Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Angelika Walzl"'
Autor:
Nina Kramer, Markus Hengstschläger, Angelika Walzl, Helmut Dolznig, Martin Scherzer, Christine Unger
Publikováno v:
Advanced Drug Delivery Reviews. :50-67
Anti-cancer drug development is inefficient, mostly due to lack of efficacy in human patients. The high fail rate is partly due to the lack of predictive models or the inadequate use of existing preclinical test systems. However, progress has been ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faec6c9d039e414755155ee8fc0f47d6
https://doi.org/10.1016/j.addr.2014.10.015
https://doi.org/10.1016/j.addr.2014.10.015
Autor:
Markus Hengstschläger, Christine Unger, Dagmar Schwanzer-Pfeiffer, Martin Scherzer, Helmut Dolznig, Nina Kramer, Angelika Walzl, Daniela Unterleuthner
Publikováno v:
SLAS Discovery. 19:1047-1059
Spheroid-based cellular screening approaches represent a highly physiologic experimental setup to identify novel anticancer drugs and an innovative preclinical model to reduce the high failure rate of anticancer compounds in clinical trials. The resa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779840c0f6333ae8d13c6c13da94935d
https://doi.org/10.1177/1087057114532352
https://doi.org/10.1177/1087057114532352
Autor:
Nina Kramer, Christine Unger, Margit Rosner, Angelika Walzl, Helmut Dolznig, Markus Hengstschläger, Georg Krupitza
Publikováno v:
Mutation Research/Reviews in Mutation Research. 752:10-24
Determining the migratory and invasive capacity of tumor and stromal cells and clarifying the underlying mechanisms is most relevant for novel strategies in cancer diagnosis, prognosis, drug development and treatment. Here we shortly summarize the di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208b3e08f8fac1ea3f7baed115ccfc5b
https://doi.org/10.1016/j.mrrev.2012.08.001
https://doi.org/10.1016/j.mrrev.2012.08.001
Autor:
Angelika Walzl, Stefanie Walter, Nina Kramer, Mira Stadler, Martin Scherzer, Christine Unger, Helmut Dolznig, Markus Hengstschläger
The development of novel anticancer drugs is far from being efficient, mostly due to lack of efficacy in human patients. The 95% attrition rate in the clinic is predominantly owing to the shortage of predictive preclinical models. However, during rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77eec7823fad7950d8f67d986b66d1ff
https://doi.org/10.1016/b978-0-12-802208-5.00004-7
https://doi.org/10.1016/b978-0-12-802208-5.00004-7
Autor:
Nina Kramer, Margit Rosner, Pilar Garin-Chesa, Angelika Walzl, Helmut Dolznig, Markus Hengstschläger
Publikováno v:
Drug Discovery Today: Disease Models. 8:113-119
Metastasis, which is linked to the invasive properties acquired by the primary tumor during cancer progression, is the major life-threatening event in cancer patients. There is increasing evidence that the tumor stroma is involved in the infiltrative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0682ee1a6f1dae1865e24401b2566edc
https://doi.org/10.1016/j.ddmod.2011.06.003
https://doi.org/10.1016/j.ddmod.2011.06.003
Autor:
Georg Krupitza, Markus Hengstschläger, Stefanie Walter, Mira Stadler, Helmut Dolznig, Angelika Walzl, Nina Kramer, Christine Unger, Daniela Unterleuthner, Martin Scherzer
Publikováno v:
Seminars in cancer biology. 35
Solid cancers are not simple accumulations of malignant tumor cells but rather represent complex organ-like structures. Despite a more chaotic general appearance as compared to the highly organized setup of healthy tissues, cancers still show highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a937bc4c579dc1663cbaeeed72b350c4
https://pubmed.ncbi.nlm.nih.gov/26320002
https://pubmed.ncbi.nlm.nih.gov/26320002
Autor:
Georg Krupitza, Nicole Huttary, Stefan Brenner, Helmut Dolznig, Angelika Walzl, Silvio Holzner, Robert M. Mader, Maria Kalipciyan, Sigurd Krieger, Walter Jäger, Daniel Senfter, Anna Staribacher
Publikováno v:
Human Molecular Genetics.
Invasive colorectal cancer is associated with poor prognosis requiring treatment with systemic chemotherapies usually including 5-fluorouracil. A consequence of prolonged treatment is the acquisition of resistance eventually resulting in the recurren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f1fb1e52848378cf3d5ddfc7414788
https://doi.org/10.1093/hmg/ddv113
https://doi.org/10.1093/hmg/ddv113