Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Angelique W Whitehurst"'
Autor:
Chun-Chun Cheng, Joshua Wooten, Zane A Gibbs, Kathleen McGlynn, Prashant Mishra, Angelique W Whitehurst
Publikováno v:
eLife, Vol 9 (2020)
Cancer testis antigens (CTAs) are proteins whose expression is normally restricted to the testis but anomalously activated in human cancer. In sperm, a number of CTAs support energy generation, however, whether they contribute to tumor metabolism is
Externí odkaz:
https://doaj.org/article/fa302cdb96854203bac5ef796fb3c7f3
Autor:
Zane A Gibbs, Luis C Reza, Chun-Chun Cheng, Jill M Westcott, Kathleen McGlynn, Angelique W Whitehurst
Publikováno v:
eLife, Vol 9 (2020)
Cancer/testis (CT) antigens are proteins whose expression is normally restricted to germ cells yet aberrantly activated in tumors, where their functions remain relatively cryptic. Here we report that ZNF165, a CT antigen frequently expressed in tripl
Externí odkaz:
https://doaj.org/article/206beeac7fad4514aaa75f9b1c6b0dc5
Autor:
Angelique W. Whitehurst, John B. MacMillan, John D. Minna, Anthony J. Davis, Bruce A. Posner, Ignacio I. Wistuba, Jaime Rodriguez-Canales, Pamela A. Villalobos, Sydnie A. LaDuke, Prema L. Mallipeddi, Janapriya Saha, Min S. Kim, Jingsheng Yan, Kathleen McGlynn, Elizabeth A. McMillan, Nathaniel W. Oswald, Brandt A. Nichols
Figure S1- Piericidin A and HORMAD1 association identified by NPF screen; Figure S2- Piericidin A induces DNA damage in NSCLC lines; Figure S3- S2N and geneset overlaps for HORMAD1 high LUAD tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee52d7a62cbdfc6fd5c220bfb487a8e
https://doi.org/10.1158/0008-5472.22419254.v1
https://doi.org/10.1158/0008-5472.22419254.v1
Autor:
Angelique W. Whitehurst, John B. MacMillan, John D. Minna, Anthony J. Davis, Bruce A. Posner, Ignacio I. Wistuba, Jaime Rodriguez-Canales, Pamela A. Villalobos, Sydnie A. LaDuke, Prema L. Mallipeddi, Janapriya Saha, Min S. Kim, Jingsheng Yan, Kathleen McGlynn, Elizabeth A. McMillan, Nathaniel W. Oswald, Brandt A. Nichols
Top 10% (251 genes) identified by S2N analysis to be upregulated in HORMAD1 high LUAD tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0691c16f34881d9c5389b7bd030ea0
https://doi.org/10.1158/0008-5472.22419251.v1
https://doi.org/10.1158/0008-5472.22419251.v1
Autor:
Angelique W. Whitehurst, John B. MacMillan, John D. Minna, Anthony J. Davis, Bruce A. Posner, Ignacio I. Wistuba, Jaime Rodriguez-Canales, Pamela A. Villalobos, Sydnie A. LaDuke, Prema L. Mallipeddi, Janapriya Saha, Min S. Kim, Jingsheng Yan, Kathleen McGlynn, Elizabeth A. McMillan, Nathaniel W. Oswald, Brandt A. Nichols
Cancer testis antigens (CTA) are expressed in testis and placenta and anomalously activated in a variety of tumors. The mechanistic contribution of CTAs to neoplastic phenotypes remains largely unknown. Using a chemigenomics approach, we find that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13e02cfdca313e965a248c18244d9df
https://doi.org/10.1158/0008-5472.c.6510329.v1
https://doi.org/10.1158/0008-5472.c.6510329.v1
Autor:
Angelique W. Whitehurst, John B. MacMillan, John D. Minna, Anthony J. Davis, Bruce A. Posner, Ignacio I. Wistuba, Jaime Rodriguez-Canales, Pamela A. Villalobos, Sydnie A. LaDuke, Prema L. Mallipeddi, Janapriya Saha, Min S. Kim, Jingsheng Yan, Kathleen McGlynn, Elizabeth A. McMillan, Nathaniel W. Oswald, Brandt A. Nichols
More detailed methods for the Natural Product Library Generation, Natural Product Cytotoxicity Screens, Purification and Characterization of HORMAD1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f244a7f68f0d832d05cb42039b7f73
https://doi.org/10.1158/0008-5472.22419248.v1
https://doi.org/10.1158/0008-5472.22419248.v1
Autor:
Angelique W. Whitehurst, Kathryn M. Cappell, Patrick Taus, Daniela Mytsa, Brittany Larson, Leah Winters, Rebecca Sinnott
PDF - 195K, Supplementary figure 1 displays micronucleation of paclitaxel resistant NSCLC cells, fate mapping of micronucleated HCC366 cells, and the scheme and full data set results from the pan-genomic screen. Supplementary figure 2 provides raw da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193be06cdf673f17210f89a4c4489cba
https://doi.org/10.1158/0008-5472.22400108
https://doi.org/10.1158/0008-5472.22400108
Autor:
Angelique W. Whitehurst, Kathryn M. Cappell, Patrick Taus, Daniela Mytsa, Brittany Larson, Leah Winters, Rebecca Sinnott
AVI - 127K, Video of a HCC366 micronucleated cell undergoing mitosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3409345709dadca9fb184487565b0837
https://doi.org/10.1158/0008-5472.22400102
https://doi.org/10.1158/0008-5472.22400102
Autor:
Angelique W. Whitehurst, Kathryn M. Cappell, Patrick Taus, Daniela Mytsa, Brittany Larson, Leah Winters, Rebecca Sinnott
Non–small cell lung cancer (NSCLC) is notorious for its paltry responses to first-line therapeutic regimens. In contrast to acquired chemoresistance, little is known about the molecular underpinnings of the intrinsic resistance of chemo-naïve NSCL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc9cfda972fa5058b0adec0adc99ba26
https://doi.org/10.1158/0008-5472.c.6505499
https://doi.org/10.1158/0008-5472.c.6505499
Autor:
Angelique W. Whitehurst, Kathryn M. Cappell, Patrick Taus, Daniela Mytsa, Brittany Larson, Leah Winters, Rebecca Sinnott
XLSX - 4269K, Supplementary Table 1 lists viability scores from the pan-genomic siRNA screen. Supplementary Table 2 lists the high interest chemosensitizers and indicates those siRNA pools selected for secondary screening analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28865fbb2cd9611846d69ddcd6e2aecd
https://doi.org/10.1158/0008-5472.22400105
https://doi.org/10.1158/0008-5472.22400105