Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Angeliki Kourounakis"'
Publikováno v:
Bioengineering, Vol 9, Iss 12, p 800 (2022)
Even though non-steroidal anti-inflammatory drugs are the most effective treatment for inflammatory conditions, they have been linked to negative side effects. A promising approach to mitigating potential risks, is the development of new compounds ab
Externí odkaz:
https://doaj.org/article/2627501c38344ce59605ec25f85c1749
Publikováno v:
Molecules, Vol 26, Iss 16, p 4928 (2021)
Oxidative stress and inflammation are two conditions that coexist in many multifactorial diseases such as atherosclerosis and neurodegeneration. Thus, the design of multifunctional compounds that can concurrently tackle two or more therapeutic target
Externí odkaz:
https://doaj.org/article/d4293e18c4a34f1189239d850438793e
Publikováno v:
Current Drug Metabolism. 6:481-485
The effect on hepatic drug metabolising enzymes was evaluated for three representative structures (1, 2 and 3) that were selected from a series of substituted oxazine derivatives designed to possess particular pharmacological properties such as analg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::630a30c4dac7d3c363a60517dac6e6d8
https://doi.org/10.2174/138920005774330648
https://doi.org/10.2174/138920005774330648
Publikováno v:
Il Farmaco. 56:67-70
Allosteric modulation of G protein-coupled receptors is a relatively novel and unexplored pharmacological concept that may lead to more selective and more ‘natural’ drugs for these receptors. In particular, allosteric enhancers may serve as tools
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53210b8f22c54345b42a108ef276c8bd
https://doi.org/10.1016/s0014-827x(01)01015-1
https://doi.org/10.1016/s0014-827x(01)01015-1
Publikováno v:
Biochemical Pharmacology. 61:137-144
The 2-amino-benzoylthiophene derivative PD81,723 [(2-amino-4,5-dimethyl-trienyl)[3-(trifluoromethyl) phenyl]methanone] has been shown to allosterically enhance agonist binding and function at the adenosine A 1 receptor. The aim of the present study w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecf7ebed80f66d56c5ae8196773fa61c
https://doi.org/10.1016/s0006-2952(00)00536-0
https://doi.org/10.1016/s0006-2952(00)00536-0
Publikováno v:
Drug Development Research. 49:227-237
Novel 2-amino-3-benzoylthiophene derivatives, with variable substitution on the thiophene as well as benzoyl ring, were synthesized and evaluated both as allosteric enhancers of agonist binding to the rat adenosine A1 receptor, and as antagonists on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b81078eaa54eb57270c0a0323d8864e
https://doi.org/10.1002/1098-2299(200004)49:4<227::aid-ddr1>3.0.co
https://doi.org/10.1002/1098-2299(200004)49:4<227::aid-ddr1>3.0.co
Publikováno v:
International Journal of Pharmaceutics. 141:239-250
A novel brain-targeted catechol derivative was designed for the potential in vivo induction of nerve growth factor (NGF) biosynthesis within the central nervous system (CNS) after its peripheral administration. The dihydropyridine-pyridinium salt moi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::727cd6ad9c467fca8231a3f58bab7c10
https://doi.org/10.1016/0378-5173(96)04642-x
https://doi.org/10.1016/0378-5173(96)04642-x
Autor:
Angeliki Kourounakis, Nicholas Bodor
Publikováno v:
Pharmaceutical Research. 12:1199-1204
Purpose. Although many catechol derivatives are potent stimulators of Nerve Growth Factor synthesis in L-M cells, not much is known about their mechanism of action. In order to obtain a Quantitative Structure Activity Relationship (QSAR), AM1 quantum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b74e2be018680e4953d5e75c6db2def
https://doi.org/10.1023/a:1016455728763
https://doi.org/10.1023/a:1016455728763
Publikováno v:
ChemInform. 32
Allosteric modulation of G protein-coupled receptors is a relatively novel and unexplored pharmacological concept that may lead to more selective and more ‘natural’ drugs for these receptors. In particular, allosteric enhancers may serve as tools
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0068a5b663e2989f600ba897e9c69531
https://doi.org/10.1002/chin.200128295
https://doi.org/10.1002/chin.200128295
Publikováno v:
Drug Discovery Strategies and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccde6bb36f75381dc350d8727ee89ae3
https://doi.org/10.1201/9780203913277.ch8
https://doi.org/10.1201/9780203913277.ch8
