Výsledky vyhledávání - "Angelo Carotti"

Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease

Autor: Michele Tonelli, Marco Catto, Raimon Sabaté, Valeria Francesconi, Erik Laurini, Sabrina Pricl, Leonardo Pisani, Daniela Valeria Miniero, Grazia Maria Liuzzi, Elena Gatta, Annalisa Relini, Rosalina Gavín, Jose Antonio Del Rio, Fabio Sparatore, Angelo Carotti

Publikováno v: European Journal of Medicinal Chemistry. 250:115169

A set of twenty-five thioxanthene-9-one and xanthene-9-one derivatives, that were previously shown to inhibit cholinesterases (ChEs) and amyloid β (Aβ40) aggregation, were evaluated for the inhibition of tau protein aggregation. All compounds exhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb954dcbed2541fdbb4436bce5991df3
https://doi.org/10.1016/j.ejmech.2023.115169

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17β-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer

Autor: Rolf W. Hartmann, Chris J. van Koppen, Matthias W. Laschke, Giuseppe Felice Mangiatordi, Ahmed S. Abdelsamie, Martin Frotscher, Orazio Nicolotti, Abdelrahman Mohamed, Angelo Carotti, Arcangela Mazzini, Hanna Drzewiecka, Emanuele M. Gargano, Paweł P. Jagodziński, Sandrine Marchais-Oberwinkler

Publikováno v: ACS medicinal chemistry letters
United States
ACS Med Chem Lett
ACS medicinal chemistry letters (2021). doi:10.1021/acsmedchemlett.1c00462
info:cnr-pdr/source/autori:Emanuele M. Gargano, Abdelrahman Mohamed, Ahmed S. Abdelsamie, Giuseppe F. Mangiatordi, Hanna Drzewiecka, Pawe? P. Jagodzi?ski, Arcangela Mazzini, Chris J. van Koppen, Matthias W. Laschke, Orazio Nicolotti, Angelo Carotti, Sandrine Marchais-Oberwinkler, Rolf W. Hartmann, and Martin Frotscher/titolo:17?-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer/doi:10.1021%2Facsmedchemlett.1c00462/rivista:ACS medicinal chemistry letters/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume

[Image: see text] In the face of the clinical challenge posed by non-small cell lung cancer (NSCLC), the present need for new therapeutic approaches is genuine. Up to now, no proof existed that 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b72b1eb9a0d3948ea61df325c6e341e
https://hdl.handle.net/10033/623149

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Akademický článek

17β-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine Ortholog.

Autor: Emanuele M Gargano, Giuseppe Allegretta, Enrico Perspicace, Angelo Carotti, Chris Van Koppen, Martin Frotscher, Sandrine Marchais-Oberwinkler, Rolf W Hartmann

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0134754 (2015)

Design and synthesis of a new class of inhibitors for the treatment of osteoporosis and its comparative h17β-HSD2 and m17β-HSD2 SAR study are described. 17a is the first compound to show strong inhibition of both h17β-HSD2 and m17β-HSD2, intracel

Externí odkaz: https://doaj.org/article/0bc4d2b54c854517a63ff00bf9fcb5c9

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Akademický článek

Searching for Multi-Targeting Neurotherapeutics against Alzheimer’s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif

Autor: Leonardo Pisani, Roberta Farina, Ramon Soto-Otero, Nunzio Denora, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Estefania Mendez-Alvarez, Cosimo Damiano Altomare, Marco Catto, Angelo Carotti

Publikováno v: Molecules, Vol 21, Iss 3, p 362 (2016)

The need for developing real disease-modifying drugs against neurodegenerative syndromes, particularly Alzheimer’s disease (AD), shifted research towards reliable drug discovery strategies to unveil clinical candidates with higher therapeutic effic

Externí odkaz: https://doaj.org/article/c09f9e97369d4be098250e548664a9f5

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Akademický článek

A chemocentric approach to the identification of cancer targets.

Autor: Beáta Flachner, Zsolt Lörincz, Angelo Carotti, Orazio Nicolotti, Praveena Kuchipudi, Nikita Remez, Ferran Sanz, József Tóvári, Miklós J Szabó, Béla Bertók, Sándor Cseh, Jordi Mestres, György Dormán

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35582 (2012)

A novel chemocentric approach to identifying cancer-relevant targets is introduced. Starting with a large chemical collection, the strategy uses the list of small molecule hits arising from a differential cytotoxicity screening on tumor HCT116 and no

Externí odkaz: https://doaj.org/article/3723a4fc6cdc46bd98dc182350806210

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Akademický článek

Insights into the complex formed by matrix metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations.

Autor: Ilenia Giangreco, Gianluca Lattanzi, Orazio Nicolotti, Marco Catto, Antonio Laghezza, Francesco Leonetti, Angela Stefanachi, Angelo Carotti

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e25597 (2011)

Matrix metalloproteinases (MMP) are well-known biological targets implicated in tumour progression, homeostatic regulation, innate immunity, impaired delivery of pro-apoptotic ligands, and the release and cleavage of cell-surface receptors. Hence, th

Externí odkaz: https://doaj.org/article/0dd6ff74dd1241729dc69a686197f111

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Synthesis and Biological Evaluation of Novel Hybrid Molecules Containing Purine, Coumarin and Isoxazoline or Isoxazole Moieties

Autor: Dimitra Hadjipavlou-Litina, Aikaterini Peperidou, Angelo Carotti, Konstantinos E. Litinas, Michael G. Kallitsakis, Marco Catto

Publikováno v: The Open Medicinal Chemistry Journal

Introduction: The 1,3-dipolar cycloaddition reactions of nitrile oxides formed in situ (in the presence of NCS and Et3N) from the oximes of (purin-9-yl)acetaldehyde or (coumarinyloxy)acetaldehyde with allyloxycoumarins or 9-allylpurines, respectively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b2cf96ebb7174a9b580c18f81a0462
https://doi.org/10.2174/1874104501711010196

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Quinolino[3,4- b ]quinoxalines and pyridazino[4,3- c ]quinoline derivatives: Synthesis, inhibition of topoisomerase IIα, G-quadruplex binding and cytotoxic properties

Autor: Odra Pinato, Marco Catto, Fausta Palluotto, Barbara Gatto, Angelo Carotti, Alice Sosic, Grigoris Zoidis, Claudia Sissi

Publikováno v: European Journal of Medicinal Chemistry. 123:704-717

The quinoline motif fused with other heterocyclic systems plays an important role in the field of anticancer drug development. An extensive series of tetracyclic quinolino[3,4-b]quinoxalines N-5 or C-6 substituted with basic side chain and a limited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d41cd82204c2a219105b407fb35b8a
https://doi.org/10.1016/j.ejmech.2016.07.063

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