Variation at the paraoxonase gene locus contributes to carotid arterial wall thickness in subjects with familial hypercholesterolemia

Autor: F.R. Leus, Hieronymus A.M. Voorbij, John J.P. Kastelein, Arjan D. Barendrecht, Mark Roest, Angelique C.M. Jansen

Publikováno v: Clinical biochemistry, 38(2), 123-127. Elsevier Inc.

Objectives: Paraoxonase (PON1) is a potent enzyme, physically associated with the high-density lipoprotein particle. PON1 may protect against cardiovascular disease (CVD), since it is capable of hydrolyzing oxidized LDL-cholesterol, thereby negating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa4e9113878bd0408f147025b7a35ed
https://doi.org/10.1016/j.clinbiochem.2004.10.005

Metabolic syndrome and risk of coronary, cerebral, and peripheral vascular disease in a large Dutch population with familial hypercholesterolemia

Autor: Mieke D. Trip, John J.P. Kastelein, Emily S. van Aalst-Cohen, Jamal S. Rana, Angelique C.M. Jansen, Aeilko H. Zwinderman, Max Nieuwdorp, J. Wouter Jukema

Publikováno v: Diabetes care, 29(5), 1125-1127. American Diabetes Association Inc.

Various studies (1–16) in recent years have reported that the metabolic syndrome is associated with an increase in cardiovascular disease (CVD). However, there is still an uncertainty about the clinical importance and consequences of the metabolic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03435c61cd715f4ad63f84e733901665
https://doi.org/10.2337/dc05-2530

Diagnosing familial hypercholesterolaemia: the relevance of genetic testing

Autor: Mieke D. Trip, John J.P. Kastelein, P. J. Lansberg, Emily S. van Aalst-Cohen, Michael W.T. Tanck, Joep C. Defesche, Anton F. H. Stalenhoef, Angelique C.M. Jansen

Publikováno v: European Heart Journal, 27, 18, pp. 2240-6
European Heart Journal, 27, 2240-6
European heart journal, 27(18), 2240-2246. Oxford University Press

Contains fulltext : 50569.pdf (Publisher’s version ) (Closed access) AIMS: We assembled a cohort of patients with familial hypercholesterolaemia (FH) for both basic and clinical research. We used a set of established diagnostic criteria to define F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d66d09535041bbc6cc9df793e80b4c
https://hdl.handle.net/2066/50569

Genetic determinants of plasma HDL-cholesterol levels in familial hypercholesterolemia

Autor: Angelique C.M. Jansen, Michael W.T. Tanck, John J.P. Kastelein, Joep C. Defesche, Emily S. van Aalst-Cohen, Marcel Fontecha, S. Matthijs Boekholdt, Suzanne Cheng, Jan Albert Kuivenhoven, Jia Li

Publikováno v: European journal of human genetics, 13(10), 1137-1142. Nature Publishing Group

The objective of this study was to determine the extent to which common genetic variants can explain the variation of high-density lipoprotein cholesterol (HDL-C) plasma levels in familial hypercholesterolemia (FH). FH is characterized by elevated lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac018cdac1ab3cffdf94ec8af5baba2
https://pure.amc.nl/en/publications/genetic-determinants-of-plasma-hdlcholesterol-levels-in-familial-hypercholesterolemia(2f4299c5-9c05-4877-9aac-d27dc472dd6b).html

The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients

Autor: Eric J.G. Sijbrands, H. W O Roeters Van Lennep, P. J. Lansberg, Michael W.T. Tanck, John J.P. Kastelein, E. S. Van Aalst‐Cohen, Angelique C.M. Jansen, Mieke D. Trip, Anho Liem

Publikováno v: Journal of internal medicine, 256(6), 482-490. Wiley-Blackwell
Journal of Internal Medicine, 256, 482-490. Wiley-Blackwell Publishing Ltd

Objective. To determine the contribution of classical risk factors to the development of cardiovascular disease (CVD) in patients with heterozygous familial hypercholesterolaemia (FH). Design. A retrospective, multi-centre, cohort study. Extensive da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0144c2a84d3fd69a52fbaad53b878a
https://pure.amc.nl/en/publications/the-contribution-of-classical-risk-factors-to-cardiovascular-disease-in-familial-hypercholesterolaemia-data-in-2400-patients(da3889c4-beb5-44b8-94f3-c07dd01f6da9).html