Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Angelina Bisconte"'
Autor:
Timothy D. Owens, Ken A. Brameld, Erik J. Verner, Tony Ton, Xiaoyan Li, Jiang Zhu, Mohammad R. Masjedizadeh, J. Michael Bradshaw, Ronald J. Hill, Danny Tam, Angelina Bisconte, Eun Ok Kim, Michelle Francesco, Yan Xing, Jin Shu, Dane Karr, Jacob LaStant, David Finkle, Natalie Loewenstein, Helena Haberstock-Debic, Michael J. Taylor, Philip Nunn, Claire L. Langrish, David M. Goldstein
Publikováno v:
Journal of medicinal chemistry. 65(7)
Bruton's tyrosine kinase (BTK), a Tec family tyrosine kinase, is critical in immune pathways as an essential intracellular signaling element, participating in both adaptive and immune responses. Currently approved BTK inhibitors are irreversible cova
Autor:
Aaron E. Lisberg, Jonathan W. Goldman, Balazs Halmos, Gregory James Gerstner, Neil Morganstein, Charles Michael Farber, Kyoung A Viola Lee, Lydia ML Holtgrewe, Casey Codd, Angelina Bisconte, Theodore Foss, Surya Vangala, Megan Parsi, Andres A. Gutierrez, Suresh S. Ramalingam
Publikováno v:
Journal of Clinical Oncology. 40:9042-9042
9042 Background: The administration of a lung cancer-specific immunotherapy with 22 tumor-associated antigens (ADXS-503, A503), has been evaluated as an add-on therapy for patients (pts) with metastatic non-small-cell lung cancer (NSCLC) who have pro
Autor:
J. Michael Bradshaw, Angelina Bisconte, Ken A. Brameld, Claire L. Langrish, Timothy D. Owens, David Michael Goldstein, Catherine A. Outerbridge, Philip A. Nunn, Ronald J. Hill, Jacob LaStant, Stephen D. White, Jin Shu, Michelle Francesco, Yan Xing
Publikováno v:
J Immunol
Journal of immunology (Baltimore, Md. : 1950), vol 206, iss 7
Journal of immunology (Baltimore, Md. : 1950), vol 206, iss 7
Bruton tyrosine kinase (BTK) is expressed in B cells and innate immune cells, acting as an essential signaling element in multiple immune cell pathways. Selective BTK inhibition has the potential to target multiple immune-mediated disease pathways. R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34ff3a7e358b3f78ad8297b0f039949
https://europepmc.org/articles/PMC7980532/
https://europepmc.org/articles/PMC7980532/
Autor:
Petra Bizikova, Steven G. Gourlay, Catherine A. Outerbridge, Philip A. Nunn, Ronald J. Hill, Dori L. Borjesson, Stephen D. White, Tyler J.M. Jordan, Michelle Francesco, Angelina Bisconte, Carolyn B. Emery, Dedee F. Murrell, Elizabeth C. Goodale, Mohammad Masjedizadeh
Publikováno v:
Veterinary dermatologyReferences. 31(5)
Bruton's tyrosine kinase (BTK) is important in B-cell signalling. Efficacy has been reported for BTK inhibitors (BTKi) in human autoimmune diseases. Canine pemphigus foliaceus (cPF) is one of the most common canine autoimmune skin diseases.To determi
Autor:
Andreas Margraf, Ronald J. Hill, Angelina Bisconte, Claire L Langrish, Benedito Eduardo Correia, J. Michael Bradshaw, Clifford A. Lowell, Alexander Zarbock, Stephanie Volmering, Jan M. Herter
Publikováno v:
British Journal of Pharmacology. 175:429-439
Background and purpose Following inflammatory stimuli, neutrophils are recruited to sites of inflammation and exert effector functions that often have deleterious effects on tissue integrity, which can lead to organ failure. Bruton's tyrosine kinase
Autor:
Venkat Mohanram, Andres A. Gutierrez, Suresh S. Ramalingam, Jonathan W. Goldman, Deborah Phippard, Megan Parsi, Gregory James Gerstner, Victor Kabala, Balazs Halmos, Missak Haigentz, Darren Davis, Surya Vangala, Dinesh Simkhada, Cristiane Metran, Thomas E. Stinchcombe, Natalya Belkina, Angelina Bisconte
Publikováno v:
Cancer Research. 81:1671-1671
Precision for Medicine (Precision) developed and qualified two 17 color flow immunophenotyping assays to be used as pharmacodynamic biomarkers for Advaxis clinical studies in patients with Metastatic Non-Small Cell Lung Cancer treated with ADXS-503 a
Autor:
Dori L. Borjesson, Philip A. Nunn, Katarina E. Varjonen, Petra Bizikova, Mohammad Masjedizadeh, Catherine A. Outerbridge, Elizabeth C. Goodale, Dedee F. Murrell, Stephen D. White, Angelina Bisconte, Ronald J. Hill, Michelle Francesco, Steven G. Gourlay
Publikováno v:
Veterinary Dermatology. 31:291
Bruton's tyrosine kinase (BTK) is important in B-cell signalling. Efficacy has been reported for BTK inhibitors (BTKi) in human autoimmune diseases. Canine pemphigus foliaceus (cPF) is the most common canine autoimmune skin disease.To determine the s
Autor:
Timothy D. Owens, Kelsey Thornton, Ethan Strattan, Anjali Mishra, Jens Oliver Funk, Yiming Zhong, Erik Verner, Ronald J. Hill, Angelina Bisconte, Jonathan P. Butchar, Pierluigi Porcu, Amy J. Johnson, Jason A. Dubovsky, Li Ren, Shuai Dong, Ken A. Brameld, J. Michael Bradshaw
Publikováno v:
Journal of Biological Chemistry. 290:5960-5978
Interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK or TXK) are essential mediators of intracellular signaling in both normal and neoplastic T-cells and natural killer (NK) cells. Thus, ITK and RLK inhibitors have therapeut
Autor:
Bryan K. Chan, Cristina Lewis, Steve Price, Brian Safina, Robert Heald, Zachary Kevin Sweeney, Jodie Pang, Karin Reif, Georgette Castanedo, Jun Li, Daniel P. Sutherlin, Michael Flagella, Eileen Mary Seward, Jeremy Murray, Jim Nonomiya, Laurent Salphati, Angelina Bisconte, Binqing Wei, Diane E. Carrera
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23(17):4953-4959
In an effort to identify potent and isoform selective inhibitors of PI3Kδ, GNE-293 (34) was identified. Inhibitor 2 was found to induce micronuclei formation in both the MNT and HCA in vitro assays. Compounds testing negative for genotoxicity were s
Autor:
Laurent Salphati, Stewart J. Baker, Steve Price, Jim Nonomiya, Matthew C. Lucas, Timothy Hancox, David Knowles, Bohdan Waszkowycz, Neil Anthony Pegg, David Chantry, Bryan K. Chan, Paul Blaney, Anthony Brown, Steven T. Staben, Jodie Pang, Paul Depledge, Rama K. Kondru, Mark Ultsch, Paul Goldsmith, Karin Reif, Angelina Bisconte, Cristina Lewis, Eileen Mary Seward, Jeremy Murray, Brian Safina, Daniel P. Sutherlin, Zachary Kevin Sweeney, Georgette Castanedo, David Michael Goldstein, Jasmit Kaur, Sukhjit Sohal, Binqing Wei, John Lesnick, Stephen J. Shuttleworth, Alan Nadin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4296-4302
A potent inhibitor of PI3Kδ that is ⩾200 fold selective for the remaining three Class I PI3K isoforms and additional kinases is described. The hypothesis for selectivity is illustrated through structure activity relationships and crystal structure