Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Angelo Gradia"'
Autor:
Angelo Gradia, Benoît Laleu, Laurène Cagnon, Mike Orchard, Sophie Houngninou-Molango, Guillaume Duboux, Freddy Heitz, Francesca Gaggini, Cedric Merlot, Patrick Page, Cedric Szyndralewiez, Laetitia Fioraso-Cartier
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:6989-6999
Pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives are new chemical entities with good and attractive druglikeness properties. A series of pyrazolo-pyrido-diazepine dione analogs demonstrated to be particularly amenable to lead optim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aee95a8c2207124860562df787e0e1a
https://doi.org/10.1016/j.bmc.2011.10.016
https://doi.org/10.1016/j.bmc.2011.10.016
Autor:
Guillaume Duboux, Sophie Houngninou-Molango, Cedric Merlot, Francesca Gaggini, Angelo Gradia, Patrick Page, Laetitia Fioraso-Cartier, Freddy Heitz, Benoît Laleu, Laurène Cagnon, Mike Orchard, Cedric Szyndralewiez
Publikováno v:
Journal of Medicinal Chemistry. 53:7715-7730
We describe the design, synthesis, and optimization of first-in-class series of inhibitors of NADPH oxidase isoform 4 (Nox4), an enzyme implicated in several pathologies, in particular idiopathic pulmonary fibrosis, a life-threatening and orphan dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477b650619687dec97bd074530449382
https://doi.org/10.1021/jm100773e
https://doi.org/10.1021/jm100773e