Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Angelo Grauel"'
Autor:
Emily Lee, Sarah Szvetecz, Ryan Polli, Angelo Grauel, Jayson Chen, Joyce Judge, Smita Jaiswal, Rie Maeda, Stephanie Schwartz, Bernd Voedisch, Mateusz Piksa, Chietara Japutra, Lingheswar Sadhasivam, Yiqin Wang, Ana Carrion, Sinan Isim, Jinsheng Liang, Thomas Nicholson, Hong Lei, Qing Fang, Michelle Steinkrauss, Dana Walker, Joel Wagner, Viviana Cremasco, Hui Qin Wang, Giorgio G. Galli, Brian Granda, Keith Mansfield, Quincey Simmons, Andrew Anh Nguyen, Nicole Vincent Jordan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract High-grade serous ovarian cancers (HGSOC) represent the most common subtype of ovarian malignancies. Due to the frequency of late-stage diagnosis and high rates of recurrence following standard of care treatments, novel therapies are needed
Externí odkaz:
https://doaj.org/article/43b3a91fdd2f4465a835393a7f3b1b6b
Autor:
Ye Wang, Morvarid Mohseni, Angelo Grauel, Javier Estrada Diez, Wei Guan, Simon Liang, Jiyoung Elizabeth Choi, Minying Pu, Dongshu Chen, Tyler Laszewski, Stephanie Schwartz, Jane Gu, Leandra Mansur, Tyler Burks, Lauren Brodeur, Roberto Velazquez, Steve Kovats, Bhavesh Pant, Giri Buruzula, Emily Deng, Julie T. Chen, Farid Sari-Sarraf, Christina Dornelas, Malini Varadarajan, Haiyan Yu, Chen Liu, Joanne Lim, Huai-Xiang Hao, Xiaomo Jiang, Anthony Malamas, Matthew J. LaMarche, Felipe Correa Geyer, Margaret McLaughlin, Carlotta Costa, Joel Wagner, David Ruddy, Pushpa Jayaraman, Nathaniel D. Kirkpatrick, Pu Zhang, Oleg Iartchouk, Kimberly Aardalen, Viviana Cremasco, Glenn Dranoff, Jeffrey A. Engelman, Serena Silver, Hongyun Wang, William D. Hastings, Silvia Goldoni
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-23 (2021)
Abstract SHP2 is a ubiquitous tyrosine phosphatase involved in regulating both tumor and immune cell signaling. In this study, we discovered a novel immune modulatory function of SHP2. Targeting this protein with allosteric SHP2 inhibitors promoted a
Externí odkaz:
https://doaj.org/article/aeca1d5b6b344aeabcc21b726ae4f617
Autor:
Guadalupe J Jasso, Alok Jaiswal, Mukund Varma, Tyler Laszewski, Angelo Grauel, Abdifatah Omar, Nilsa Silva, Glenn Dranoff, Jeffrey A Porter, Keith Mansfield, Viviana Cremasco, Aviv Regev, Ramnik J Xavier, Daniel B Graham
Publikováno v:
PLoS Biology, Vol 20, Iss 1, p e3001532 (2022)
Chronic inflammation is often associated with the development of tissue fibrosis, but how mesenchymal cell responses dictate pathological fibrosis versus resolution and healing remains unclear. Defining stromal heterogeneity and identifying molecular
Externí odkaz:
https://doaj.org/article/56ff678867654cd1ac04c58c9f8ec4d5
Autor:
Zheng Yan, Raphael Thierry, Antoine deWeck, Claire Fabre, Felipe Correa Geyer, Joel Wagner, Oleg Iartchouk, Jeffrey A. Engelman, Beverly Nguyen, Rohan Diwanji, James Deeds, Julie Chen, Quincey Simmons, Naiyan Chen, Viviana Cremasco, Jonathan Chang, Joseph X. Zhou, Matt Hims, Yenyen Yu, Shaobu Weng, Pushpa Jayaraman, Stephanie Schwartz, David A. Ruddy, Michelle Piquet, Vera M. Ruda, Nathaniel D. Kirkpatrick, Pavitra Chikkegowda, Mirek Dostalek, Iulian Pruteanu-Malinici, Brian Minie, Glenn Dranoff, Markus Riester, Marc Pelletier, Alina Raza, Angelo Grauel, Kenzie MacIsaac, Jincheng Wu, Tyler Laszewski
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Despite the increasing interest in targeting stromal elements of the tumor microenvironment, we still face tremendous challenges in developing adequate therapeutics to modify the tumor stromal landscape. A major obstacle to this is our poor understan
Autor:
Jayson Chen, Mateusz Piksa, Giorgio G. Galli, Smita Jaiswal, Keith Mansfield, Viviana Cremasco, Sinan Isim, Thomas B. Nicholson, Angelo Grauel, Ana Carrion, Stephanie Schwartz, Bernd Voedisch, Emily Lee, Joyce Judge, Michelle Steinkrauss, Andrew Anh Nguyen, Sarah Szvetecz, Chietara Japutra, Lingheswar Sadhasivam, Nicole Vincent Jordan, Brian Granda, Jinsheng Liang, Hong Lei, Hui Qin Wang, Dana B. Walker, Yiqin Wang, Joel Wagner, Qing Fang, Rie Maeda, Quincey Simmons, Ryan Polli
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
High-grade serous ovarian cancers (HGSOC) represent the most common subtype of ovarian malignancies. Due to the frequency of late-stage diagnosis and high rates of recurrence following standard of care treatments, novel therapies are needed to promot
Autor:
Stephen Santoro, Shilpa Keerthivasan, Viviana Cremasco, Kai W. Wucherpfennig, Lotte Spel, Matthew C. Woodruff, Jillian L. Astarita, Sara Cruz Migoni, Angelo Grauel, Michael P Wu, Martin W. LaFleur, Kenzie MacIsaac, Konstantin Knoblich, Tyler Laszewski, Michael C. Carroll, Shannon J. Turley, Ellen Puré, Anne L. Fletcher, Zohreh Amoozgar, Glenn Dranoff
Publikováno v:
Cancer Immunology Research. 6:1472-1485
Cancer-associated fibroblasts (CAFs) are generally associated with poor clinical outcome. CAFs support tumor growth in a variety of ways and can suppress antitumor immunity and response to immunotherapy. However, a precise understanding of CAF contri
Autor:
Antonios O. Aliprantis, Ulrich H. von Andrian, Viviana Cremasco, Angelo Grauel, Robert Lafyatis, Kelly Tsang, Joerg Ermann, David Alvarez, Katia Urso
Publikováno v:
JCI Insight. 1
Systemic sclerosis (SSc) is a potentially fatal autoimmune disorder with limited therapeutic options. Sclerodermatous graft versus host disease (sclGvHD), induced by transfer of B10.D2 splenocytes into BALB/c Rag2–/– mice, models an inflammatory
Autor:
Flavian D. Brown, Kenzie MacIsaac, Shannon J. Turley, Michael P Wu, Michael C. Carroll, Viviana Cremasco, Glenn Dranoff, Matthew C. Woodruff, Jillian L. Astarita, Lotte Spel, Zohreh Amoozgar, Angelo Grauel
Publikováno v:
Cancer Immunology Research. 4:IA23-IA23
Despite the reported clinical benefits of checkpoint blockade in some cancers, a large proportion of patients fail to respond, and insights from preclinical and clinical studies have indicated that therapy failure may stem from cues emanating from th