Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Angelo Toto"'
Autor:
Noah Giacon, Ettore Lo Cascio, Valeria Pennacchietti, Flavio De Maio, Giulia Santarelli, Diego Sibilia, Federica Tiberio, Maurizio Sanguinetti, Wanda Lattanzi, Angelo Toto, Alessandro Arcovito
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The COVID-19 pandemic caused by SARS-CoV-2 has highlighted the urgent need for innovative antiviral strategies to fight viral infections. Although a substantial part of the overall effort has been directed at the Spike protein to create an e
Externí odkaz:
https://doaj.org/article/1ddadc7741ce42c7a61846415285a350
Publikováno v:
Biochemistry and Biophysics Reports, Vol 39, Iss , Pp 101803- (2024)
GRB2, or Growth Factor Receptor-Bound Protein 2, is a pivotal adaptor protein in intracellular signal transduction pathways, particularly within receptor tyrosine kinase (RTK) signaling cascades. Its crystal structure reveals a modular architecture c
Externí odkaz:
https://doaj.org/article/4d1e56f4755e4ccd9e4ff1db49f9c690
Autor:
Livia Pagano, Valeria Pennacchietti, Francesca Malagrinò, Mariana Di Felice, Julian Toso, Elena Puglisi, Stefano Gianni, Angelo Toto
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6566 (2024)
The SH2 domains of SHP2 play a crucial role in determining the function of the SHP2 protein. While the folding and binding properties of the isolated NSH2 and CSH2 domains have been extensively studied, there is limited information about the tandem S
Externí odkaz:
https://doaj.org/article/394ee236421447b29ff1eb6539e7b003
Autor:
Valeria Pennacchietti, Angelo Toto
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract The Envelope protein (E) is a structural protein encoded by the genome of SARS-CoV, SARS-CoV-2 and MERS-CoV Coronaviruses. It is poorly present in the virus but highly expressed in the host cell, with prominent role in virus assembly and vir
Externí odkaz:
https://doaj.org/article/449106499cd94389871dc703cddc2c65
Autor:
Noah Giacon, Ettore Lo Cascio, Darcy S. Davidson, Marcelo D. Polêto, Justin A. Lemkul, Valeria Pennacchietti, Livia Pagano, Carlotta Zamparelli, Angelo Toto, Alessandro Arcovito
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3259-3271 (2023)
The Envelope (E) protein of SARS-CoV-2 plays a key role in virus maturation, assembly, and virulence mechanisms. The E protein is characterized by the presence of a PDZ-binding motif (PBM) at its C-terminus that allows it to interact with several PDZ
Externí odkaz:
https://doaj.org/article/5f87ea47f88e4bfda42747021ccdc226
Autor:
Awa Diop, Paola Pietrangeli, Valeria Pennacchietti, Livia Pagano, Angelo Toto, Mariana Di Felice, Sara Di Matteo, Lucia Marcocci, Francesca Malagrinò, Stefano Gianni
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17364 (2023)
Protein–protein interactions play crucial roles in a wide range of biological processes, including metabolic pathways, cell cycle progression, signal transduction, and the proteasomal system. For PPIs to fulfill their biological functions, they req
Externí odkaz:
https://doaj.org/article/151c7fffc0d0400982471db305cf60a9
Autor:
Caterina Nardella, Lorenzo Visconti, Francesca Malagrinò, Livia Pagano, Marianna Bufano, Marianna Nalli, Antonio Coluccia, Giuseppe La Regina, Romano Silvestri, Stefano Gianni, Angelo Toto
Publikováno v:
Biology Direct, Vol 16, Iss 1, Pp 1-21 (2021)
Abstract The interaction between proteins is a fundamental event for cellular life that is generally mediated by specialized protein domains or modules. PDZ domains are the largest class of protein–protein interaction modules, involved in several c
Externí odkaz:
https://doaj.org/article/79a77de6d4184643b76da2ee34efbff5
Autor:
Awa Diop, Paola Pietrangeli, Caterina Nardella, Valeria Pennacchietti, Livia Pagano, Angelo Toto, Mariana Di Felice, Sara Di Matteo, Lucia Marcocci, Francesca Malagrinò, Stefano Gianni
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10138 (2023)
SPOP (Speckle-type POZ protein) is an E3 ubiquitin ligase adaptor protein that mediates the ubiquitination of several substrates. Furthermore, SPOP is responsible for the regulation of both degradable and nondegradable polyubiquitination of a number
Externí odkaz:
https://doaj.org/article/42f25688e90745acb309a7af0b90c3af
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/a821306fec904a68817a6650e8ed57be
Autor:
Ettore Lo Cascio, Angelo Toto, Gabriele Babini, Flavio De Maio, Maurizio Sanguinetti, Alvaro Mordente, Stefano Della Longa, Alessandro Arcovito
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 1838-1847 (2021)
Short Linear Motifs (SLiMs) are functional protein microdomains that typically mediate interactions between a short linear region in one protein and a globular domain in another. Surface Plasmon Resonance assays have been performed to determine the b
Externí odkaz:
https://doaj.org/article/bf96ef5a1f9242f290b6fa6905ec77aa