Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Angelo O. Rosa"'
Imaging decreased brain docosahexaenoic acid metabolism and signaling in iPLA2β (VIA)-deficient mice
Autor:
Mireille Basselin, Angelo O. Rosa, Epolia Ramadan, Yewon Cheon, Lisa Chang, Mei Chen, Deanna Greenstein, Mary Wohltmann, John Turk, Stanley I. Rapoport
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 11, Pp 3166-3173 (2010)
Ca2+-independent phospholipase A2β (iPLA2β) selectively hydrolyzes docosahexaenoic acid (DHA, 22:6n-3) in vitro from phospholipid. Mutations in the PLA2G6 gene encoding this enzyme occur in patients with idiopathic neurodegeneration plus brain iron
Externí odkaz:
https://doaj.org/article/9fad41192da04a42a58e196d444b349f
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 8, Pp 2334-2340 (2010)
In vitro studies show that docosahexaenoic acid (DHA) can be released from membrane phospholipid by Ca2+-independent phospholipase A2 (iPLA2), Ca2+-independent plasmalogen PLA2 or secretory PLA2 (sPLA2), but not by Ca2+-dependent cytosolic PLA2 (cPLA
Externí odkaz:
https://doaj.org/article/a69f80b7e2bb49298265e8f26ce8c0b4
Autor:
Peter Bond, Katrina Cowan, Oleg Anichtchik, Joshua Jackson, Angelo O Rosa, Robert Fern, Gabby Bianco
Publikováno v:
Glia. 66:813-827
Early white matter (WM) changes are common in dementia and may contribute to functional decline. We here examine this phenomenon in an induced dementia model for the first time. We report a novel and selective form of myelin injury as the first manif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3f19784b4e2794052586703f2df1de
https://doi.org/10.1002/glia.23286
https://doi.org/10.1002/glia.23286
Autor:
Andrea Papale, Angelo O. Rosa
Publikováno v:
Biophysical Journal. 116:69a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5306687679f50692d9df8dae8de2cc57
https://doi.org/10.1016/j.bpj.2018.11.417
https://doi.org/10.1016/j.bpj.2018.11.417
Publikováno v:
Journal of Applied Physiology. 115:1855-1861
Acute hypoxia is thought to trigger protective responses that, in tissues like heart and carotid body, include rapid (5–10 s) suppression of Ca2+ and K+ channels. To gain insight into the mechanism for the suppression of the cardiac l-type Ca2+ cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4704d28be380824df61bc5b978b3aee4
https://doi.org/10.1152/japplphysiol.00770.2013
https://doi.org/10.1152/japplphysiol.00770.2013
Publikováno v:
Cell Calcium. 53:264-274
L-type calcium channels are modulated by a host of mechanisms that include voltage, calcium ions (Ca(2+) dependent inactivation and facilitation), cytosolic proteins (CAM, CAMKII, PKA, PKC, etc.), and oxygen radicals. Here we describe yet another Ca(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2c9f0a52cc942a495f9f23f4dbb580
https://doi.org/10.1016/j.ceca.2012.12.007
https://doi.org/10.1016/j.ceca.2012.12.007
Publikováno v:
The Journal of Physiology. 590:4223-4237
Acute and chronic hypoxias are common cardiac diseases that lead often to arrhythmia and impaired contractility. At the cellular level it is unclear whether the suppression of cardiac Ca(2+) channels (Ca(V)1.2) results directly from oxygen deprivatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4603b9a8101eb661718c6adbc4758fe
https://doi.org/10.1113/jphysiol.2012.236570
https://doi.org/10.1113/jphysiol.2012.236570
Autor:
Antonio G. García, Maria Dolores Martin-de-Saavedra, L. del Barrio, Javier Egea, Manuela G. López, Angelo O. Rosa, Esther Parada, Alejandro Romero
Publikováno v:
Neuropharmacology. 62:1082-1090
Galantamine is a drug currently used to treat Alzheimer's disease (AD); in this group of patients it has been observed that concomitant ischemic brain injury can accelerate their cognitive deficit. We have previously shown that galantamine can afford
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c6642428b3892ef1b24e9d9ab2b024
https://doi.org/10.1016/j.neuropharm.2011.10.022
https://doi.org/10.1016/j.neuropharm.2011.10.022
Autor:
Adair R.S. Santos, Manuela G. López, Leidiane Mazzardo-Martins, Francisney Pinto do Nascimento, Daniel Martins, Vinicius M. Gadotti, Angelo O. Rosa, Javier Egea
Publikováno v:
The Journal of Pain. 12:315-322
We investigated the antinociceptive effects of AR-A014418, a selective inhibitor of glycogen synthase kinase-3β (GSK-3β) in mice. A 30-minute pretreatment with AR-A014418 (.1 and 1 mg/kg, intraperitoneal [ip]) inhibited nociception induced by an ip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48a5caf6adde01857db96c1f9de7978
https://doi.org/10.1016/j.jpain.2010.06.007
https://doi.org/10.1016/j.jpain.2010.06.007
Autor:
Ulrich Zechner, Lars Cleemann, Symeon Papadopoulos, Matthias Linke, Martin Farr, Stephan Rosenkranz, Guoxing Xu, Hendrik Milting, Wilhelm Haverkamp, Susannah L. Stone, Angelo O. Rosa, Abdul Shokor Parwani, Vera Beyer, Juan José Arnáiz-Cot, Gabriele Pfitzer, Filomain Nguemo, Tomo Saric, Sven Dittmann, Azra Fatima, Hans Christian Hennies, Martin Lehmann, Kaifeng Shao, Juergen Hescheler, Matthias Matzkies, Martin Morad, Baerbel Klauke
Publikováno v:
Cellular Physiology and Biochemistry. 28:579-592
Background/Aims: Induced pluripotent stem (iPS) cells generated from accessible adult cells of patients with genetic diseases open unprecedented opportunities for exploring the pathophysiology of human diseases in vitro. Catecholaminergic polymorphic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfe134a261ef524bca6e346210186402
https://doi.org/10.1159/000335753
https://doi.org/10.1159/000335753