Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Angelika Dorn"'
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 7, Pp o1867-o1867 (2010)
In the title compound, C29H24N2O2, the two aromatic rings of the tricyclic unit are oriented at a dihedral angle of 32.27 (8)°. In the crystal N—H...O hydrogen bonds link the molecules into chains along the a axis. Further N—H...·O interactions
Externí odkaz:
https://doaj.org/article/0a58034805a941a0b0b115f1d98a9589
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 5, Pp o1149-o1149 (2010)
In the title compound, C14H11F3N2O, the two aromatic rings are oriented at a dihedral angle of 70.84 (8)°. The crystal structure displays intermolecular N—H...O and N—H...F interactions.
Externí odkaz:
https://doaj.org/article/040575aa45b848cea9f98f83cb62b2fc
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 5, Pp o1100-o1100 (2010)
In the title compound, C26H20N2O3, the two aromatic rings of the tricyclic unit are oriented at a dihedral angle of 54.53 (9)°. The crystal structure displays intermolecular N—H...O hydrogen bonding.
Externí odkaz:
https://doaj.org/article/83175ea31901444686eb90a7f2532aee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3074-3077
The p38 MAP kinase is a key enzyme in inflammatory diseases as it is involved in the biosynthesis of proinflammatory cytokines such as TNF-alpha and IL-1beta. Small molecule p38 inhibitors suppress the production of these cytokines and therefore p38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5962e3596d929b4f08190e091cbb3436
https://doi.org/10.1016/j.bmcl.2010.03.107
https://doi.org/10.1016/j.bmcl.2010.03.107
Autor:
Márcia Inês Goettert, Daniel Rauh, Verena Schattel, Kathrin E. Martz, Stefan Laufer, Svenja C. Mayer-Wrangowski, Benjamin Baur, Angelika Dorn
Publikováno v:
Journal of medicinal chemistry. 55(17)
The p38 MAP kinase is a key player in signaling pathways regulating the biosynthesis of inflammatory cytokines. Small molecule p38 inhibitors suppress the production of these cytokines. Therefore p38 is a promising drug target for novel anti-inflamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4909598d78a4f736479ae0c9dbe7d265
https://pubmed.ncbi.nlm.nih.gov/22897496
https://pubmed.ncbi.nlm.nih.gov/22897496
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 5, Pp o1100-o1100 (2010)
Acta Crystallographica Section E: Structure Reports
Acta Crystallographica Section E: Structure Reports
In the title compound, C26H20N2O3, the two aromatic rings of the tricyclic unit are oriented at a dihedral angle of 54.53 (9)°. The crystal structure displays intermolecular N—H...O hydrogen bonding.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94889e02026a973ddeca8dbf1aebf98e
http://scripts.iucr.org/cgi-bin/paper?S1600536810013450
http://scripts.iucr.org/cgi-bin/paper?S1600536810013450
Publikováno v:
Acta Crystallographica Section E: Structure Reports
Acta Crystallographica Section E, Vol 66, Iss 7, Pp o1867-o1867 (2010)
Acta Crystallographica Section E, Vol 66, Iss 7, Pp o1867-o1867 (2010)
In the title compound, C29H24N2O2, the two aromatic rings of the tricyclic unit are oriented at a dihedral angle of 32.27 (8)°. In the crystal N—H...O hydrogen bonds link the molecules into chains along the a axis. Further N—H...·O interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6155a0680ad2a18c9be561f7e4fb0823
http://europepmc.org/articles/PMC3006722
http://europepmc.org/articles/PMC3006722