Zobrazeno 1 - 10 of 43 pro vyhledávání: '"Angelo Peschiaroli"'
1
Akademický článek
Hyaluronic acid metabolism and chemotherapy resistance: recent advances and therapeutic potential
Autor: Zhanhong Liu, Pengbo Hou, Jiankai Fang, Changshun Shao, Yufang Shi, Gerry Melino, Angelo Peschiaroli
Publikováno v: Molecular Oncology, Vol 18, Iss 9, Pp 2087-2106 (2024)
Hyaluronic acid (HA) is a major component of the extracellular matrix, providing essential mechanical scaffolding for cells and, at the same time, mediating essential biochemical signals required for tissue homeostasis. Many solid tumors are characte
Externí odkaz: https://doaj.org/article/0aacebe284b94200bfd40d3f8fc447b8
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2
Akademický článek
The long non-coding RNA NEAT1 is a ΔNp63 target gene modulating epidermal differentiation
Autor: Claudia Fierro, Veronica Gatti, Veronica La Banca, Sara De Domenico, Stefano Scalera, Giacomo Corleone, Maurizio Fanciulli, Francesca De Nicola, Alessandro Mauriello, Manuela Montanaro, George A. Calin, Gerry Melino, Angelo Peschiaroli
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The transcription factor ΔNp63 regulates epithelial stem cell function and maintains the integrity of stratified epithelial tissues by acting as transcriptional repressor or activator towards a distinct subset of protein-coding genes and mi
Externí odkaz: https://doaj.org/article/eafc788a7a7545c69bc62a7a9637dd3d
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3
Akademický článek
Senataxin and R-loops homeostasis: multifaced implications in carcinogenesis
Autor: Veronica Gatti, Sara De Domenico, Gerry Melino, Angelo Peschiaroli
Publikováno v: Cell Death Discovery, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract R-loops are inherent byproducts of transcription consisting of an RNA:DNA hybrid and a displaced single-stranded DNA. These structures are of key importance in controlling numerous physiological processes and their homeostasis is tightly con
Externí odkaz: https://doaj.org/article/88ddfc1fef644a008b8103fe6bc3eec7
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4
Akademický článek
A novel oral micellar fenretinide formulation with enhanced bioavailability and antitumour activity against multiple tumours from cancer stem cells
Autor: Isabella Orienti, Valentina Salvati, Giovanni Sette, Massimo Zucchetti, Lucilla Bongiorno-Borbone, Angelo Peschiaroli, Lello Zolla, Federica Francescangeli, Mariella Ferrari, Cristina Matteo, Ezia Bello, Antonio Di Virgilio, Mario Falchi, Maria Laura De Angelis, Marta Baiocchi, Gerry Melino, Ruggero De Maria, Ann Zeuner, Adriana Eramo
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-17 (2019)
Abstract Background An increasing number of anticancer agents has been proposed in recent years with the attempt to overcome treatment-resistant cancer cells and particularly cancer stem cells (CSC), the major culprits for tumour resistance and recur
Externí odkaz: https://doaj.org/article/4a12c3bc432f4836b5239c7374f87fc0
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5
Akademický článek
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP
Autor: Francesca Bufalieri, Paola Infante, Flavia Bernardi, Miriam Caimano, Paolo Romania, Marta Moretti, Ludovica Lospinoso Severini, Julie Talbot, Ombretta Melaiu, Mirella Tanori, Laura Di Magno, Diana Bellavia, Carlo Capalbo, Stéphanie Puget, Enrico De Smaele, Gianluca Canettieri, Daniele Guardavaccaro, Luca Busino, Angelo Peschiaroli, Simonetta Pazzaglia, Giuseppe Giannini, Gerry Melino, Franco Locatelli, Alberto Gulino, Olivier Ayrault, Doriana Fruci, Lucia Di Marcotullio
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
ERAP1 is an endoplasmic reticulum aminopeptidase that trims MHC Class-I peptides for antigen presentation. Here, the authors show that ERAP1 enhances Hedgehog signalling by sequestering USP47 from βTrCP and promoting tumorigenesis through βTrCP deg
Externí odkaz: https://doaj.org/article/5fd719ba14de49b9b63737e49dcf4878
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6
Akademický článek
ΔNp63 in squamous cell carcinoma: defining the oncogenic routes affecting epigenetic landscape and tumour microenvironment
Autor: Veronica Gatti, Claudia Fierro, Margherita Annicchiarico‐Petruzzelli, Gerry Melino, Angelo Peschiaroli
Publikováno v: Molecular Oncology, Vol 13, Iss 5, Pp 981-1001 (2019)
Squamous cell carcinoma (SCC) is a treatment‐refractory tumour which arises from the epithelium of diverse anatomical sites such as oesophagus, head and neck, lung and skin. Accumulating evidence has revealed a number of genomic, clinical and molec
Externí odkaz: https://doaj.org/article/c7db757d947f4131896dfbb712927fc5
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7
Akademický článek
HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα
Autor: Anthea Di Rita, Angelo Peschiaroli, Pasquale D′Acunzo, Daniela Strobbe, Zehan Hu, Jens Gruber, Mads Nygaard, Matteo Lambrughi, Gerry Melino, Elena Papaleo, Jörn Dengjel, Said El Alaoui, Michelangelo Campanella, Volker Dötsch, Vladimir V. Rogov, Flavie Strappazzon, Francesco Cecconi
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Mitophagy is crucial for mitochondrial quality control and maintenance of cellular homeostasis. Here the authors identify an E3 ubiquitin ligase, HUWE1, that collaborates with LC3-interacting protein AMBRA1 to induce mitochondrial clearance.
Externí odkaz: https://doaj.org/article/ef54c1bc371f46c7a0abb9f445a40480
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9
ΔNp63-Senataxin circuit controls keratinocyte differentiation by promoting the transcriptional termination of epidermal genes
Autor: Veronica Gatti, Claudia Fierro, Mirco Compagnone, Veronica La Banca, Alessandro Mauriello, Manuela Montanaro, Stefano Scalera, Francesca De Nicola, Eleonora Candi, Francesco Ricci, Luca Fania, Gerry Melino, Angelo Peschiaroli
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(10)
Significance ΔNp63 is a master regulator of skin homeostasis since it finely controls keratinocyte differentiation and proliferation. Here, we provide cellular and molecular evidence demonstrating the functional role of a ΔNp63 interactor, the R-lo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87352962091661992d947c1f61fdffa3
https://pubmed.ncbi.nlm.nih.gov/35235452
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10
ΔNp63 in squamous cell carcinoma: defining the oncogenic routes affecting epigenetic landscape and tumour microenvironment
Autor: Gerry Melino, Claudia Fierro, Margherita Annicchiarico-Petruzzelli, Angelo Peschiaroli, Veronica Gatti
Publikováno v: Molecular Oncology, Vol 13, Iss 5, Pp 981-1001 (2019)
Molecular Oncology
Molecular oncology
13 (2019): 981–1001. doi:10.1002/1878-0261.12473
info:cnr-pdr/source/autori:Gatti, Veronica; Fierro, Claudia; Annicchiarico-Petruzzelli, Margherita; Melino, Gerry; Peschiaroli, Angelo/titolo:Delta Np63 in squamous cell carcinoma: defining the oncogenic routes affecting epigenetic landscape and tumour microenvironment/doi:10.1002%2F1878-0261.12473/rivista:Molecular oncology (Print)/anno:2019/pagina_da:981/pagina_a:1001/intervallo_pagine:981–1001/volume:13
Squamous cell carcinoma (SCC) is a treatment-refractory tumour which arises from the epithelium of diverse anatomical sites such as oesophagus, head and neck, lung and skin. Accumulating evidence has revealed a number of genomic, clinical and molecul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fefa12324b3142550c8da35d54297121
https://doi.org/10.1002/1878-0261.12473
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