Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Angelina T, Regua"'
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Rearranged during transfection (RET) receptor tyrosine kinase was first identified over thirty years ago as a novel transforming gene. Since its discovery and subsequent pathway characterization, RET alterations have been identified in numerous cance
Externí odkaz:
https://doaj.org/article/6f6137dc92574ac1af894e319c6f7090
Autor:
Tadas K. Rimkus, Austin B. Arrigo, Dongqin Zhu, Richard L. Carpenter, Sherona Sirkisoon, Daniel Doheny, Angelina T. Regua, Grace L. Wong, Sara Manore, Calvin Wagner, Hui-Kuan Lin, Guangxu Jin, Jimmy Ruiz, Michael Chan, Waldemar Debinski, Hui-Wen Lo
Publikováno v:
Cancer Lett
Whether tumor suppressor candidate 2 (TUSC2) plays an important role in glioblastoma (GBM) progression is largely unknown. Whether TUSC2 undergoes polyubiquitination is unknown. Herein, we report that TUSC2 protein expression is reduced/lost in GBM c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919d1602303d3b2100122e04793288c7
https://doi.org/10.1016/j.canlet.2022.01.029
https://doi.org/10.1016/j.canlet.2022.01.029
Publikováno v:
Cancer Lett
Transgenic breast cancer mouse models are critical tools for preclinical studies of human breast cancer. Genetic editing of the murine mammary gland allows for modeling of abnormal genetic events frequently found in human breast cancers. Genetically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb59c25746d200d82030ae8dbf2f838
https://doi.org/10.1016/j.canlet.2021.05.027
https://doi.org/10.1016/j.canlet.2021.05.027
Publikováno v:
Cancers. 15:2455
Tumor Suppressor Candidate 2 (TUSC2) was first discovered as a potential tumor suppressor gene residing in the frequently deleted 3p21.3 chromosomal region. Since its discovery, TUSC2 has been found to play vital roles in normal immune function, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e67eb379252d3f75df5d21830982245b
https://doi.org/10.3390/cancers15092455
https://doi.org/10.3390/cancers15092455
Publikováno v:
Cancer Research. 83:3769-3769
HER2-enriched breast cancer and triple-negative breast cancer (TNBC) have the highest propensity to metastasize to the brain; patients with breast cancer brain metastasis (BCBM) survive only 6-18 months after diagnosis. Mechanisms that drive brain me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cffaf8b1578b24f2353d56636fd8adfc
https://doi.org/10.1158/1538-7445.am2023-3769
https://doi.org/10.1158/1538-7445.am2023-3769
Autor:
Sherona R. Sirkisoon, Grace L. Wong, Noah R. Aguayo, Daniel L. Doheny, Dongqin Zhu, Angelina T. Regua, Austin Arrigo, Sara G. Manore, Calvin Wagner, Alexandra Thomas, Ravi Singh, Fei Xing, Guangxu Jin, Kounosuke Watabe, Hui-Wen Lo
Publikováno v:
Cancer letters. 540
Mechanisms underlying breast cancer brain metastasis (BCBM) are still unclear. In this study, we observed that extracellular vesicles (EVs) secreted from breast cancer cells with increased expression of tGLI1, a BCBM-promoting transcription factor, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ede8d74452917e1ca5af29574889c27
https://pubmed.ncbi.nlm.nih.gov/35589002
https://pubmed.ncbi.nlm.nih.gov/35589002
Publikováno v:
Genes. 13:2065
Human epidermal growth factor receptor 2 (HER2) receptor tyrosine kinase is overexpressed in 20–30% of breast cancers and is associated with poor prognosis and worse overall patient survival. Most women with HER2-positive breast cancer receive neoa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::424ede6d533d6e391524449b4945200c
https://doi.org/10.3390/genes13112065
https://doi.org/10.3390/genes13112065
Autor:
Angelina T. Regua, Grace L. Wong, Austin Arrigo, Sara Abu Jalboush, Jiayuh Lin, Alexandra Thomas, Jimmy Ruiz, Roy E. Strowd, Sara G. Manore, Daniel Doheny, Yang Yu, Noah R. Aguayo, Dongqin Zhu, Calvin J. Wagner, Guangxu Jin, Peiqing Sun, Michael D. Chan, Hui-Wen Lo
Publikováno v:
Cancers
Cancers, Vol 13, Iss 2340, p 2340 (2021)
Volume 13
Issue 10
Cancers, Vol 13, Iss 2340, p 2340 (2021)
Volume 13
Issue 10
JAK2–STAT3 and TrkA signaling pathways have been separately implicated in aggressive breast cancers
however, whether they are co-activated or undergo functional interaction has not been thoroughly investigated. Herein we report, for the first
however, whether they are co-activated or undergo functional interaction has not been thoroughly investigated. Herein we report, for the first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca55504ccc6cefa2f5d7909c922d017
https://pubmed.ncbi.nlm.nih.gov/34066153
https://pubmed.ncbi.nlm.nih.gov/34066153
Autor:
Daniel Doheny, Sara Manore, Grace L. Wong, Dongqin Zhu, Sherona Sirkisoon, Marlyn Anguelov, Noah R. Augayo, Angelina T. Regua, Anderson Cox, Cristina Furdui, Terrence Smalley, Alexandra Thomas, Adrianna Masters, Roy E. Strowd, Hui-Wen Lo
Publikováno v:
Cancer Research. 82:2433-2433
Breast cancer is the second leading cause of brain metastases in women; patients with breast cancer brain metastasis (BCBM) survive only 6-18 months after diagnosis. Novel agents that act on targetable driver mutations (EGFR, PI3K, etc.) and penetrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8517d981289dbc699cc1614dbc6ff842
https://doi.org/10.1158/1538-7445.am2022-2433
https://doi.org/10.1158/1538-7445.am2022-2433
Autor:
Sara G. Manore, Daniel L. Doheny, Dongqin Zhu, Grace L. Wong, Angelina T. Regua, Austin Arrigo, Calvin J. Wagner, Mariana Najjar, Hui-Wen Lo
Publikováno v:
Cancer Research. 82:92-92
Breast cancer is the most frequently diagnosed cancer and second leading cause of cancer-related deaths in women; 30% of primary breast cancer cases will develop distant metastases. The majority (90%) of breast cancer-related deaths are due to distan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::123cb1e672e26c326404868fb17f60ec
https://doi.org/10.1158/1538-7445.am2022-92
https://doi.org/10.1158/1538-7445.am2022-92