Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Angelita Rebollo"'
Autor:
Heriberto Bruzzoni-Giovanelli, Habib Zouali, Mourad Sahbatou, Benjamin Maneglier, Jean-Michel Cayuela, Angelita Rebollo, Gustavo H. Marin, Daniela Geromin, Carole Tomczak, Antonio Alberdi, Jean-Francois Deleuze, Philippe Rousselot
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 834 (2024)
The tyrosine kinase Inhibitor (TKI) imatinib is approved for the treatment of the chronic phase of chronic myeloid leukemia (CP-CML). Pharmacokinetic studies have highlighted the importance of inter-patient variability on imatinib plasma trough conce
Externí odkaz:
https://doaj.org/article/af0adb86bb494509a40f152399bc276b
Autor:
Gustavo H. Marin, Samuel Murail, Laura Andrini, Marcela Garcia, Severine Loisel, Pierre Tuffery, Angelita Rebollo
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1180 (2023)
The combination of a tumor-penetrating peptide (TPP) with a peptide able to interfere with a given protein–protein interaction (IP) is a promising strategy with potential clinical application. Little is known about the impact of fusing a TPP with a
Externí odkaz:
https://doaj.org/article/57d6c31cabd7494ca27beb38b98645d3
Autor:
Laura Andrini, Gustavo H. Marin, Ana Maria Inda, Heriberto Bruzzoni-Giovanelli, Marcela Garcia, Jorge Errecalde, Angelita Rebollo
Publikováno v:
Folia Medica, Vol 62, Iss 1, Pp 31-36 (2020)
Objective: To test cell penetrating and interfering peptide Mut3DPT-PP2A/SET in interaction between serine threonine phosphatase PP2A and its physiological inhibitor, the oncoprotein SET. Materials and methods: Adult male C3H/S-strain mice, 60 days o
Externí odkaz:
https://doaj.org/article/20b519fac5a248859704a09405a18092
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2055 (2022)
The serine/threonine phosphatase PP2A and the cysteine protease Caspase 9 are two proteins involved in physiological and pathological processes, including cancer and apoptosis. We previously demonstrated the interaction between Caspase 9 and PP2A and
Externí odkaz:
https://doaj.org/article/45bb9dbc7a1b40ecb00cd0664f6a1abb
Autor:
Chang Zhi Dong, Heriberto Bruzzoni-Giovanelli, Yanhua Yu, Karim Dorgham, Christophe Parizot, Jean Marc Zini, Jean Yves Brossas, Pierre Tuffery, Angelita Rebollo
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237110 (2020)
Serine/threonine phosphatases are responsible for modulating the activities of the protein kinases implicated in the development of several pathologies. Here we identified by a PEP-scan approach a peptide of LRRK2, a Parkinson's disease associated pr
Externí odkaz:
https://doaj.org/article/4d97c334c4de49e08f3d32c1061afd4e
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 178 (2022)
In a previous study, we have shown that PEPscan can provide a cheap and rapid means to identify candidate interfering peptides (IPs), i.e., peptides able to disrupt a target protein-protein interaction. PEPscan was shown to be effective in identifyin
Externí odkaz:
https://doaj.org/article/c25d91da474d4177b92f523dfcb0b5c0
Autor:
Eric Savier, Lorena Simon-Gracia, Frederic Charlotte, Pierre Tuffery, Tambet Teesalu, Olivier Scatton, Angelita Rebollo
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1631 (2021)
Background: The interfering peptides that block protein–protein interactions have been receiving increasing attention as potential therapeutic tools. Methods: We measured the internalization and biological effect of four bi-functional tumor-penetra
Externí odkaz:
https://doaj.org/article/7defdd8c18624527a50a355652c6e56d
Publikováno v:
Biomolecules, Vol 11, Iss 6, p 772 (2021)
PEPscan is an old approach that has recently gained renewed interest for the identification of interfering peptides (IPs), i.e., peptides able to interfere with protein–protein interactions (PPIs). Its principle is to slice a protein sequence as a
Externí odkaz:
https://doaj.org/article/034050a8b9af4a798e3596b8afae9926
Publikováno v:
Viruses, Vol 3, Iss 5, Pp 586-612 (2011)
Human immunodeficiency virus (HIV) infection is principally a mucosal disease and the gastrointestinal (GI) tract is the major site of HIV replication. Loss of CD4+ T cells and systemic immune hyperactivation are the hallmarks of HIV infection. The e
Externí odkaz:
https://doaj.org/article/6e63e8dbfe6447fe870ffda7e6f13591
Autor:
Nadine N'Dilimabaka, Zacharie Taoufiq, Sergine Zougbédé, Serge Bonnefoy, Audrey Lorthiois, Pierre Oliver Couraud, Angelita Rebollo, Georges Snounou, Dominique Mazier, Alicia Moreno Sabater
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90692 (2014)
The factors implicated in the transition from uncomplicated to severe clinical malaria such as pulmonary oedema and cerebral malaria remain unclear. It is known that alterations in vascular integrity due to endothelial cell (EC) activation and death
Externí odkaz:
https://doaj.org/article/3a036a3948e340aa8a95ca153c1d9e7d