Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Angelina Ramirez-Navarro"'
Autor:
Jyotsna Joshi, Neill Schwieterman, Nate Smole, Shuliang Guo, Xiaoping Wan, Angelina Ramirez-Navarro, Cemantha Lane, Isabelle Deschenes, Thomas Hund, Loren Wold, Sakima Smith
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 139-140 (2024)
OBJECTIVES/GOALS: The cytoskeletal protein α²II spectrin interacts with actin and ankyrin-2 in cardiomyocytes which is essential to orchestrate ion channels and membrane proteins in the cardiac dyad. Our goal is to understand molecular mechanism ca
Externí odkaz:
https://doaj.org/article/ca98c68e08e64394814658f0c599693d
Autor:
Yang Zheng, Xiaoping Wan, Dandan Yang, Angelina Ramirez-Navarro, Haiyan Liu, Ji-Dong Fu, Isabelle Deschênes
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Nav1.5, encoded by the gene SCN5A, is the predominant voltage-gated sodium channel expressed in the heart. It initiates the cardiac action potential and thus is crucial for normal heart rhythm and function. Dysfunctions in Nav1.5 have been involved i
Externí odkaz:
https://doaj.org/article/6c486a91cdbd402ea3d8c7514304b5fd
Autor:
Drew M Nassal, Xiaoping Wan, Haiyan Liu, Danielle Maleski, Angelina Ramirez-Navarro, Christine S Moravec, Eckhard Ficker, Kenneth R Laurita, Isabelle Deschênes
Publikováno v:
eLife, Vol 6 (2017)
Arrhythmogenesis from aberrant electrical remodeling is a primary cause of death among patients with heart disease. Amongst a multitude of remodeling events, reduced expression of the ion channel subunit KChIP2 is consistently observed in numerous ca
Externí odkaz:
https://doaj.org/article/b6bb4391289341408afd11106adb8d98
Autor:
Shiqiao Ye, Cankun Wang, Zhaohui Xu, Hui Lin, Xiaoping Wan, Yang Yu, Subhodip Adhicary, Joe Z. Zhang, Yang Zhou, Chun Liu, Matthew Alonzo, Jianli Bi, Angelina Ramirez-Navarro, Isabelle Deschenes, Qin Ma, Vidu Garg, Joseph C. Wu, Ming-Tao Zhao
Publikováno v:
Circulation Research. 132:187-204
Background: NOTCH1 pathogenic variants are implicated in multiple types of congenital heart defects including hypoplastic left heart syndrome, where the left ventricle is underdeveloped. It is unknown how NOTCH1 regulates human cardiac cell lineage d
Autor:
Yang Zheng, Angelina Ramirez-Navarro, Haiyan Liu, Snizhana Chorna, Xiaoping Wan, Isabelle Deschenes
Publikováno v:
Biophysical Journal. 122:174a
Autor:
Xiaoping Wan, Christine S. Moravec, Drew M. Nassal, Angelina Ramirez-Navarro, Isabelle Deschenes, Sam Chai, Haiyan Liu
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 312:H1144-H1153
Two-pore K+ (K2p) channels have been described in modulating background conductance as leak channels in different physiological systems. In the heart, the expression of K2p channels is heterogeneous with equivocation regarding their functional role.
Autor:
Eckhard Ficker, Xiaoping Wan, Angelina Ramirez-Navarro, Alfred L. George, Isabelle Deschenes, Paul J. Tesar, Sam Chai, Elizabeth S. Kaufman
Publikováno v:
The Journal of clinical investigation. 128(3)
Congenital long QT syndrome (LQTS) is an inherited channelopathy associated with life-threatening arrhythmias. LQTS type 2 (LQT2) is caused by mutations in KCNH2, which encodes the potassium channel hERG. We hypothesized that modifier genes are partl
Autor:
Sam, Chai, Xiaoping, Wan, Drew M, Nassal, Haiyan, Liu, Christine S, Moravec, Angelina, Ramirez-Navarro, Isabelle, Deschênes
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 312(6)
Two-pore K+ (K2p) channels are traditionally regarded as merely background leak channels in myriad physiological systems. Here, we describe the expression profile of K2p channels in human-induced pluripotent stem cell-derived cardiomyocytes and outli
Autor:
Isabelle Deschenes, Haiyan Liu, Drew M. Nassal, Eckhard Ficker, Xiaoping Wan, Angelina Ramirez-Navarro, Kenneth R. Laurita, Danielle Maleski, Christine S. Moravec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2daa0bd59a25a00467e191dd7a27185
https://doi.org/10.7554/elife.17304.018
https://doi.org/10.7554/elife.17304.018
Autor:
Xiaoping Wan, Danielle Maleski, Isabelle Deschenes, Kenneth R. Laurita, Christine S. Moravec, Drew M. Nassal, Eckhard Ficker, Haiyan Liu, Angelina Ramirez-Navarro
Publikováno v:
Circulation Research. 119
Introduction: Arrhythmogenesis is the primary cause of death in patients with acquired heart disease, and is the consequence of profound dysregulation of both depolarizing and repolarizing currents. Reduction in expression of the auxiliary subunit K+