Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion.

Autor: Cockerill GS; Reviral Ltd., Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2FX, U.K., Angell RM; Sussex Drug Discovery Centre, University of Sussex, Brighton, England BN1 9QJ, U.K., Bedernjak A; Reviral Ltd., Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2FX, U.K., Chuckowree I; Sussex Drug Discovery Centre, University of Sussex, Brighton, England BN1 9QJ, U.K., Fraser I; Reviral Ltd., Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2FX, U.K., Gascon-Simorte J; Sussex Drug Discovery Centre, University of Sussex, Brighton, England BN1 9QJ, U.K., Gilman MSA; Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, United States., Good JAD; Reviral Ltd., Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2FX, U.K., Harland R; Reviral Ltd., Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2FX, U.K., Johnson SM; Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, and Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio 43205, United States., Ludes-Meyers JH; Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, United States., Littler E; Reviral Ltd., Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2FX, U.K., Lumley J; Reviral Ltd., Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2FX, U.K., Lunn G; Sussex Drug Discovery Centre, University of Sussex, Brighton, England BN1 9QJ, U.K., Mathews N; Reviral Ltd., Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2FX, U.K., McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, United States., Paradowski M; Medicines Discovery Institute, Cardiff University, Cardiff, Wales CF10 3AT, U.K., Peeples ME; Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, and Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio 43205, United States., Scott C; Reviral Ltd., Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2FX, U.K., Tait D; Reviral Ltd., Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2FX, U.K., Taylor G; The Pirbright Institute, Ash Road, Pirbright, Surrey GU24 0NF, U.K., Thom M; The Pirbright Institute, Ash Road, Pirbright, Surrey GU24 0NF, U.K., Thomas E; Reviral Ltd., Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2FX, U.K., Villalonga Barber C; Sussex Drug Discovery Centre, University of Sussex, Brighton, England BN1 9QJ, U.K., Ward SE; Medicines Discovery Institute, Cardiff University, Cardiff, Wales CF10 3AT, U.K., Watterson D; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia., Williams G; Sussex Drug Discovery Centre, University of Sussex, Brighton, England BN1 9QJ, U.K., Young P; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia., Powell K; Reviral Ltd., Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2FX, U.K.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Apr 08; Vol. 64 (7), pp. 3658-3676. Date of Electronic Publication: 2021 Mar 17.

Age and sex differences in object control skills by children ages 5 to 14.

Autor: Butterfield SA; Kinesiology and Physical Education, University of Maine, Orono 04469-5740, USA. Steve.Butterfield@umit.maine.edu, Angell RM, Mason CA

Publikováno v: Perceptual and motor skills [Percept Mot Skills] 2012 Feb; Vol. 114 (1), pp. 261-74.

Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR.

Autor: Angell RM; GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK., Angell TD, Bamborough P, Brown D, Brown M, Buckton JB, Cockerill SG, Edwards CD, Jones KL, Longstaff T, Smee PA, Smith KJ, Somers DO, Walker AL, Willson M

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Jan 01; Vol. 18 (1), pp. 324-8. Date of Electronic Publication: 2007 Oct 17.

N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics.

Autor: Bamborough P; GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK. Paul.A.Bamborough@gsk.com, Angell RM, Bhamra I, Brown D, Bull J, Christopher JA, Cooper AW, Fazal LH, Giordano I, Hind L, Patel VK, Ranshaw LE, Sims MJ, Skone PA, Smith KJ, Vickerstaff E, Washington M

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Aug 01; Vol. 17 (15), pp. 4363-8. Date of Electronic Publication: 2007 Apr 13.

Selective plasma hydrolysis of glucocorticoid gamma-lactones and cyclic carbonates by the enzyme paraoxonase: an ideal plasma inactivation mechanism.

Autor: Biggadike K; Medicinal Chemistry, Enzyme Pharmacology, Biomet Doscovery and Potein Science Units, Glaxo Wellcome Research and Development, Medicines Research Centre, Hertsfordshire, UK. kb0903@ggr.co.uk, Angell RM, Burgess CM, Farrell RM, Hancock AP, Harker AJ, Irving WR, Ioannou C, Procopiou PA, Shaw RE, Solanke YE, Singh OM, Snowden MA, Stubbs RJ, Walton S, Weston HE

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2000 Jan 13; Vol. 43 (1), pp. 19-21.