Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Angeliki Thanasopoulou"'
Autor:
James N. Fisher, Angeliki Thanasopoulou, Sabine Juge, Alexandar Tzankov, Frederik O. Bagger, Max A. Mendez, Antoine H.F.M. Peters, Juerg Schwaller
Publikováno v:
Haematologica, Vol 105, Iss 7 (2020)
Inv(11)(p15q23), found in myelodysplastic syndromes and acute myeloid leukemia, leads to expression of a fusion protein consisting of the N-terminal of nucleoporin 98 (NUP98) and the majority of the lysine methyltransferase 2A (KMT2A). To explore the
Externí odkaz:
https://doaj.org/article/4bf9953a211546ffb8dcb68244d2165b
Publikováno v:
Haematologica, Vol 99, Iss 9 (2014)
The NUP98-NSD1 fusion, product of the t(5;11)(q35;p15.5) chromosomal translocation, is one of the most prevalent genetic alterations in cytogenetically normal pediatric acute myeloid leukemias and is associated with poor prognosis. Co-existence of an
Externí odkaz:
https://doaj.org/article/346e848dfda64b9191d07fcfaf88f451
Autor:
Angeliki Thanasopoulou, Dimitrios J Stravopodis, Konstantinos S Dimas, Juerg Schwaller, Ema Anastasiadou
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31007 (2012)
In most cancers harboring Ccdc6 gene rearrangements, like papillary thyroid tumors or myeloproliferative disorders, the product of the normal allele is supposed to be functionally impaired or absent. To address the consequence of the loss of CCDC6 ex
Externí odkaz:
https://doaj.org/article/7b3e5a2e594c416390d5cf13f0f483a5
Autor:
Stefan Knapp, Jürg Schwaller, Rab Prinjha, Tony Kouzarides, Nicholas B. La Thangue, Marjeta Urh, Danette L. Daniels, Duncan Hay, Susanne Müller, Sharlene Velichko, Alison O'Mahony, Paul E. Brennan, Chas Bountra, Matteo L. Vecellio, Simon Taylor, Philip Jeffrey, Dave Lugo, Kevin Lee, Nigel Parr, Umesh Kumar, Samuel Robson, Andrew Bannister, Ka Hing Che, Christopher Wells, Clarence Yapp, Panagis Filippakopoulos, Anthony Tumber, Martin Philpott, Sarah Martin, Octovia Monteiro, Heidi Olzscha, Julia Meier, Katherine Jones, Katharina Leonards, Angeliki Thanasopoulou, Oleg Fedorov, Sarah Picaud
Description of additional methods and procedures used in the study. Also includes Supplemental References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57235f2b6dacb19e5e6c1bbf5652d40c
https://doi.org/10.1158/0008-5472.22406324
https://doi.org/10.1158/0008-5472.22406324
Autor:
Stefan Knapp, Jürg Schwaller, Rab Prinjha, Tony Kouzarides, Nicholas B. La Thangue, Marjeta Urh, Danette L. Daniels, Duncan Hay, Susanne Müller, Sharlene Velichko, Alison O'Mahony, Paul E. Brennan, Chas Bountra, Matteo L. Vecellio, Simon Taylor, Philip Jeffrey, Dave Lugo, Kevin Lee, Nigel Parr, Umesh Kumar, Samuel Robson, Andrew Bannister, Ka Hing Che, Christopher Wells, Clarence Yapp, Panagis Filippakopoulos, Anthony Tumber, Martin Philpott, Sarah Martin, Octovia Monteiro, Heidi Olzscha, Julia Meier, Katherine Jones, Katharina Leonards, Angeliki Thanasopoulou, Oleg Fedorov, Sarah Picaud
The histone acetyltransferases CBP/p300 are involved in recurrent leukemia-associated chromosomal translocations and are key regulators of cell growth. Therefore, efforts to generate inhibitors of CBP/p300 are of clinical value. We developed a specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40435e054abe8c3438258da01486a385
https://doi.org/10.1158/0008-5472.c.6507044
https://doi.org/10.1158/0008-5472.c.6507044
Autor:
Stefan Knapp, Jürg Schwaller, Rab Prinjha, Tony Kouzarides, Nicholas B. La Thangue, Marjeta Urh, Danette L. Daniels, Duncan Hay, Susanne Müller, Sharlene Velichko, Alison O'Mahony, Paul E. Brennan, Chas Bountra, Matteo L. Vecellio, Simon Taylor, Philip Jeffrey, Dave Lugo, Kevin Lee, Nigel Parr, Umesh Kumar, Samuel Robson, Andrew Bannister, Ka Hing Che, Christopher Wells, Clarence Yapp, Panagis Filippakopoulos, Anthony Tumber, Martin Philpott, Sarah Martin, Octovia Monteiro, Heidi Olzscha, Julia Meier, Katherine Jones, Katharina Leonards, Angeliki Thanasopoulou, Oleg Fedorov, Sarah Picaud
BLI evaluation of I-CBP112 selectivity (S1); BioMAP data for I-CBP112 (S2); Effects on MLL-AF9 and NUP98-HOXA9 (S3); Immunophenotype of injected MLL-AF9 cells (S4); Cell survival data (S5); Synergy with JQ1 and doxorubicin (S6).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7179d3022dddf0f23baaefb469c32d18
https://doi.org/10.1158/0008-5472.22406327.v1
https://doi.org/10.1158/0008-5472.22406327.v1
Autor:
Stefan Knapp, Jürg Schwaller, Rab Prinjha, Tony Kouzarides, Nicholas B. La Thangue, Marjeta Urh, Danette L. Daniels, Duncan Hay, Susanne Müller, Sharlene Velichko, Alison O'Mahony, Paul E. Brennan, Chas Bountra, Matteo L. Vecellio, Simon Taylor, Philip Jeffrey, Dave Lugo, Kevin Lee, Nigel Parr, Umesh Kumar, Samuel Robson, Andrew Bannister, Ka Hing Che, Christopher Wells, Clarence Yapp, Panagis Filippakopoulos, Anthony Tumber, Martin Philpott, Sarah Martin, Octovia Monteiro, Heidi Olzscha, Julia Meier, Katherine Jones, Katharina Leonards, Angeliki Thanasopoulou, Oleg Fedorov, Sarah Picaud
I-CBP112 ΔTm data for bromodomains (S1); I-CBP112 ITC data (S2); Selectivity screening data outside BRD family (S3); ITC data (S4); Data collection and refinement statistics (S5); I-CBP112 deregulated genes 3d KASUMI-1 (S6); I-CBP112 deregulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1968754395c665786341968851738032
https://doi.org/10.1158/0008-5472.22406321
https://doi.org/10.1158/0008-5472.22406321
Autor:
Christopher Lane, Szofia Bullain, Angeliki Thanasopoulou, Paul Delmar, Mercè Boada, Timo Grim-Mer, Diana Kerwin, Monika Baudler-Klein, Geoffrey A Kerchner, Rachelle S Doody
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 93:e2.250
Gantenerumab is a fully human anti-amyloid beta (Aβ) monoclonal immunoglobulin G1 antibody in devel- opment for the treatment of Alzheimer’s disease (AD). Two ongoing multicentre, randomised, double-blind, placebo-controlled, Phase III studies, GR
Autor:
Sabine Juge, Alexandar Tzankov, Antoine H.F.M. Peters, Angeliki Thanasopoulou, Juerg Schwaller, James N. Fisher, Max A. Mendez, Frederik Otzen Bagger
Publikováno v:
Haematologica
Inv(11)(p15q23), found in myelodysplastic syndromes and acute myeloid leukemia, leads to expression of a fusion protein consisting of the N-terminal of nucleoporin 98 (NUP98) and the majority of the lysine methyltransferase 2A (KMT2A). To explore the
Autor:
Komal Kumar Javarappa, Caroline A. Heckman, Ashwini Kumar, Samuli Eldfors, Mika Kontro, Angeliki Thanasopoulou, Muntasir Mamun Majumder, Kimmo Porkka, Jarno Kivioja, Bhagwan Yadav, Juerg Schwaller
Publikováno v:
Leukemia. 33:1360-1372
Acute myeloid leukemia (AML) with co-occurring NUP98-NSD1 and FLT3-ITD is associated with unfavorable prognosis and represents a particularly challenging treatment group. To identify novel effective therapies for this AML subtype, we screened patient