Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Angelika Holler"'
Autor:
Abdullah Degirmencay, Sharyn Thomas, Angelika Holler, Samuel Burgess, Emma C. Morris, Hans J. Stauss
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The expression levels of TCRs on the surface of human T cells define the avidity of TCR-HLA/peptide interactions. In this study, we have explored which components of the TCR-CD3 complex are involved in determining the surface expression levels of TCR
Externí odkaz:
https://doaj.org/article/8025343ede7741d989be0574485bfd42
Autor:
Sharyn Thomas, Fiyaz Mohammed, Rogier M. Reijmers, Annemarie Woolston, Theresa Stauss, Alan Kennedy, David Stirling, Angelika Holler, Louisa Green, David Jones, Katherine K. Matthews, David A. Price, Benjamin M. Chain, Mirjam H. M. Heemskerk, Emma C. Morris, Benjamin E. Willcox, Hans J. Stauss
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Increasing TCR cell surface expression can potentiate T cell responses to low-concentrations of antigen. Here the authors identify aminoacids in human TCR variable domains that impact its surface expression, and demonstrate how editing these residues
Externí odkaz:
https://doaj.org/article/b91ffe9fd06f4dd8ae5b0aa7c12c5d8e
Autor:
Bithi Chatterjee, Yun Deng, Angelika Holler, Nicolas Nunez, Tarik Azzi, Liliana Danusia Vanoaica, Anne Müller, Hana Zdimerova, Olga Antsiferova, Andrea Zbinden, Riccarda Capaul, Johannes H Dreyer, David Nadal, Burkhard Becher, Mark D Robinson, Hans Stauss, Christian Münz
Publikováno v:
PLoS Pathogens, Vol 15, Iss 5, p e1007748 (2019)
Epstein Barr virus (EBV) is one of the most ubiquitous human pathogens in the world, persistently infecting more than 90% of the adult human population. It drives some of the strongest human CD8+ T cell responses, which can be observed during symptom
Externí odkaz:
https://doaj.org/article/1c51aad6aa5f4c7680263e91d52a806d
Publikováno v:
OncoImmunology, Vol 8, Iss 3 (2019)
We explored whether engineering of T cell specificity and effector function improves immunotherapy of solid tumors. Although IL-12 can enhance cancer immunity, a strategy of safe IL-12 delivery without toxicity is currently lacking. We engineered T c
Externí odkaz:
https://doaj.org/article/63c3d994cc1d4e65b2f01429dcdcd776
Publikováno v:
Cells, Vol 9, Iss 7, p 1721 (2020)
This review presents key advances in combining T cell receptor (TCR) gene transfer to redirect T-cell specificity with gene engineering in order to enhance cancer-protective immune function. We discuss how emerging insights might be applied to CD4+ T
Externí odkaz:
https://doaj.org/article/a95293fbde74437f90725d3579861898
Autor:
Angelika Holler, Mathias Zech, Sara Ghorashian, Rebecca Pike, Alastair Hotblack, Pedro Veliça, Shao-An Xue, Ronjon Chakraverty, Emma C. Morris, Hans J. Stauss
Publikováno v:
Haematologica, Vol 101, Iss 4 (2016)
Due to the lack of specificity for tumor antigens, allogeneic T-cell therapy is associated with graft-versus-host disease. Enhancing the anti-tumor specificity while reducing the graft-versus-host disease risk of allogeneic T cells has remained a res
Externí odkaz:
https://doaj.org/article/832853b6cf9444438aff1b61e124f0a5
Publikováno v:
PLoS ONE, Vol 2, Iss 4, p e353 (2007)
Most tumor-associated antigens (TAA) currently used for immunotherapy of cancer are also expressed in normal tissues, which may induce tolerance and impair T cell-mediated immunity. However, there is limited information about how physiological expres
Externí odkaz:
https://doaj.org/article/61e8c3d9adfd4ab79995e7f84fbc53ab
Autor:
Ronjon Chakraverty, Hans Stauss, Martin Pule, Bernhard Schiedlmeier, Lei Zhang, Pedro Santos e Sousa, Rebecca Pike, Teresa Manzo, Angelika Holler, Sian Henson, Mathias Zech, Pedro Veliça
Supplementary methods for flow cytometry and retroviral construct generation. Supplementary Figure 1. Expression of activated caspase-3 in CD8+ T cells overexpressing RHEB or PRAS40. Supplementary Figure 2. Expression of CD25 and CD69 in CD8+ T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc86460510f3b231fc2cbbccfdfb81f
https://doi.org/10.1158/0008-5472.22405631.v1
https://doi.org/10.1158/0008-5472.22405631.v1
Publikováno v:
Journal of autoimmunity. 132
Regulatory T cells (Treg) are potent inhibitors of autoreactive T cells. The intracellular transcription factor FoxP3 controls the expression levels of a diverse set of genes and plays a critical role in programming functional Tregs. Although, antige
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c33fd5f0f7c85ca3464885081260658
https://pubmed.ncbi.nlm.nih.gov/36049437
https://pubmed.ncbi.nlm.nih.gov/36049437
Autor:
Patrick Schuhmachers, Antonino Bongiovanni, Hans J. Stauss, Kyra D. Zens, Angelika Holler, Yun Deng, Hana Zdimerova, Riccarda Capaul, Andrea Zbinden, Laure-Anne Ligeon, Wolfgang Hammerschmidt, Christian Münz, Anne Müller, Bithi Chatterjee
Publikováno v:
Blood
Blood 137, 3225-3236 (2021)
Blood 137, 3225-3236 (2021)
Primary immunodeficiencies in the costimulatory molecule CD27 and its ligand, CD70, predispose for pathologies of uncontrolled Epstein-Barr virus (EBV) infection in nearly all affected patients. We demonstrate that both depletion of CD27+ cells and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2da541c494b463dea06dc799466592
https://doi.org/10.1182/blood.2020009482
https://doi.org/10.1182/blood.2020009482