Stroke Causes DNA Methylation at Ncx1 Heart Promoter in the Brain Via DNMT1/MeCP2/REST Epigenetic Complex

Autor: Natascia Guida, Angelo Serani, Luca Sanguigno, Luigi Mascolo, Ornella Cuomo, Salvatore Fioriniello, Domenico Marano, Floriana Della Ragione, Serenella Anzilotti, Paola Brancaccio, Pasquale Molinaro, Giuseppe Pignataro, Lucio Annunziato, Luigi Formisano

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 6 (2024)

Background REST (Repressor‐Element 1 [RE1]‐silencing transcription factor) inhibits Na+/Ca2+exchanger‐1 (Ncx1) transcription in neurons through the binding of RE1 site on brain promoter (Br) after stroke. We identified a new putative RE1 site i

Externí odkaz: https://doaj.org/article/368c7c109bcc45fdb6e0e75da03f5e5d

The Transcriptional Complex Sp1/KMT2A by Up-Regulating Restrictive Element 1 Silencing Transcription Factor Accelerates Methylmercury-Induced Cell Death in Motor Neuron-Like NSC34 Cells Overexpressing SOD1-G93A

Autor: Natascia Guida, Luca Sanguigno, Luigi Mascolo, Lucrezia Calabrese, Angelo Serani, Pasquale Molinaro, C. Geoffrey Lau, Lucio Annunziato, Luigi Formisano

Publikováno v: Frontiers in Neuroscience, Vol 15 (2021)

Methylmercury (MeHg) exposure has been related to amyotrophic lateral sclerosis (ALS) pathogenesis and molecular mechanisms of its neurotoxicity has been associated to an overexpression of the Restrictive Element 1 Silencing Transcription factor (RES

Externí odkaz: https://doaj.org/article/89a302f1e8e84e34bd6a9666029f77d1

Contributors

Autor: Catherine E.M. Aiken, Azita Amiri, Faith L. Anderson, Arthur Argenson, Anna Arita, Hrayr Attarian, Alison Berner, Vineet Bhandari, Vishwanath Bhat, Angelo Jose Goncalves Bos, Neil A. Bradbury, Meghan L. Bucher, Jan Burns, Ilaria Campesi, Arturo Casadevall, Hossein Chiti, Dorte M. Christiansen, Beth Coad, Dolores Corella, Ellie J. Coromilas, Romina Garcia de leon, Virginia Devi-Chou, Jocelyn Dicent, Mehmet Tevfik Dorak, Gillian Einstein, Harun Fajkovic, Ferric C. Fang, Liana Fattore, Anne Fausto-Sterling, Alireza Fazeli, Dov Feldberg, Roger B. Fillingim, Flavia Franconi, Karen H. Frith, Andreas M. Fritzen, Michika Fukui, Liisa A.M. Galea, Dan Gazit, Zulma Gazit, Donato Gemmati, Josephine Giblin, Marek Glezerman, Kasun Godakumara, Sydney Gram, Antonio Guillamon, Susanne B. Haga, Jessica A. Hennessey, Masakatsu Hihara, William V. Holt, Antonia Hufnagel, Hideki Iwaguro, Tannaz Jamialahmadi, Daphna Joel, Emil Jovanov, Natsuko Kakudo, Bente Kiens, Jin Kyung Kim, Sylvia Kirchengast, Stephanie M. Kochav, Suranga P. Kodithuwakku, L.M. Kok, Peter Koopman, Zoe Krut, Atsuyuki Kuro, Ryosuke Kuroda, Satoshi Kushida, Yunjia Lai, Bonnie H. Lee, Ana Lleo, Anne-Marie Lundsgaard, Adriana C. Maggi, Satoshi Matsushita, Margaret M. McCarthy, Alice Melloni, Maurizio Meloni, Gary W. Miller, Suresh Mishra, Toshihito Mitsui, Hiroshi Mizuno, R.G.H.H. Nelissen, Petr Nickl, Tatsuya Nomura, Sabine Oertelt-Prigione, Gabriela Guimaraes Oliveira-Zumda, Jose M. Ordovas, Negin Parsamanesh, Gadi Pelled, Andrei A. Puiu, M. Natasha Rajah, Doodipala Samba Reddy, Željko Reiner, Amirhossein Sahebkar, Yoshitomo Saita, Ibis Sánchez-Serrano, Reza Sari Motlagh, Ivanka Savic, Manuela Schmidinger, Caleb M. Schmidt, Michael A. Schmidt, Radislav Sedlacek, Angelo Serani, Fidaa Shaib, Shahrokh F. Shariat, Keshav K. Singh, Satoshi Sobajima, Dustin J. Sokolowski, Marla B. Sokolowski, Simón(e) D. Sun, Zhongxin Sun, Jihyun Sung, Linn Amanda Syding, Veena Taneja, Diethard Tautz, Lisa M. Thurston, Siobhan Tierney, Veronica Tisato, Morikuni Tobita, Jessica Tollkuhn, Masanori Tsubosaka, Valter Tucci, Carme Uribe, A. Van Noort, Mikhail Votinov, Reubs J. Walsh, Elaine Y. Wan, Leire Zubiaurre-Elorza

Publikováno v: Principles of Gender-Specific Medicine ISBN: 9780323885348

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ecb3833742d2c6524e411d2266f8fcf0
https://doi.org/10.1016/b978-0-323-88534-8.09993-4

GATA3 (GATA-Binding Protein 3)/KMT2A (Lysine-Methyltransferase-2A) Complex by Increasing H3K4-3me (Trimethylated Lysine-4 of Histone-3) Upregulates NCX3 (Na + -Ca 2+ Exchanger 3) Transcription and Contributes to Ischemic Preconditioning Neuroprotection

Autor: Giuseppe Pignataro, Natascia Guida, Luigi Formisano, Paola Brancaccio, Serenella Anzilotti, Ornella Cuomo, Pasquale Molinaro, Lucio Annunziato, Angelo Serani, Luigi Mascolo

Publikováno v: Stroke. 52:3680-3691

Background and Purpose: NCX3 (Na + -Ca 2+ exchanger 3) plays a relevant role in stroke; indeed its pharmacological blockade or its genetic ablation exacerbates brain ischemic damage, whereas its upregulation takes part in the neuroprotection elicited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9cd56b0fe015c1cc2a05a59697a6687f
https://doi.org/10.1161/strokeaha.121.034637

Genetic Up-Regulation or Pharmacological Activation of the Na+/Ca2+ Exchanger 1 (NCX1) Enhances Hippocampal-Dependent Contextual and Spatial Learning and Memory

Autor: Angelo Serani, Agnese Secondo, Roselia Ciccone, Ferdinando Fiorino, Gianfranco Di Renzo, Anna Pannaccione, Beatrice Severino, Lucia D’Esposito, Lucrezia Calabrese, Serenella Anzilotti, Francesco Frecentese, Silvia Natale, Tiziana Petrozziello, A.G. Sadile, Antonio Vinciguerra, Pasquale Molinaro, Simona Cabib, Ornella Cuomo, Lucio Annunziato

Publikováno v: Molecular Neurobiology. 57:2358-2376

The Na+/Ca2+ exchanger 1 (NCX1) participates in the maintenance of neuronal Na+ and Ca2+ homeostasis, and it is highly expressed at synapse level of some brain areas involved in learning and memory processes, including the hippocampus, cortex, and am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ed5f555615022a09b241cfc7ff27c3
https://doi.org/10.1007/s12035-020-01888-4