Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Angelina E. Altshuler"'
1
Akademický článek
Transmural intestinal wall permeability in severe ischemia after enteral protease inhibition.
Autor: Angelina E Altshuler, Itze Lamadrid, Diana Li, Stephanie R Ma, Leena Kurre, Geert W Schmid-Schönbein, Alexander H Penn
Publikováno v: PLoS ONE, Vol 9, Iss 5, p e96655 (2014)
In intestinal ischemia, inflammatory mediators in the small intestine's lumen such as food byproducts, bacteria, and digestive enzymes leak into the peritoneal space, lymph, and circulation, but the mechanisms by which the intestinal wall permeabilit
Externí odkaz: https://doaj.org/article/fa3f9cafde954adf94059a5f303f6487
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2
Akademický článek
Protease activity increases in plasma, peritoneal fluid, and vital organs after hemorrhagic shock in rats.
Autor: Angelina E Altshuler, Alexander H Penn, Jessica A Yang, Ga-Ram Kim, Geert W Schmid-Schönbein
Publikováno v: PLoS ONE, Vol 7, Iss 3, p e32672 (2012)
Hemorrhagic shock (HS) is associated with high mortality. A severe decrease in blood pressure causes the intestine, a major site of digestive enzymes, to become permeable - possibly releasing those enzymes into the circulation and peritoneal space, w
Externí odkaz: https://doaj.org/article/d85202197dd349bb802ea2486daa7062
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3
Matrix Metalloproteinase-1-mediated Up-regulation of Vascular Endothelial Growth Factor-2 in Endothelial Cells
Autor: Erik B. Kistler, Geert W. Schmid-Schönbein, Helena Shaked, Elizabeth S. Pocock, Angelina E. Altshuler, Michael Karin, Tom Alsaigh, Rafi Mazor
Publikováno v: Journal of Biological Chemistry. 288:598-607
Matrix metalloproteinase-1 (MMP-1) is a collagenase that is highly active in extracellular matrix and vascular remodeling, angiogenesis, and tumor progression. Vascular endothelial growth factor receptor-2 (VEGFR2), the main receptor for VEGF-A, is e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e81368aa7ca20fc10d9d37d25671604
https://doi.org/10.1074/jbc.m112.417451
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4
Autodigestion: Proteolytic Degradation and Multiple Organ Failure in Shock
Autor: Angelina E. Altshuler, Geert W. Schmid-Schönbein, Erik B. Kistler
Publikováno v: Shock (Augusta, Ga.), vol 45, iss 5
Altshuler, AE; Kistler, EB; & Schmid-Schönbein, GW. (2016). Autodigestion: Proteolytic degradation and multiple organ failure in shock. Shock, 45(5), 483-489. doi: 10.1097/SHK.0000000000000544. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/8p57645r
© 2016 by the Shock Society. There is currently no effective treatment for multiorgan failure following shock other than supportive care. A better understanding of the pathogenesis of these sequelae to shock is required. The intestine plays a centra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c31eba76c599469bd4d9364239c6608
https://escholarship.org/uc/item/8p57645r
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5
Digested formula but not digested fresh human milk causes death of intestinal cells in vitro: implications for necrotizing enterocolitis
Autor: Angelina E. Altshuler, Sharon F. Taylor, James W. Small, Alexander H. Penn, Karen R. Dobkins, Geert W. Schmid-Schönbein
Publikováno v: Pediatric Research. 72:560-567
Premature infants fed formula are more likely to develop necrotizing enterocolitis (NEC) than those who are breastfed, but the mechanisms of intestinal necrosis in NEC and protection by breast milk are unknown. We hypothesized that after lipase diges
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db29faabdfaa8d0a74989c145604758
https://doi.org/10.1038/pr.2012.125
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6
Effect of digestion and storage of human milk on free fatty acid concentration and cytotoxicity
Autor: Karen R. Dobkins, Angelina E. Altshuler, James W. Small, Alexander H. Penn, Geert W. Schmid-Schönbein, Sharon F. Taylor
Publikováno v: Journal of pediatric gastroenterology and nutrition, vol 59, iss 3
Objectives Fat is digested in the intestine into free fatty acids (FFAs), which are detergents and therefore toxic to cells at micromolar concentration. The mucosal barrier protects cells in the adult intestine, but this barrier may not be fully deve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9810b5822bab1360e4a8f1b437c95022
https://escholarship.org/uc/item/9js3p2bm
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7
Transmural intestinal wall permeability in severe ischemia after enteral protease inhibition
Autor: Itze Lamadrid, Angelina E. Altshuler, Diana Li, Leena Kurre, Geert W. Schmid-Schönbein, Stephanie R. Ma, Alexander H. Penn
Publikováno v: PloS one, vol 9, iss 5
PLoS ONE, Vol 9, Iss 5, p e96655 (2014)
PLoS ONE
In intestinal ischemia, inflammatory mediators in the small intestine's lumen such as food byproducts, bacteria, and digestive enzymes leak into the peritoneal space, lymph, and circulation, but the mechanisms by which the intestinal wall permeabilit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::941769dabba55422b1046208b6bd51de
https://escholarship.org/uc/item/417437qr
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8
Removal of luminal content protects the small intestine during hemorrhagic shock but is not sufficient to prevent lung injury
Autor: Geert W. Schmid-Schönbein, Angelina E. Altshuler, Alexander H. Penn, Michael Richter, Augusta E. Modestino, Michael J. Heller
Publikováno v: Physiological Reports
Physiological reports, vol 1, iss 5
The small intestine plays a key role in the pathogenesis of multiple organ failure following circulatory shock. Current results show that reduced perfusion of the small intestine compromises the mucosal epithelial barrier, and the intestinal contents
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bab010846b6ac25c133a682653b9b85
https://pubmed.ncbi.nlm.nih.gov/24303180
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