Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Angelique van den Heuvel"'
High-throughput 3D microvessel-on-a-chip model to study defective angiogenesis in systemic sclerosis
Autor:
Bart Kramer, Claudio Corallo, Angelique van den Heuvel, Justin Crawford, Thomas Olivier, Edo Elstak, Nicola Giordano, Paul Vulto, Henriette L. Lanz, Richard A. J. Janssen, Michela A. Tessari
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract In early systemic sclerosis (Scleroderma, SSc), the vasculature is impaired. Although the exact etiology of endothelial cell damage in SSc remains unclear, it is hypothesized that endothelial to mesenchymal transition (EndoMT) plays a key ro
Externí odkaz:
https://doaj.org/article/b86b2506caae477e830bdb7df0ff544d
Autor:
Henriëtte L. Lanz, Angelique van den Heuvel, Remi Dulize, Thomas Olivier, Carine Poussin, Marjolein Vermeer, Bart Kramer, Manuel C. Peitsch, Karine Baumer, Emmanuel Guedj, Alexandra Laurent, Nikolai V. Ivanov, Jos Joore, Dariusz Peric, Julia Hoeng
Publikováno v:
ALTEX. 37(1)
Lifestyle and genetic factors can lead to the development of atherosclerosis and, ultimately, cardiovascular adverse events. Rodent models are commonly used to investigate mechanism(s) of atherogenesis. However, the 3Rs principles, aiming to limit an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0b48a4df635767e340a8d81d98c58b
https://pubmed.ncbi.nlm.nih.gov/31445503
https://pubmed.ncbi.nlm.nih.gov/31445503
Autor:
Andreas Rentsch, Manoj Kulkarni, Dorit Hoffmann, Marius Ueffing, Dragana Trifunović, François Paquet-Durand, Angelique van den Heuvel, Patricia Veiga-Crespo, Thomas Euler, Eleonora Vighi, Arie Reijerkerk, Torsten Strasser, Pieter J. Gaillard, Frank Schwede, Valeria Marigo, Evelina Bertolotti, Per Ekström, Tobias Peters, Ayse Sahaboglu, Hans G. Genieser
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Development of treatments for hereditary degeneration of the retina (RD) is hampered by the vast genetic heterogeneity of this group of diseases and by the delivery of the drug to an organ protected by the blood–retina barrier. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3dedb4808a760437fa5d0992b44282
https://pubmed.ncbi.nlm.nih.gov/29531030
https://pubmed.ncbi.nlm.nih.gov/29531030
Publikováno v:
Perspectives on Medical Education
Perspectives on Medical Education, 4(3), 119-27. Springer, Cham
Perspectives on Medical Education, 4(3), 119-27. Springer, Cham
Cognitive Load Theory (CLT) has started to find more applications in medical education research. Unfortunately, misconceptions such as lower cognitive load always being beneficial to learning and the continued use of dated concepts and methods can re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c840259df4d9e5649b56700fbfdae6f
https://cris.maastrichtuniversity.nl/en/publications/4ada57aa-8f7a-4fb8-a561-a7f05a63e284
https://cris.maastrichtuniversity.nl/en/publications/4ada57aa-8f7a-4fb8-a561-a7f05a63e284
Autor:
Robin Hartman, David Maussang, Linda Chen, Joan van Kregten, Angelique van den Heuvel, Marco de Boer, Jaap Rip, Arie Reijerkerk, Pieter J. Gaillard, Elizabeth C. M. de Lange, Chantal C.M. Appeldoorn, Burt van der Boom
Publikováno v:
Journal of Drug Targeting
Partly due to poor blood–brain barrier drug penetration the treatment options for many brain diseases are limited. To safely enhance drug delivery to the brain, glutathione PEGylated liposomes (G-Technology®) were developed. In this study, in rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07076e5b7de4af9a66ab74574a5f164
https://doi.org/10.3109/1061186x.2014.888070
https://doi.org/10.3109/1061186x.2014.888070
Autor:
Susanne M. A. van der Pol, Marco de Boer, Burt van der Boom, David Maussang, Helga E. de Vries, Angelique van den Heuvel, Arie Reijerkerk, Joan van Kregten, Pieter J. Gaillard, Jaap Rip, Linda Chen
Publikováno v:
Maussang, D, Rip, J, van Kregten, J, van den Heuvel, A, van der Pol, S, van der Boom, B, Reijerkerk, A, Chen, L, de Boer, M, Gaillard, P & de Vries, H 2016, ' Glutathione conjugation dose-dependently increases brain-specific liposomal drug delivery in vitro and in vivo ', Drug Discovery Today: Technologies, vol. 20, pp. 59-69 . https://doi.org/10.1016/j.ddtec.2016.09.003
The blood–brain barrier (BBB) represents a major obstacle for the delivery and development of drugs curing brain pathologies. However, this biological barrier presents numerous endogenous specialized transport systems that can be exploited by engin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44bc746b0c2f82d4d9bed20d47adbafe
https://pubmed.ncbi.nlm.nih.gov/27986226
https://pubmed.ncbi.nlm.nih.gov/27986226