Palmitate-induced cardiac lipotoxicity is relieved by Quercetin and its novel acetylated derivative Q2 through inhibition of oxidative stress and inflammation.

Autor: Granieri MC; Laboratory of Cellular and Molecular Cardiovascular Pathophysiology, Department of Biology, E., and E. S. (DiBEST), University of Calabria, 87036 Rende, Italy., Rocca C; Laboratory of Cellular and Molecular Cardiovascular Pathophysiology, Department of Biology, E., and E. S. (DiBEST), University of Calabria, 87036 Rende, Italy., De Bartolo A; Laboratory of Cellular and Molecular Cardiovascular Pathophysiology, Department of Biology, E., and E. S. (DiBEST), University of Calabria, 87036 Rende, Italy., Nettore IC; Department of Clinical Medicine and Surgery, School of Medicine, University of Naples Federico II, 80131 Naples, Italy., Rago V; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy., Romeo N; Laboratory of Cellular and Molecular Cardiovascular Pathophysiology, Department of Biology, E., and E. S. (DiBEST), University of Calabria, 87036 Rende, Italy., Ceramella J; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy., Mariconda A; Department of Science, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy., Macchia PE; Department of Clinical Medicine and Surgery, School of Medicine, University of Naples Federico II, 80131 Naples, Italy., Ungaro P; Institute for Endocrinology and Experimental Oncology (IEOS) 'Gaetano Salvatore', National Research Council, 80131 Naples, Italy., Sinicropi MS; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy., Angelone T; Laboratory of Cellular and Molecular Cardiovascular Pathophysiology, Department of Biology, E., and E. S. (DiBEST), University of Calabria, 87036 Rende, Italy; National Institute of Cardiovascular Research (INRC), 40126 Bologna, Italy.

Publikováno v: Vascular pharmacology [Vascul Pharmacol] 2024 Jun; Vol. 155, pp. 107323.

The redox-active defensive Selenoprotein T as a novel stress sensor protein playing a key role in the pathophysiology of heart failure.

Autor: De Bartolo A; Cellular and Molecular Cardiovascular Pathophysiology Laboratory, Department of Biology, E. and E. S. (DiBEST), University of Calabria, Arcavacata di Rende, 87036, Cosenza, Italy., Pasqua T; Department of Health Science, University Magna Graecia of Catanzaro, 88100, Catanzaro, Italy., Romeo N; Cellular and Molecular Cardiovascular Pathophysiology Laboratory, Department of Biology, E. and E. S. (DiBEST), University of Calabria, Arcavacata di Rende, 87036, Cosenza, Italy., Rago V; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy., Perrotta I; Centre for Microscopy and Microanalysis (CM2), Department of Biology, E. and E. S. (DiBEST), University of Calabria, 87036, Rende, Italy., Giordano F; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy., Granieri MC; Cellular and Molecular Cardiovascular Pathophysiology Laboratory, Department of Biology, E. and E. S. (DiBEST), University of Calabria, Arcavacata di Rende, 87036, Cosenza, Italy., Marrone A; Cellular and Molecular Cardiovascular Pathophysiology Laboratory, Department of Biology, E. and E. S. (DiBEST), University of Calabria, Arcavacata di Rende, 87036, Cosenza, Italy., Mazza R; Organ and System Physiology Laboratory, Department of Biology, E. and E. S. (DiBEST), University of Calabria, Arcavacata di Rende, 87036, Cosenza, Italy., Cerra MC; Organ and System Physiology Laboratory, Department of Biology, E. and E. S. (DiBEST), University of Calabria, Arcavacata di Rende, 87036, Cosenza, Italy., Lefranc B; UNIROUEN, Inserm U1239, Neuroendocrine, Endocrine and Germinal Differentiation and Communication (NorDiC), Rouen Normandie University, 76000, Mont-Saint-Aignan, France.; UNIROUEN, UMS-UAR HERACLES, PRIMACEN, Cell Imaging Platform of Normandy, Institute for Research and Innovation in Biomedicine (IRIB), 76183, Rouen, France., Leprince J; UNIROUEN, Inserm U1239, Neuroendocrine, Endocrine and Germinal Differentiation and Communication (NorDiC), Rouen Normandie University, 76000, Mont-Saint-Aignan, France.; UNIROUEN, UMS-UAR HERACLES, PRIMACEN, Cell Imaging Platform of Normandy, Institute for Research and Innovation in Biomedicine (IRIB), 76183, Rouen, France., Anouar Y; UNIROUEN, Inserm U1239, Neuroendocrine, Endocrine and Germinal Differentiation and Communication (NorDiC), Rouen Normandie University, 76000, Mont-Saint-Aignan, France., Angelone T; Cellular and Molecular Cardiovascular Pathophysiology Laboratory, Department of Biology, E. and E. S. (DiBEST), University of Calabria, Arcavacata di Rende, 87036, Cosenza, Italy. tommaso.angelone@unical.it.; National Institute of Cardiovascular Research (INRC), 40126, Bologna, Italy. tommaso.angelone@unical.it., Rocca C; Cellular and Molecular Cardiovascular Pathophysiology Laboratory, Department of Biology, E. and E. S. (DiBEST), University of Calabria, Arcavacata di Rende, 87036, Cosenza, Italy.; National Institute of Cardiovascular Research (INRC), 40126, Bologna, Italy.

Publikováno v: Journal of translational medicine [J Transl Med] 2024 Apr 20; Vol. 22 (1), pp. 375. Date of Electronic Publication: 2024 Apr 20.

The histone methyltransferase SMYD1 is induced by thermogenic stimuli in adipose tissue.

Autor: Cicatiello AG; Department of Clinical Medicine & Surgery, University of Naples 'Federico II', 80131, Naples, Italy., Nappi A; Department of Clinical Medicine & Surgery, University of Naples 'Federico II', 80131, Naples, Italy., Franchini F; Department of Clinical Medicine & Surgery, University of Naples 'Federico II', 80131, Naples, Italy., Nettore IC; Department of Clinical Medicine & Surgery, University of Naples 'Federico II', 80131, Naples, Italy., Raia M; CEINGE, Biotecnologie Avanzate S.c.a.r.l., 80131, Naples, Italy., Rocca C; Laboratory of Cellular & Molecular Cardiovascular Pathophysiology, Department of Biology, Ecology & Earth Sciences (DiBEST), University of Calabria, Arcavacata di Rende, 87036, Cosenza, Italy., Angelone T; Laboratory of Cellular & Molecular Cardiovascular Pathophysiology, Department of Biology, Ecology & Earth Sciences (DiBEST), University of Calabria, Arcavacata di Rende, 87036, Cosenza, Italy.; National Institute of Cardiovascular Research (I.N.R.C.), 40126, Bologna, Italy., Dentice M; Department of Clinical Medicine & Surgery, University of Naples 'Federico II', 80131, Naples, Italy.; CEINGE, Biotecnologie Avanzate S.c.a.r.l., 80131, Naples, Italy., Ungaro P; National Research Council - Institute for Experimental Endocrinology & Oncology 'Gaetano Salvatore', 80131, Naples, Italy., Macchia PE; Department of Clinical Medicine & Surgery, University of Naples 'Federico II', 80131, Naples, Italy.

Publikováno v: Epigenomics [Epigenomics] 2024 Mar; Vol. 16 (6), pp. 359-374. Date of Electronic Publication: 2024 Mar 05.

Quercetin and its derivative Q2 modulate chromatin dynamics in adipogenesis and Q2 prevents obesity and metabolic disorders in rats

Autor: Nettore IC (1), Rocca C (2), Mancino G (1), Albano L(3, Amelio D (2), Grande F(5), Puoci F(5), Pasqua T(2), Desiderio S(1), Mazza R(2), Terracciano D(3), Colao A(1), Bèguinot F(3, Russo GL(6), Dentice M(1), Macchia PE(1), Sinicropi MS(5), Angelone T(2, Ungaro P(4).

Publikováno v: The Journal of nutritional biochemistry (2019). doi:10.1016/j.jnutbio.2019.03.019
info:cnr-pdr/source/autori:Nettore IC (1), Rocca C (2), Mancino G (1), Albano L(3,4), Amelio D (2), Grande F(5), Puoci F(5), Pasqua T(2), Desiderio S(1), Mazza R(2), Terracciano D(3), Colao A(1), Bèguinot F(3,4), Russo GL(6), Dentice M(1), Macchia PE(1), Sinicropi MS(5), Angelone T(2,7), Ungaro P(4)./titolo:Quercetin and its derivative Q2 modulate chromatin dynamics in adipogenesis and Q2 prevents obesity and metabolic disorders in rats./doi:10.1016%2Fj.jnutbio.2019.03.019/rivista:The Journal of nutritional biochemistry/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume

Recently the attention of the scientific community has focused on the ability of polyphenols to counteract adverse epigenetic regulation involved in the development of complex conditions such as obesity. The aim of this study was to investigate the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b970139729fe289526b45b7c0ed8bad
https://doi.org/10.1016/j.jnutbio.2019.03.019

Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation.

Autor: Gastaldi S; Department of Drug Science and Technology, University of Turin, 10125, Turin, Italy., Rocca C; Cellular and Molecular Cardiovascular Pathophysiology Laboratory, Department of Biology, E. and E.S. (DiBEST), University of Calabria, 87036, Rende, Italy., Gianquinto E; Department of Drug Science and Technology, University of Turin, 10125, Turin, Italy., Granieri MC; Cellular and Molecular Cardiovascular Pathophysiology Laboratory, Department of Biology, E. and E.S. (DiBEST), University of Calabria, 87036, Rende, Italy., Boscaro V; Department of Drug Science and Technology, University of Turin, 10125, Turin, Italy., Blua F; Department of Drug Science and Technology, University of Turin, 10125, Turin, Italy., Rolando B; Department of Drug Science and Technology, University of Turin, 10125, Turin, Italy., Marini E; Department of Drug Science and Technology, University of Turin, 10125, Turin, Italy., Gallicchio M; Department of Drug Science and Technology, University of Turin, 10125, Turin, Italy., De Bartolo A; Cellular and Molecular Cardiovascular Pathophysiology Laboratory, Department of Biology, E. and E.S. (DiBEST), University of Calabria, 87036, Rende, Italy., Romeo N; Cellular and Molecular Cardiovascular Pathophysiology Laboratory, Department of Biology, E. and E.S. (DiBEST), University of Calabria, 87036, Rende, Italy., Mazza R; Cellular and Molecular Cardiovascular Pathophysiology Laboratory, Department of Biology, E. and E.S. (DiBEST), University of Calabria, 87036, Rende, Italy., Fedele F; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161, Rome, Italy; National Institute for Cardiovascular Research (INRC), Bologna, Italy., Pagliaro P; Department of Clinical and Biological Sciences, University of Turin, Turin, Italy; National Institute for Cardiovascular Research (INRC), Bologna, Italy., Penna C; Department of Clinical and Biological Sciences, University of Turin, Turin, Italy; National Institute for Cardiovascular Research (INRC), Bologna, Italy. Electronic address: claudia.penna@unito.it., Spyrakis F; Department of Drug Science and Technology, University of Turin, 10125, Turin, Italy. Electronic address: francesca.spyrakis@unito.it., Bertinaria M; Department of Drug Science and Technology, University of Turin, 10125, Turin, Italy. Electronic address: massimo.bertinaria@unito.it., Angelone T; Cellular and Molecular Cardiovascular Pathophysiology Laboratory, Department of Biology, E. and E.S. (DiBEST), University of Calabria, 87036, Rende, Italy; National Institute for Cardiovascular Research (INRC), Bologna, Italy.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2023 Sep 05; Vol. 257, pp. 115542. Date of Electronic Publication: 2023 Jun 02.