Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Angelika Doetzlhofer"'
Autor:
Meenakshi Prajapati-DiNubila, Ana Benito-Gonzalez, Erin Jennifer Golden, Shuran Zhang, Angelika Doetzlhofer
Publikováno v:
eLife, Vol 8 (2019)
The mammalian auditory sensory epithelium has one of the most stereotyped cellular patterns known in vertebrates. Mechano-sensory hair cells are arranged in precise rows, with one row of inner and three rows of outer hair cells spanning the length of
Externí odkaz:
https://doaj.org/article/bab677c29fa7438d8a32ec56ccfe1007
Autor:
Xiao-Jun Li, Charles Morgan, Prathamesh T Nadar-Ponniah, Waldemar Kolanus, Angelika Doetzlhofer
Publikováno v:
bioRxiv
Cochlear hair cell loss is a leading cause of deafness in humans. Neighboring supporting cells have some capacity to regenerate hair cells. However, their regenerative potential sharply declines as supporting cells undergo maturation (postnatal day 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e5f0805ed1d1b492e25984371822bd
https://europepmc.org/articles/PMC9882147/
https://europepmc.org/articles/PMC9882147/
Autor:
Hei Yeun Koo, Min-A Kim, Hyehyun Min, Jae Yeon Hwang, Meenakshi Prajapati-DiNubila, Kwan Soo Kim, Martin M. Matzuk, Juw Won Park, Angelika Doetzlhofer, Un-Kyung Kim, Jinwoong Bok
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 120(1)
The cochlea’s ability to discriminate sound frequencies is facilitated by a special topography along its longitudinal axis known as tonotopy. Auditory hair cells located at the base of the cochlea respond to high-frequency sounds, whereas hair cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b4d1bde8060818971ef77daefccddd1
https://pubmed.ncbi.nlm.nih.gov/36577057
https://pubmed.ncbi.nlm.nih.gov/36577057
Autor:
Martin L Basch, Rogers M Brown II, Hsin-I Jen, Fatih Semerci, Frederic Depreux, Renée K Edlund, Hongyuan Zhang, Christine R Norton, Thomas Gridley, Susan E Cole, Angelika Doetzlhofer, Mirjana Maletic-Savatic, Neil Segil, Andrew K Groves
Publikováno v:
eLife, Vol 5 (2016)
The signals that induce the organ of Corti and define its boundaries in the cochlea are poorly understood. We show that two Notch modifiers, Lfng and Mfng, are transiently expressed precisely at the neural boundary of the organ of Corti. Cre-Lox fate
Externí odkaz:
https://doaj.org/article/ef349eec4d0042e7ac246fa6ab85e782
Autor:
Angelika Doetzlhofer, Kaley A. Graves, Brandon C. Cox, Elena Chrysostomou, Luyi Zhou, Yuanzhao L. Darcy
Publikováno v:
J Neurosci
During cochlear development, the Notch ligand JAGGED 1 (JAG1) plays an important role in the specification of the prosensory region, which gives rise to sound-sensing hair cells and neighboring supporting cells (SCs). While JAG1's expression is maint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0c0af619deefeddcc9b9701957f931
https://doi.org/10.1523/jneurosci.1192-20.2020
https://doi.org/10.1523/jneurosci.1192-20.2020
Autor:
Xiaojun Li, Angelika Doetzlhofer
Publikováno v:
XIAOJUN LI
Mechano-sensory hair cells within the inner ear cochlea are essential for the detection of sound. In mammals, cochlear hair cells are only produced during development and their loss, due to disease or trauma, is a leading cause of deafness. In the im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5fe13df8c54f02898eac98f42aa504
https://doi.org/10.1073/pnas.2000417117
https://doi.org/10.1073/pnas.2000417117
Publikováno v:
Science advances. 8(6)
Hair cell (HC) loss within the inner ear cochlea is a leading cause for deafness in humans. Before the onset of hearing, immature supporting cells (SCs) in neonatal mice have some limited capacity for HC regeneration. Here, we show that in organoid c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e81bb849a8497bdc9562a390c8feec
https://pubmed.ncbi.nlm.nih.gov/35148175
https://pubmed.ncbi.nlm.nih.gov/35148175
Autor:
Phan Q. Duy, Stefan C. Weise, Claudia Marini, Xiao-Jun Li, Dan Liang, Peter J. Dahl, Shaojie Ma, Ana Spajic, Weilai Dong, Jane Juusola, Emre Kiziltug, Adam J. Kundishora, Sunil Koundal, Maysam Z. Pedram, Lucia A. Torres-Fernández, Kristian Händler, Elena De Domenico, Matthias Becker, Thomas Ulas, Stefan A. Juranek, Elisa Cuevas, Le Thi Hao, Bettina Jux, André M. M. Sousa, Fuchen Liu, Suel-Kee Kim, Mingfeng Li, Yiying Yang, Yutaka Takeo, Alvaro Duque, Carol Nelson-Williams, Yonghyun Ha, Kartiga Selvaganesan, Stephanie M. Robert, Amrita K. Singh, Garrett Allington, Charuta G. Furey, Andrew T. Timberlake, Benjamin C. Reeves, Hannah Smith, Ashley Dunbar, Tyrone DeSpenza, June Goto, Arnaud Marlier, Andres Moreno-De-Luca, Xin Yu, William E. Butler, Bob S. Carter, Evelyn M. R. Lake, R. Todd Constable, Pasko Rakic, Haifan Lin, Engin Deniz, Helene Benveniste, Nikhil S. Malvankar, Juvianee I. Estrada-Veras, Christopher A. Walsh, Seth L. Alper, Joachim L. Schultze, Katrin Paeschke, Angelika Doetzlhofer, F. Gregory Wulczyn, Sheng Chih Jin, Richard P. Lifton, Nenad Sestan, Waldemar Kolanus, Kristopher T. Kahle
Publikováno v:
Nat Neurosci
Nature neuroscience 25(4), 458-473 (2022). doi:10.1038/s41593-022-01043-3
Nature neuroscience 25(4), 458-473 (2022). doi:10.1038/s41593-022-01043-3
Hydrocephalus, characterized by cerebral ventricular dilatation, is routinely attributed to primary defects in cerebrospinal fluid (CSF) homeostasis. This fosters CSF shunting as the leading reason for brain surgery in children despite considerable d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7188034c8e54b35384ea495840fb8d5
https://pubmed.ncbi.nlm.nih.gov/35379995
https://pubmed.ncbi.nlm.nih.gov/35379995
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e73276 (2013)
In mammals, auditory hair cells are generated only during embryonic development and loss or damage to hair cells is permanent. However, in non-mammalian vertebrate species, such as birds, neighboring glia-like supporting cells regenerate auditory hai
Externí odkaz:
https://doaj.org/article/cdd2afc5816f4d0ca3475b71d9549445
Autor:
Xiao-Jun, Li, Angelika, Doetzlhofer
Publikováno v:
Proc Natl Acad Sci U S A
Mechano-sensory hair cells within the inner ear cochlea are essential for the detection of sound. In mammals, cochlear hair cells are only produced during development and their loss, due to disease or trauma, is a leading cause of deafness. In the im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ed39ad8eda35b06435e480ad0cf3b4ce
https://pubmed.ncbi.nlm.nih.gov/32826333
https://pubmed.ncbi.nlm.nih.gov/32826333