Discovery of Novel UDP-N-Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa

Autor: Denes Haase, John W. Cuozzo, John Barker, Pia Thommes, Michael Zahn, Avery Hunt, Vasileios Roumpelakis, Ying Zhang, Emily Trimby, Elise Gadouleau, Alain Dorali, Kostas Papadopoulos, Ole A. Andersen, Christoph E. Dumelin, Christel Compper, Michelle Southey, Christopher Lumley, Eric A. Sigel, Paolo A. Centrella, Barbara Mertins, Maisie Holbrow-Wilshaw, Spencer Napier, Adele Faulkner, Magali Dejob, Timothy Gorman, Alastair L Parkes, Boudewijn Dejonge, Thomas Krulle, Ricky Cain, Jennifer Williams, Boer Deng, Olivier Barbeau, Anthony D. Keefe, Sian Evans, David F. Corbett, Donnya Etheridge, Daniel B. Stein, Ryan M Dominic, Dawn M. Troast, Xianfu Li, Rajesh Odedra, Matthew A. Clark, Anthony P Dickie, Holly T Soutter, Kate Spear, Angelo Sanzone

Publikováno v: Journal of Medicinal Chemistry. 64:14377-14425

This study describes a novel series of UDP-N-acetylglucosamine acyltransferase (LpxA) inhibitors that was identified through affinity-mediated selection from a DNA-encoded compound library. The original hit was a selective inhibitor of Pseudomonas ae

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::561a3ec469b1a8704e6a0431f9d286c1
https://doi.org/10.1021/acs.jmedchem.1c00888

A Diels-Alder Approach to a Communesin Model: A/B-Cyclization Route

Autor: Peter Somfai, Angelo Sanzone

Publikováno v: European Journal of Organic Chemistry. 2015:3441-3449

Compound 3, a model system for communesin F, was approached by using a Diels-Alder reaction for the introduction of the vicinal quaternary stereocentres. Subsequent introduction of A/B-ring system followed by D/E-ring closure gave hexacyclic system 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8fdaa6d8855c9d1952347f3b87f8550
https://doi.org/10.1002/ejoc.201500177

Basic ionic liquids based on monoquaternized 1,4-diazobicyclo[2.2.2]octane (dabco) and dicyanamide anion: Physicochemical and solvent properties

Autor: Angelo Sanzone, Cinzia Chiappe, Bernardo Melai, Giulia Valentini

Publikováno v: Pure and Applied Chemistry. 81:2035-2043

In this paper, we report on the synthesis and application of monosubstituted diazabicyclo[2.2.2]octane (dabco) cations associated with a basic anion, dicyanamide. Key properties of these salts—phase transitions, density, and conductivity—were mea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d1a9047ce4698080d666923f19fa1e1
https://doi.org/10.1351/pac-con-08-11-01

Pyrazolium- versus Imidazolium-Based Ionic Liquids: Structure, Dynamics and Physicochemical Properties

Autor: Franca Castiglione, Daniele Mendola, Andrea Mele, Angelo Sanzone, Guido Raos, Cinzia Chiappe, Antonino Famulari

Publikováno v: The journal of physical chemistry. B 117 (2013): 668–676. doi:10.1021/jp3107793
info:cnr-pdr/source/autori:Chiappe, Cinzia; Sanzone, Angelo; Mendola, Daniele; Castiglione, Franca; Famulari, Antonino; Raos, Guido; Mele, Andrea/titolo:Pyrazolium-versus Imidazolium-Based Ionic Liquids: Structure, Dynamics and Physicochemical Properties/doi:10.1021%2Fjp3107793/rivista:The journal of physical chemistry. B/anno:2013/pagina_da:668/pagina_a:676/intervallo_pagine:668–676/volume:117

Ionic liquids (ILs) composed of two different pyrazolium cations with dicyanamide and bis(trifluoromethanesulfonyl)imide anions have been synthesized and characterized by NMR, Kamlet-Taft solvatochromic parameters, conductivity and rheological measur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d7d2baf0071b02d44b3d3951579b22
https://publications.cnr.it/doc/271526

A theoretical study of the copper(I)-catalyzed 1,3-dipolar cycloaddition reaction in dabco-based ionic liquids: the anion effect on regioselectivity

Autor: Angelo Sanzone, Alberto Marra, Cinzia Chiappe, Benedetta Mennucci, Christian Silvio Pomelli

Publikováno v: Physical chemistry chemical physics : PCCP. 12(8)

The regioselectivity of copper(I)-catalyzed synthesis of 1,2,3-triazoles in dabco-based ionic liquids has been investigated at the DFT level using a supermolecular approach. The analysis of the theoretical results shows that the coordination ability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2938ded5e3838df1b99f404f3ee2228b
https://pubmed.ncbi.nlm.nih.gov/20145865