CD3 aptamers promote expansion and persistence of tumor-reactive T cells for adoptive T cell therapy in cancer

Autor: Ashwathi Puravankara Menon, Helena Villanueva, Daniel Meraviglia-Crivelli, Hisse M. van Santen, Joschka Hellmeier, Angelina Zheleva, Francesca Nonateli, Timo Peters, Tassilo L.A. Wachsmann, Mercedes Hernandez-Rueda, Johannes B. Huppa, Gerhard J. Schütz, Eva Sevcsik, Beatriz Moreno, Fernando Pastor

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102198- (2024)

The CD3/T cell receptor (TCR) complex is responsible for antigen-specific pathogen recognition by T cells, and initiates the signaling cascade necessary for activation of effector functions. CD3 agonistic antibodies are commonly used to expand T lymp

Externí odkaz: https://doaj.org/article/6c3ef753dfa94901b0ef2480454cb96e

A pan-tumor-siRNA aptamer chimera to block nonsense-mediated mRNA decay inflames and suppresses tumor progression

Autor: Daniel Meraviglia-Crivelli, Helena Villanueva, Ashwathi Puravankara Menon, Angelina Zheleva, Beatriz Moreno, María Villalba-Esparza, Fernando Pastor

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 413-425 (2022)

Immune-checkpoint blockade (ICB) therapy has changed the clinical outcome of many types of aggressive tumors, but there still remain many cancer patients that do not respond to these treatments. There is an unmet need to develop a feasible clinical t

Externí odkaz: https://doaj.org/article/12638e60bd4c449d8adab68bb1e7c48d

Reduction of mRNA export unmasks different tissue sensitivities to low mRNA levels during Caenorhabditis elegans development.

Autor: Angelina Zheleva, Eva Gómez-Orte, Beatriz Sáenz-Narciso, Begoña Ezcurra, Henok Kassahun, María de Toro, Antonio Miranda-Vizuete, Ralf Schnabel, Hilde Nilsen, Juan Cabello

Publikováno v: PLoS Genetics, Vol 15, Iss 9, p e1008338 (2019)

Animal development requires the execution of specific transcriptional programs in different sets of cells to build tissues and functional organs. Transcripts are exported from the nucleus to the cytoplasm where they are translated into proteins that,

Externí odkaz: https://doaj.org/article/e149ea064545429a9d55007df65aa98e

THSC/TREX-2 deficiency causes replication stress and genome instability in Caenorhabditis elegans

Autor: Andrés Aguilera, Nuria Fernández-Fernández, María L. García-Rubio, Peter Askjaer, Lola P. Camino, Angelina Zheleva, Tatiana García-Muse

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Transcription is an essential process of DNA metabolism, yet it makes DNA more susceptible to DNA damage. THSC/TREX-2 is a conserved eukaryotic protein complex with a key role in mRNP biogenesis and maturation that prevents genome instability. One so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e765b9c8ce35ab5b14bb97f29599e7b5
http://hdl.handle.net/10261/260074

Effect of the diet type and temperature on theC. eleganstranscriptome

Autor: María de Toro, Begoña Ezcurra, Juan-Félix San-Juan, Eric Cornes, Angelina Zheleva, Eva Gómez-Orte, Adolfo Sánchez-Blanco, Beatriz Sáenz-Narciso, Rosario López, María Íñiguez, Juan Cabello, Begoña Sacristán, Julián Cerón

Publikováno v: RIUR: Repositorio Institucional de la Universidad de La Rioja
Universidad de La Rioja (UR)
RIUR. Repositorio Institucional de la Universidad de La Rioja
instname

The transcriptomes of model organisms have been defined under specific laboratory growth conditions. The standard protocol for Caenorhabditis elegans growth and maintenance is 20°C on an Escherichia coli diet. Temperatures ranging from 15°C to 25°

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a59733b6b9c2199ebb4f408d6c3b51d
https://doi.org/10.18632/oncotarget.23563