Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Angelika Horn"'
Autor:
Jérôme Avouac, Katrin Palumbo, Michal Tomcik, Britta Maurer, Georg Schett, Yannick Allanore, Oliver Distler, Jörg H W Distler, Anika Sadowski, Clara Dees, Pawel Zerr, Angelika Horn, Shunichi Shiozawa, Christian Beyer, Holm Schneider, Alfiya Akhmetshina
Publikováno v:
Arthritis & Rheumatism. 64:1642-1652
Objective To investigate whether c-Jun and c-Fos contribute to the pathologic activation of fibroblasts in systemic sclerosis (SSc) and to evaluate the antifibrotic potential of selective activator protein 1 (AP-1) inhibition. Methods Expression of c
Autor:
Martial Ruat, Christian Beyer, Oliver Distler, Angelika Horn, Trayana Kireva, Cinzia Cordazzo, Michal Tomcik, Alfiya Akhmetshina, Clara Dees, Georg Schett, Katrin Palumbo-Zerr, Pawel Zerr, Jörg H W Distler
Publikováno v:
Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, BMJ Publishing Group, 2012, epub ahead of print. ⟨10.1136/annrheumdis-2011-200883⟩
Annals of the Rheumatic Diseases, BMJ Publishing Group, 2012, epub ahead of print. ⟨10.1136/annrheumdis-2011-200883⟩
ObjectivesTissue fibrosis is a leading cause of death in patients with systemic sclerosis (SSc). Effective antifibrotic treatments are not available. Here, the authors investigated inhibition of hedgehog signalling by targeting Smoothened (Smo) as a
Autor:
Katrin Palumbo, Christian Beyer, Alfiya Akhmetshina, Pawel Zerr, Clara Dees, Michal Tomcik, Nicole Reich, Georg Schett, Jörg H W Distler, Mark P. Mattson, Angelika Horn, Oliver Distler, Michael Sticherling, Jochen Zwerina
Publikováno v:
Arthritis & Rheumatism. 63:1396-1404
OBJECTIVE: Tissue fibrosis caused by pathologic activation of fibroblasts with increased synthesis of extracellular matrix components is a major hallmark of systemic sclerosis (SSc). Notch signaling regulates tissue differentiation, and abnormal acti
Autor:
Jörg H W Distler, Oliver Distler, Pawel Zerr, Georg Schett, Angelika Horn, Yannick Allanore, Jérôme Avouac, Katrin Palumbo, Christian Beyer, Clara Dees, Alfiya Akhmetshina, Michal Tomcik, Barbara G. Fürnrohr
Publikováno v:
Arthritis & Rheumatism. 63:800-809
OBJECTIVE: The transcription factor STAT-4 has recently been identified as a genetic susceptibility factor in systemic sclerosis (SSc) and other autoimmune diseases. The aim of this study was to investigate the contribution of STAT-4 in the developme
Autor:
Pawel Zerr, Matthias Engel, Jörg H W Distler, Sieglinde Marquart, Katrin Palumbo, Nicole Reich, Alfiya Akhmetshina, Georg Schett, Jochen Zwerina, Michal Tomcik, Angelika Horn, Clara Dees, Oliver Distler
Publikováno v:
Arthritis & Rheumatism. 62:3467-3476
Objective. Cannabinoids are derivates of the marijuana component 9 -tetrahydrocannabinol that exert their effects on mesenchymal cells and immune cells via CB1 and CB2 receptors. The aim of the present study was to evaluate the role of CB1 in systemi
Autor:
Alfiya Distler, Michal Tomcik, Veronika Lang, Jörg H W Distler, Christian Beyer, Oliver Distler, Katrin Palumbo-Zerr, Pawel Zerr, Angelika Horn, Jochen Zwerina, Clara Dees, Kolja Gelse, Georg Schett
Publikováno v:
Arthritis and rheumatism. 64(9)
Objective To investigate whether JAK-2 contributes to the pathologic activation of fibroblasts in patients with systemic sclerosis (SSc) and to evaluate the antifibrotic potential of JAK-2 inhibition for the treatment of SSc. Methods Activation of JA
Autor:
Pawel Zerr, Johannes Gusinde, Martial Ruat, Angelika Horn, Clara Dees, Georg Schett, Oliver Distler, Jérôme Avouac, Katrin Palumbo, Alfiya Akhmetshina, Jörg H W Distler, Hermine Roudaut, Cinzia Cordazzo, Michal Tomcik, Elisabeth Traiffort, Jochen Zwerina
Publikováno v:
Arthritis and Rheumatism
Arthritis and Rheumatism, Wiley, 2012, epub ahead of print. ⟨10.1002/art.34444⟩
Arthritis and Rheumatism, Wiley, 2012, epub ahead of print. 〈10.1002/art.34444〉
Arthritis and Rheumatism, Wiley, 2012, epub ahead of print. ⟨10.1002/art.34444⟩
Arthritis and Rheumatism, Wiley, 2012, epub ahead of print. 〈10.1002/art.34444〉
International audience; PURPOSE: Hedgehog signaling does not only play crucial roles during development, but has also been implicated in the pathogenesis of several diseases in the adult. The aim of the present study was to investigate the role of th
Autor:
Brydon L. Bennett, Jörg H W Distler, Nicole Reich, Oliver Distler, Alfiya Akhmetshina, Christian Beyer, Pawel Zerr, Georg Schett, Clara Dees, Jérôme Avouac, Katrin Palumbo, Angelika Horn, Michal Tomcik, Veronika Lang, Weilin Xie
Publikováno v:
Annals of the rheumatic diseases. 71(5)
ObjectivesThe hallmark of systemic sclerosis (SSc) is the accumulation of extracellular matrix proteins by pathologically activated fibroblasts. This study analysed the antifibrotic effects of the selective c-Jun N-terminal kinase (JNK) inhibitor, CC
Autor:
Wolfgang Baum, Pawel Zerr, G. Ruiz-Heiland, Angelika Horn, Willy Hofstetter, Jörg H W Distler, Georg Schett, Michael Stock, Falk Nimmerjahn, Jochen Zwerina
Publikováno v:
Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases; Vol 71
Annals of the Rheumatic Diseases; Vol 71
BackgroundOsteophyte formation is a common phenomenon in arthritis. Bone formation by endochondral ossification is considered a key pathophysiological process in the formation of osteophytes.ObjectiveTo examine the hypothesis that inhibition of smoot
Autor:
Katrin Palumbo-Zerr, Angelika Horn, Benjamin F. Cravatt, Georg Schett, Pawel Zerr, Jörg H W Distler, Christian Beyer, Enrico Selvi, Oliver Distler, Alfiya Distler, Clara Dees
Background Selective targeting of the cannabinoid receptors CB1 and CB2 by synthetic compounds has revealed opposing roles of both receptors in fibrosis. Objectives To characterise the role of endogenous cannabinoids (endocannabinoids) and their pred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11ec76df73ee617607f05b1c5b17379
https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/7837
https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/7837