Výsledky vyhledávání - "Angelina Lesnikova"

Akademický článek

Perineuronal Net Receptor PTPσ Regulates Retention of Memories

Autor: Angelina Lesnikova, Plinio Casarotto, Rafael Moliner, Senem Merve Fred, Caroline Biojone, Eero Castrén

Publikováno v: Frontiers in Synaptic Neuroscience, Vol 13 (2021)

Perineuronal nets (PNNs) have an important physiological role in the retention of learning by restricting cognitive flexibility. Their deposition peaks after developmental periods of intensive learning, usually in late childhood, and they help in lon

Externí odkaz: https://doaj.org/article/03f5fb0774d44aa4a2294dc29547f850

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Akademický článek

TrkB-ICD Fragment, Originating From BDNF Receptor Cleavage, Is Translocated to Cell Nucleus and Phosphorylates Nuclear and Axonal Proteins

Autor: João Fonseca-Gomes, André Jerónimo-Santos, Angelina Lesnikova, Plinio Casarotto, Eero Castrén, Ana M. Sebastião, Maria J. Diógenes

Publikováno v: Frontiers in Molecular Neuroscience, Vol 12 (2019)

The signaling of brain-derived neurotrophic factor (BDNF) has been suggested to be impaired in Alzheimer’s disease (AD), which may compromise the function of BDNF upon neuronal activity and survival. Accordingly, decreased levels of BDNF and its tr

Externí odkaz: https://doaj.org/article/b7feb1490bf64e4eb058b649599c6989

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nNOS-induced tyrosine nitration of TRKB impairs BDNF signaling and restrains neuronal plasticity

Autor: Caroline Biojone, Plinio C Casarotto, Cecilia Cannarozzo, Senem Merve Fred, Rosa Herrera-Rodríguez, Angelina Lesnikova, Mikko Voipio, Eero Castrén

Publikováno v: Biojone, C, C Casarotto, P, Cannarozzo, C, Fred, S M, Herrera-Rodríguez, R, Lesnikova, A, Voipio, M & Castrén, E 2023, ' nNOS-induced tyrosine nitration of TRKB impairs BDNF signaling and restrains neuronal plasticity ', Progress in Neurobiology, vol. 222, 102413 . https://doi.org/10.1016/j.pneurobio.2023.102413

Nitric oxide (NO) has been long recognized as an important modulator of neural plasticity, but characterization of the molecular mechanisms involved -specially the guanylyl cyclase-independent ones -has been challenging. There is evidence that NO cou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ffad7c44828901dce82f55878fc2a2
https://pure.au.dk/portal/da/publications/nnosinduced-tyrosine-nitration-of-trkb-impairs-bdnf-signaling-and-restrains-neuronal-plasticity(f37fdea9-2786-43b0-a72b-59b9b9f932c4).html

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SARS-CoV-2 infection of human neurons requires endosomal cell entry and can be blocked by inhibitors of host phosphoinositol-5 kinase

Autor: Pinja Kettunen, Angelina Lesnikova, Noora Räsänen, Ravi Ojha, Leena Palmunen, Markku Laakso, Šárka Lehtonen, Johanna Kuusisto, Olli Pietiläinen, Olli P. Vapalahti, Jari Kostinaho, Taisia Rolova, Giuseppe Balistreri

COVID-19 is a disease caused by coronavirus SARS-CoV-2. In addition to respiratory illness, COVID-19 patients exhibit neurological symptoms that can last from weeks to months (long COVID). It is unclear whether these neurological manifestations are d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2065ed9f50a7246f3afc87344b4364c
https://doi.org/10.1101/2022.09.14.508057

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Chondroitinase and Antidepressants Promote Plasticity by Releasing TRKB from Dephosphorylating Control of PTPσ in Parvalbumin Neurons

Autor: Hanna Antila, Plinio C. Casarotto, Eero Castrén, Frederike Winkel, Anna Steinzeig, Mikko Voipio, Caroline Biojone, Angelina Lesnikova, Senem Merve Fred, Juzoh Umemori

Publikováno v: The Journal of Neuroscience
BioRxiv
bioRxiv

Perineuronal nets (PNNs) are an extracellular matrix structure rich in chondroitin sulfate proteoglycans (CSPGs), which preferentially encase parvalbumin-containing (PV+) interneurons. PNNs restrict cortical network plasticity but the molecular mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22730c7be739c0adcc5e771235008558
http://europepmc.org/articles/PMC7880295

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Nitric oxide-induced tyrosine nitration of TrkB impairs BDNF signaling and restrains neuronal plasticity

Autor: Caroline Biojone, Plinio C Casarotto, Cecilia Cannarozzo, Senem Merve Fred, Rosa Herrera-Rodríguez, Angelina Lesnikova, Mikko Voipio, Eero Castrén

Nitric oxide has been long recognized as an important modulator of neural plasticity, but characterization of the molecular mechanisms involved - specially the guanylyl cyclase-independent ones - has been challenging. There is evidence that NO could

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::172b42dc46c19a54ea31594d56773aa5
https://doi.org/10.1101/2022.05.07.491033

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Anti-inflammatory treatment with FTY720 starting after onset of symptoms reverses synaptic and memory deficits in an AD mouse model

Autor: Hélène Marie, Eero Castrén, Ana R. Pereira, Plinio C. Casarotto, Georgia-Ioanna Kartalou, Thomas Endres, Angelina Lesnikova, Volkmar Lessmann, Paula A. Pousinha, Kurt Gottmann, Kevin Delanoe, Elke Edelmann

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2020, ⟨10.3390/ijms21238957⟩
bioRxiv

Therapeutical approaches providing effective medication for Alzheimer’s disease (AD) patients after disease onset are urgently needed. Repurposing FDA approved drugs like fingolimod (FTY720) for treatment of AD is a promising way to reduce the time

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5eeda3df9662b5a3ef1da9542c1866
https://hal.archives-ouvertes.fr/hal-03017159/file/Title_Anti-inflammatory_treatment_with_FTY720_star.pdf

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