Estratégias para a produção de fator VIII recombinante (FVIIIr) em uma linhagem humana em condições de cultivo livres de soro e em suspensão

Autor: Angelo Luis Caron

Publikováno v: Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.

A hemofilia A é uma doença ligada ao cromossomo X causada pela deficiência do fator VIII da coagulação sanguínea (FVIII). O tratamento disponível consiste na terapia de reposição da proteína do fator VIII derivada do plasma (FVIIIdp) ou rec

Externí odkaz: http://www.teses.usp.br/teses/disponiveis/60/60138/tde-11042017-160340/

Nanostructured lipid carrier co-delivering tacrolimus and TNF-α siRNA as an innovate approach to psoriasis

Autor: Juliana Santos Rosa Viegas, Ana Vitoria Pupo Silvestrini, Fabíola Silva Garcia Praça, Angelo Luis Caron, Isabella Suzuki, Marcelo Kravicz, Wanessa Silva Garcia Medina, José Orestes Del Ciampo, Maria Vitória Lopes Badra Bentley

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Since psoriasis is an immuno-mediated skin disease, long-term therapies are necessary for its treatment. In clinical investigations, tacrolimus (TAC), a macrolide immunosuppressive inhibitor of calcineurin, arises as an alternative for the treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9b6b201fc593c6af0f5d7e05e1eb0c
https://doi.org/10.1007/s13346-020-00723-6

Nanotechnology approaches in the current therapy of skin cancer

Autor: Angelo Luis Caron, Ana Vitoria Pupo Silvestrini, Maria Vitória Lopes Badra Bentley, Marcelo Kravicz, Fabíola Silva Garcia Praça, Lívia Neves Borgheti-Cardoso, Juliana Santos Rosa Viegas

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Dipòsit Digital de la UB
Universidad de Barcelona

Skin cancer is a high burden disease with a high impact on global health. Conventional therapies have several drawbacks; thus, the development of effective therapies is required. In this context, nanotechnology approaches are an attractive strategy f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa73a195537eb3449fd7fa215a41fef1
https://hdl.handle.net/10281/418338

Production of Lentiviral Vectors Encoding Recombinant Factor VIII Expression in Serum-Free Suspension Cultures

Autor: Sven Ansorge, Kamilla Swiech, Amine Kamen, Angelo Luis Caron, Virgínia Picanço-Castro, Dimas Tadeu Covas

Publikováno v: Brazilian Archives of Biology and Technology, Vol 58, Iss 6, Pp 923-928 (2015)
Brazilian Archives of Biology and Technology, Volume: 58, Issue: 6, Pages: 923-928, Published: DEC 2015
Brazilian Archives of Biology and Technology v.58 n.6 2015
Brazilian Archives of Biology and Technology
Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR

Lentiviral vector-mediated gene transfer offers several advantages over other gene delivery vectors when considering gene and cell therapy applications. However, using these therapies in clinical applications involves large-scale vector production in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e722afc936a86589c10295eb658a25e3
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000600923&lng=en&tlng=en

Platforms for Recombinant Therapeutic Glycoprotein Production

Autor: Amanda, Mizukami, Angelo Luis, Caron, Virgínia, Picanço-Castro, Kamilla, Swiech

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1674

The majority of FDA-approved biology-derived products are recombinant glycoproteins. These proteins have been used for the treatment of several diseases, with numerous products currently approved for clinical use. The choice of the expression system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b15b824c2c4e65e835850b1c020319c9
https://pubmed.ncbi.nlm.nih.gov/28921424