Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Angelika Feldmann"'
Autor:
Helena G. Asenjo, María Alcazar-Fabra, Mencía Espinosa-Martínez, Lourdes Lopez-Onieva, Amador Gallardo, Emilia Dimitrova, Angelika Feldmann, Tomas Pachano, Jordi Martorell-Marugán, Pedro Carmona-Sáez, Antonio Sanchez-Pozo, Álvaro Rada-Iglesias, Robert J. Klose, David Landeira
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Changes in Polycomb repression during interphase transition modulate the ability of pluripotent cells to enter cell differentiation.
Externí odkaz:
https://doaj.org/article/969d96608f7f483d97169ae175d3c01a
Autor:
Paul Adrian Ginno, Dimos Gaidatzis, Angelika Feldmann, Leslie Hoerner, Dilek Imanci, Lukas Burger, Frederic Zilbermann, Antoine H. F. M. Peters, Frank Edenhofer, Sébastien A. Smallwood, Arnaud R. Krebs, Dirk Schübeler
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Local activity of the DNA methylation machinery remains poorly understood. Here, the authors present a theoretical and experimental framework to infer methylation and demethylation rates at genome scale in mouse embryonic stem cells, finding that mai
Externí odkaz:
https://doaj.org/article/d71bbc029bb84f98b2659275c30cb32d
Autor:
James D.P. Rhodes, Angelika Feldmann, Benjamín Hernández-Rodríguez, Noelia Díaz, Jill M. Brown, Nadezda A. Fursova, Neil P. Blackledge, Praveen Prathapan, Paula Dobrinic, Miles K. Huseyin, Aleksander Szczurek, Kai Kruse, Kim A. Nasmyth, Veronica J. Buckle, Juan M. Vaquerizas, Robert J. Klose
Publikováno v:
Cell Reports, Vol 30, Iss 3, Pp 820-835.e10 (2020)
Summary: How chromosome organization is related to genome function remains poorly understood. Cohesin, loop extrusion, and CCCTC-binding factor (CTCF) have been proposed to create topologically associating domains (TADs) to regulate gene expression.
Externí odkaz:
https://doaj.org/article/04343456c33648c2bdd2312d131af175
Autor:
David A. Brown, Vincenzo Di Cerbo, Angelika Feldmann, Jaewoo Ahn, Shinsuke Ito, Neil P. Blackledge, Manabu Nakayama, Michael McClellan, Emilia Dimitrova, Anne H. Turberfield, Hannah K. Long, Hamish W. King, Skirmantas Kriaucionis, Lothar Schermelleh, Tatiana G. Kutateladze, Haruhiko Koseki, Robert J. Klose
Publikováno v:
Cell Reports, Vol 20, Iss 10, Pp 2313-2327 (2017)
Chromatin modifications and the promoter-associated epigenome are important for the regulation of gene expression. However, the mechanisms by which chromatin-modifying complexes are targeted to the appropriate gene promoters in vertebrates and how th
Externí odkaz:
https://doaj.org/article/9b58edca6b994f178ed582935538118f
Autor:
Emilia Dimitrova, Takashi Kondo, Angelika Feldmann, Manabu Nakayama, Yoko Koseki, Rebecca Konietzny, Benedikt M Kessler, Haruhiko Koseki, Robert J Klose
Publikováno v:
eLife, Vol 7 (2018)
CpG islands are gene regulatory elements associated with the majority of mammalian promoters, yet how they regulate gene expression remains poorly understood. Here, we identify FBXL19 as a CpG island-binding protein in mouse embryonic stem (ES) cells
Externí odkaz:
https://doaj.org/article/e1ac4beed4eb453a8c6554167bc7f70f
Autor:
Vincenzo Di Cerbo, Fabio Mohn, Daniel P Ryan, Emilie Montellier, Salim Kacem, Philipp Tropberger, Eleni Kallis, Monika Holzner, Leslie Hoerner, Angelika Feldmann, Florian Martin Richter, Andrew J Bannister, Gerhard Mittler, Jens Michaelis, Saadi Khochbin, Robert Feil, Dirk Schuebeler, Tom Owen-Hughes, Sylvain Daujat, Robert Schneider
Publikováno v:
eLife, Vol 3 (2014)
Post-translational modifications of proteins have emerged as a major mechanism for regulating gene expression. However, our understanding of how histone modifications directly affect chromatin function remains limited. In this study, we investigate a
Externí odkaz:
https://doaj.org/article/0b9dc66f95514665a40c71e1cf656ece
Transcription factor occupancy can mediate active turnover of DNA methylation at regulatory regions.
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1003994 (2013)
Distal regulatory elements, including enhancers, play a critical role in regulating gene activity. Transcription factor binding to these elements correlates with Low Methylated Regions (LMRs) in a process that is poorly understood. Here we ask whethe
Externí odkaz:
https://doaj.org/article/a8e985109e104cbfb7c573e1c3f4a205
Autor:
Helena G. Asenjo, María Alcazar-Fabra, Mencía Espinosa, Lourdes Lopez-Onieva, Amador Gallardo, Emilia Dimitrova, Angelika Feldmann, Tomas Pachano, Jordi Martorell-Marugán, Pedro Carmona-Sáez, Antonio Sanchez-Pozo, Álvaro Rada-Iglesias, Robert J. Klose, David Landeira
The potential of pluripotent cells to respond to developmental cues and trigger cell differentiation is enhanced during the G1 phase of the cell cycle, but the molecular mechanisms involved are poorly understood. Variations in polycomb activity durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::224f1399fd00e85b103b23e107ff63f2
https://doi.org/10.1101/2022.07.26.501502
https://doi.org/10.1101/2022.07.26.501502
Autor:
Angelika Feldmann, Lukas Burger, Sébastien A. Smallwood, Arnaud R Krebs, Frederic Zilbermann, Paul A. Ginno, Dirk Schübeler, Dilek Imanci, Dimos Gaidatzis, Leslie Hoerner, Antoine H.F.M. Peters, Frank Edenhofer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature
Nature Communications
Nature
DNA methylation is considered a stable epigenetic mark, yet methylation patterns can vary during differentiation and in diseases such as cancer. Local levels of DNA methylation result from opposing enzymatic activities, the rates of which remain larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be47f993bbed074d0fa4f3ddd6fb02df
http://link.springer.com/article/10.1038/s41467-020-16354-x
http://link.springer.com/article/10.1038/s41467-020-16354-x
Publikováno v:
Nucleic Acids Research
Appropriate developmental gene regulation relies on the capacity of gene promoters to integrate inputs from distal regulatory elements, yet how this is achieved remains poorly understood. In embryonic stem cells (ESCs), a subset of silent development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe43a8af5e92a892112c10a6eba00ec5
http://europepmc.org/articles/PMC7102981
http://europepmc.org/articles/PMC7102981