Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Angelika Meyer"'
Autor:
Joanna Brzeszczyńska, Angelika Meyer, Robin McGregor, Alain Schilb, Simone Degen, Valentina Tadini, Neil Johns, Ramon Langen, Annemie Schols, David J. Glass, Ronenn Roubenoff, James A. Ross, Kenneth C.H. Fearon, Carolyn A. Greig, Carsten Jacobi
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 1, Pp 93-105 (2018)
Abstract Background Sarcopenia is defined as the age‐related loss of skeletal muscle mass and function. While all humans lose muscle with age, 2–5% of elderly adults develop functional consequences (disabilities). The aim of this study was to inv
Externí odkaz:
https://doaj.org/article/c09f7a587c5642489648c9ba03775860
Autor:
Michael Bidinosti, Erwin Hermes, Claudia Merkl, James Fessenden, Ulrike Naumann, Alexandra Vissieres, Joanna Mitchelmore, Elizaveta M. Solovyeva, Fabrizio C. Serluca, Sebastian Hoersch, Angelika Meyer, Tania Poetsch, Marie Ronco, Stephan Utzinger, Hans Voshol, Erik Ahrné
Dysregulated mRNA splicing is involved in the pathogenesis of many diseases including cancer, neurodegenerative diseases, and muscular dystrophies such as myotonic dystrophy type 1 (DM1). Comprehensive assessment of dysregulated splicing on the trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72481f6042e5bb5c352d2121417e7b3b
https://doi.org/10.1101/2021.05.15.443842
https://doi.org/10.1101/2021.05.15.443842
Autor:
Elizaveta M. Solovyeva, Chikwendu Ibebunjo, Fabrizio C. Serluca, Yunyu Zhang, Stephan Utzinger, Ulrike Naumann, Sabrina Demirci, Martin Rausch, Angelika Meyer, Berndt Oberhauser, John K. Eash, Sebastian Hoersch, Frederique Black, Andrew Dunbar
Publikováno v:
Mechanisms of ageing and development. 197
Progressive loss of muscle mass and function due to muscle fiber atrophy and loss in the elderly and chronically ill is now defined as sarcopenia. It is a major contributor to loss of independence, disability, need of long-term care as well as overal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b096dd425b5715e463040f47219527
https://pubmed.ncbi.nlm.nih.gov/34019916
https://pubmed.ncbi.nlm.nih.gov/34019916
Autor:
Reginald Valdez, Lin Fan, Yanqun Wang, Jiang Zhu, Sharon X. Wang, David J. Glass, Tea Shavlakadze, Joan Mannick, Weihua Zhou, Angelika Meyer, Oleg Iartchouk, Marc A. Egerman, Lloyd B. Klickstein, Bret Morin
Publikováno v:
The Journals of Gerontology: Series A. 73:845-852
Rapalogs, inhibitors of mTORC1 (mammalian target of rapamycin complex 1), increase life span and delay age-related phenotypes in many species. However, the molecular mechanisms have not been fully elucidated. We determined gene expression changes com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b9e8759d9c6b8b4a91296c055db3e1
https://doi.org/10.1093/gerona/glx249
https://doi.org/10.1093/gerona/glx249
Autor:
Joanna Brzeszczynska, Neil Johns, Simone Degen, Alain Schilb, Ronenn Roubenoff, Carsten Jacobi, Kenneth C. H. Fearon, Angelika Meyer, Carolyn A. Greig, James A. Ross, Robin A. McGregor, David J. Glass, Ramon C. J. Langen, Annemie M. W. J. Schols, Valentina Tadini
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle. 9:93-105
BACKGROUND Sarcopenia is defined as the age-related loss of skeletal muscle mass and function. While all humans lose muscle with age, 2-5% of elderly adults develop functional consequences (disabilities). The aim of this study was to investigate musc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38a3ec35d0c1faeef3fa624bef7c1464
https://doi.org/10.1002/jcsm.12252
https://doi.org/10.1002/jcsm.12252
Autor:
Adelaide Fernandes, Maria Alexandra Brito, Soner Dogan, Martin Hrabé de Angelis, Ronald van Os, Anne-Ulrike Trendelenburg, Sophia Athanasopoulou, Angelika Meyer, Johannes Grillari, Giovambattista Pani, Pärt Peterson, Juan Antonio Aguilar-Pimentel, Ana L. Cardoso, Markus Schosserer, Saida Ortolano, Efstathios S. Gonos, Joana R. Guedes, Bilge Guvenc Tuna
Publikováno v:
Ageing Research Reviews
Ageing Res. Rev. 47, 214-277 (2018)
Ageing Res. Rev. 47, 214-277 (2018)
Objective: Use of the frailty index to measure an accumulation of deficits has been proven a valuable method for identifying elderly people at risk for increased vulnerability, disease, injury, and mortality. However, complementary molecular frailty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8a136e6a14f864be429336ca1e7e60
http://hdl.handle.net/10807/130553
http://hdl.handle.net/10807/130553
Autor:
Joseph P. Boyle, Daisy Rohner, Anne Ulrike Trendelenburg, Angelika Meyer, Shinji Hatakeyama, David J. Glass
Publikováno v:
American Journal of Physiology-Cell Physiology. 296:C1258-C1270
Myostatin is a negative regulator of skeletal muscle size, previously shown to inhibit muscle cell differentiation. Myostatin requires both Smad2 and Smad3 downstream of the activin receptor II (ActRII)/activin receptor-like kinase (ALK) receptor com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7642733559affe50727fb7255a0b04fa
https://doi.org/10.1152/ajpcell.00105.2009
https://doi.org/10.1152/ajpcell.00105.2009
Autor:
Marc A. Egerman, Tea Shavlakadze, Estelle Lach-Trifilieff, Carolyn Mallozzi, Ieuan Clay, Lori L. Jennings, Jason A. Gilbert, Anne-Ulrike Trendelenburg, David J. Glass, Angelika Meyer, Andrew S. Brack, Susanne E. Swalley, Samuel M. Cadena, Shenglin Ma, Carsten Jacobi, Gaëlle Laurent, Hallie N. Nelson, Sophie Brachat
Publikováno v:
Cell metabolism. 22(1)
SummaryAge-related frailty may be due to decreased skeletal muscle regeneration. The role of TGF-β molecules myostatin and GDF11 in regeneration is unclear. Recent studies showed an age-related decrease in GDF11 and that GDF11 treatment improves mus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe3a0749a492161746a65bd5f4b4475
https://pubmed.ncbi.nlm.nih.gov/26003784
https://pubmed.ncbi.nlm.nih.gov/26003784
Publikováno v:
British Journal of Pharmacology. 145:1153-1159
The muscarinic heteroreceptors modulating noradrenaline release in atria, urinary bladder and vas deferens were previously studied in mice in which the M(2) or the M(4) muscarinic receptor genes had been disrupted. These experiments showed that these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2e23f8d75a64747a6061b3141f9f004
https://doi.org/10.1038/sj.bjp.0706297
https://doi.org/10.1038/sj.bjp.0706297
Publikováno v:
British Journal of Pharmacology. 138:1389-1402
In mouse atria, angiotensin II and bradykinin lose much or all of their noradrenaline release-enhancing effect when presynaptic α2-autoinhibition does not operate either because of stimulation with very brief pulse trains or because of treatment wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe015d1d17bb769a50babde53d9ff833
https://doi.org/10.1038/sj.bjp.0705223
https://doi.org/10.1038/sj.bjp.0705223