Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Angelo Nicolin"'
Autor:
Giuliana Gatti, Giovanna Maresca, Manuela Natoli, Fulvio Florenzano, Angelo Nicolin, Armando Felsani, Igea D'Agnano
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5442 (2009)
BackgroundThe role of the MYC oncogene in the apoptotic pathways is not fully understood. MYC has been reported to protect cells from apoptosis activation but also to sensitize cells to apoptotic stimuli. We have previously demonstrated that the down
Externí odkaz:
https://doaj.org/article/7377676b868d4f5283c5ca3a97a2249c
Autor:
Federico Di Gesualdo, Matteo Lulli, Angelo Nicolin, Francesco Bertolini, Andrea Lapucci, Martino Donnini, Ewa Witort, Nicola Schiavone, Sergio Capaccioli, Gary Brewer, Laura Papucci, Annamaria Bevilacqua, Dominique Morello, Amedeo Amedei
Publikováno v:
The FASEB Journal. 24:1852-1865
The human antiapoptotic bcl-2 gene has been discovered in t(14;18) B-cell leukemias/lymphomas because of its overexpression caused at a transcriptional control level by the bcl-2/IgH fusion gene. We were the first to disclose the post-transcriptional
Autor:
Angela Calastretti, Paola Bruno, F. Scarlatti, Gianfranco Canti, Marcella Priulla, Laura Asnaghi, Angelo Nicolin
Publikováno v:
Cellular Signalling. 19:2118-2126
Akt activation assists tumor cell survival and promotes resistance to chemotherapy. Here we show that constitutively active Akt (CA-Akt) cells are highly sensitized to cell death induced by nutrient and growth factor deprivation, whereas dominant-neg
Autor:
Marcella, Priulla, Angela, Calastretti, Paola, Bruno, Amalia, Azzariti, Azzariti, Amalia, Angelo, Paradiso, Gianfranco, Canti, Angelo, Nicolin
Publikováno v:
The Prostate. 67:782-789
BACKGROUND In prostate cancer, mutations of the phosphatase PTEN can activate the kinase cascade PI3K/Akt/mTOR which induces drug resistance. METHODS Chemosensitization by siRNA targeting Akt was studied in HEK293 cells forced to express CA-Akt or ki
Autor:
Andrea Lapucci, Angelo Nicolin, Laura Ghisolfi, Sergio Capaccioli, Gianfranco Canti, Nicola Schiavone, Laura Papucci, Giuseppe Tataranni, Annamaria Bevilacqua
Publikováno v:
Molecular Pharmacology. 68:816-821
RNA has become a promising target for pharmacological purposes. Most current strategies are directed toward down-regulating its functions. In this study, we provide evidence of the up-regulation of messenger RNA in a sequence-specific manner. The bcl
Autor:
Gary Brewer, Sergio Capaccioli, Alain Jacquier, Laura Papucci, Martino Donnini, Ewa Witort, Andrea Lapucci, Nicola Schiavone, Angelo Nicolin
Publikováno v:
Journal of Biological Chemistry. 279:20154-20166
Modulation of mRNA stability by regulatory cis-acting AU-rich elements (AREs) and ARE-binding proteins is an important posttranscriptional mechanism of gene expression control. We previously demonstrated that the 3′-untranslated region of BCL-2 mRN
Publikováno v:
Current Pharmaceutical Design. 10:769-784
Maneuvering single gene expression is not only an optimal way to study gene function but also an ambitious goal, which will lead to the treatment of a variety of human diseases whose main pathogenetic event is a genetic alteration. The recent efforts
Publikováno v:
Journal of Cellular Physiology. 195:356-372
Recent evidence suggests that gene expression may be regulated, at least in part, at post-transcriptional level by factors inducing the extremely rapid degradation of messenger RNAs. These factors include reactions between adenyl-uridyl-rich elements
Autor:
Gary Brewer, Anna Bevilacqua, Martino Donnini, Angelo Nicolin, Andrea Lapucci, Nicola Schiavone, Alessio Tempestini, Ewa Witort, Laura Papucci, Sergio Capaccioli
Publikováno v:
Biochemical and Biophysical Research Communications. 287:1063-1069
The expression of genes requiring finely tuned control is regulated by a posttranscriptional mechanism involving mRNA A + U-rich elements (AREs) cooperating with ARE-binding proteins (AUBPs) in modulation of mRNA stability. We reported previously tha
Autor:
Domenico Delia, Silvia Tomasini, Alessandro Quattrone, Sergio Capaccioli, Anna Bevilacqua, Susanna Morelli, Nicola Schiavone, Angelo Nicolin
Publikováno v:
Proceedings of the National Academy of Sciences. 94:8150-8155
In most human follicular B cell lymphomas the bcl-2 gene is up-regulated as a result of the t(14;18) chromosomal translocation generating a hybrid bcl-2–IgH mRNA. Recently, we have identified in t(14;18)-positive cells a bcl-2–IgH mRNA in the ant