Athanasia Gusmao, Eduardo G. Sofiadis, Konstantinos Gal, Zita Larsen, Dorthe H. Pefani, Dafni-Eleftheria Demaria, Marco Tsirigos, Aristotelis and Crosetto, Nicola Maya-Mendoza, Apolinar Papaspyropoulos, Angelos and Evangelou, Konstantinos Bartek, Jiri Papantonis, Argyris and Gorgoulis, Vassilis G.

Oncogene-induced senescence (OIS) is an inherent and important tumor suppressor mechanism. However, if not removed timely via immune surveillance, senescent cells also have detrimental effects. Although this has mostly been attributed to the senescen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::02ee6e0502f0a8cf1c9b18cb18fe866e
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3033307

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