Výsledky vyhledávání - "Angeline E Gavard"

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

Autor: Marcin Bielinski, Hannah T Baddock, J.A. Newman, S.M.M. Mukhopadhyay, Peter J. McHugh, Christopher J. Schofield, Opher Gileadi, Angeline E Gavard, Adam A Dannerfjord, Yuliana Yosaatmadja

Publikováno v: Nucleic Acids Research

Artemis (SNM1C/DCLRE1C) is an endonuclease that plays a key role in development of B- and T-lymphocytes and in dsDNA break repair by non-homologous end-joining (NHEJ). Artemis is phosphorylated by DNA-PKcs and acts to open DNA hairpin intermediates g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c17e074069329b662c5ea0feaf7a5aa
https://doi.org/10.1093/nar/gkab693

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Crystal Structure of the Werners Syndrome Helicase

Autor: Ravichandran Mc, Mark Petronczki, Matthias Samwer, Jark Böttcher, Klaus Rumpel, Opher Gileadi, Leonhard Geist, J.A. Newman, Engen, Katja Hauer, Patrick Werni, Angeline E Gavard, Simone Lieb

Werner syndrome helicase (WRN) plays important roles in multiple pathways of DNA repair and the maintenance of genome integrity. Germline mutations in WRN give rise to Werner syndrome, a rare autosomal recessive progeroid syndrome that also features

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76606eaeba86ec1aeabbf3224a87a361

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Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers

Autor: J.A. Newman, Katja Hauer, Klaus Rumpel, Opher Gileadi, Patrick Werni, Madhwesh C Ravichandran, Angeline E Gavard, John R. Engen, Jark Böttcher, Simone Lieb, Leonhard Geist, Mark Petronczki, Matthias Samwer

Publikováno v: Life Science Alliance

WRN is a key drug target for cancers with microsatellite instability. A crystal structure of the helicase domain of WRN identifies its unique features and provides a basis for structure-guided design of inhibitors.
Loss of WRN, a DNA repair heli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8537331a31ae7f2dac10e861eafb5cae
https://doi.org/10.26508/lsa.202000795

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The structural basis for forkhead box family specificity revealed by the crystal structure of human FOXN1 in complex with DNA

Autor: J.A. Newman, Adam E. Handel, Georg A. Holländer, Aitkenhead H, Opher Gileadi, Ioanna A. Rota, Angeline E Gavard

SignificanceFOXN1 is a transcription factor that is essential for the development of the thymus and the production of T-lymphocytes. It is a member of a large family of transcription factors which recognize DNA sequences through the conserved Forkhea

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