Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Angelika Długosz-Pokorska"'
Autor:
Anna Laskowska, Agata J. Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Aneta Jastrzębska, Angelika Długosz-Pokorska, Katarzyna Gach-Janczak, Jacek Ścianowski
Publikováno v:
Molecules, Vol 29, Iss 12, p 2866 (2024)
A series of phenyl β-carbonyl selenides with o-ester functionality substituted on the oxygen atom with chiral and achiral alkyl groups was synthesized. All compounds are the first examples of this type of organoselenium derivatives with an ester sub
Externí odkaz:
https://doaj.org/article/5218e63f94214e17bdf16bc3d92229a9
Autor:
Anna Laskowska, Agata J. Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Aneta Jastrzębska, Angelika Długosz-Pokorska, Katarzyna Gach-Janczak, Jacek Ścianowski
Publikováno v:
Materials, Vol 17, Iss 4, p 899 (2024)
A series of unsymmetrical phenyl β-carbonyl selenides with o-amido function substituted on the nitrogen atom with chiral alkyl groups was obtained. The compounds form a series of enantiomeric and diastereomeric pairs and present the first examples o
Externí odkaz:
https://doaj.org/article/495b6bdf8960448a9f6e2bd25885726c
Autor:
Agata J. Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Aneta Jastrzębska, Angelika Długosz-Pokorska, Katarzyna Gach-Janczak, Jacek Ścianowski
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1560 (2023)
Organoselenium compounds are well-known for their numerous biocapacities, which result from the uniqueness of the selenium atom and the possibility of constructing heterorganic molecules that can mimic the activity of selenoenzymes, crucial for a mul
Externí odkaz:
https://doaj.org/article/d91228dcfd3a4535a238ddd8c50d02c0
Publikováno v:
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-10 (2020)
Abstract Background 5-Fluorouracil (5-FU) is an antimetabolite that interferes with DNA synthesis and has been widely used as a chemotherapeutic drug in various types of cancers. However, the development of drug resistance greatly limits its applicat
Externí odkaz:
https://doaj.org/article/123e1cae83724f0fab73cacdd67d6563
Autor:
Anna Laskowska, Agata Joanna Pacuła-Miszewska, Angelika Długosz-Pokorska, Anna Janecka, Andrzej Wojtczak, Jacek Ścianowski
Publikováno v:
Materials, Vol 15, Iss 6, p 2068 (2022)
A series of new chiral benzisoselenazol-3(2H)-ones and their corresponding diselenides bearing an o-amido function substituted on the nitrogen atom with various aliphatic and aromatic moieties were synthesized. All derivatives representing pairs of e
Externí odkaz:
https://doaj.org/article/a4c5202b186a4e1a91b67de65e5815c7
Autor:
Katarzyna Gach-Janczak, Joanna Drogosz-Stachowicz, Angelika Długosz-Pokorska, Rafał Jakubowski, Tomasz Janecki, Jacek Szymański, Anna Janecka
Publikováno v:
Molecules, Vol 25, Iss 7, p 1479 (2020)
In the search for new drug candidates, researchers turn to natural substances isolated from plants which may be either used directly or may serve as a source for chemical modifications. An interesting strategy in the design of novel anticancer agents
Externí odkaz:
https://doaj.org/article/e057b219b9af4f31add579300f8945b4
Autor:
Magdalena Obieziurska, Agata J. Pacuła, Anna Laskowska, Angelika Długosz-Pokorska, Anna Janecka, Jacek Ścianowski
Publikováno v:
Materials, Vol 13, Iss 3, p 661 (2020)
Organoselenium compounds are well-known glutathione peroxidase (GPx) mimetics that possess antioxidants/prooxidant properties and are able to modulate the concentration of reactive oxygen species (ROS), preventing oxidative stress in normal cells or
Externí odkaz:
https://doaj.org/article/4e6677d7a13e4cfb9a2b915060a63715
Autor:
Magdalena Obieziurska, Agata J. Pacuła, Angelika Długosz-Pokorska, Marek Krzemiński, Anna Janecka, Jacek Ścianowski
Publikováno v:
Materials, Vol 12, Iss 21, p 3579 (2019)
A series of new chiral benzisoselenazol-3(2H)-ones substituted on the nitrogen atom with three monoterpene moieties—p-menthane, pinane and carane—was synthesized. The compounds were obtained by the reaction of 2-(chloroseleno)benzoyl chloride wit
Externí odkaz:
https://doaj.org/article/7d11db5dbb184a0c93b58e078f8341b3
Publikováno v:
Biologics: Targets and Therapy.
Angelika Długosz-Pokorska,1 Renata Perlikowska,1 Tomasz Janecki,2 Anna Janecka1 1Department of Biomolecular Chemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland; 2Institute of Organic Chemistry, Faculty of Chemistry, Lodz U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f61fa3466679e905dad576fcc4ffa2d
https://www.dovepress.com/new-uracil-analog-with-exocyclic-methylidene-group-can-reverse-resista-peer-reviewed-fulltext-article-BTT
https://www.dovepress.com/new-uracil-analog-with-exocyclic-methylidene-group-can-reverse-resista-peer-reviewed-fulltext-article-BTT
Publikováno v:
Molecular Biology Reports. 46:5831-5839
Overexpression of ATP-binding cassette (ABC) transporters causing multidrug resistance (MDR) in cancer cells is one of the major obstacles in cancer chemotherapy. The 5-FU resistant subclone (HL-60/5FU) of the human HL-60 promyelocytic leukemia cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2986c815158deeaeaee3f0c384b1f51d
https://doi.org/10.1007/s11033-019-05017-w
https://doi.org/10.1007/s11033-019-05017-w