Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Angelika BRÖER"'
Autor:
Junyang Xu, Ziwei Hu, Lu Dai, Aditya Yadav, Yashan Jiang, Angelika Bröer, Michael G. Gardiner, Malcolm McLeod, Renhong Yan, Stefan Bröer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The epithelial neutral amino acid transporter B0AT1 (SLC6A19) is the major transporter for the absorption of neutral amino acids in the intestine and their reabsorption in the kidney. Mouse models have demonstrated that lack of B0AT1 can nor
Externí odkaz:
https://doaj.org/article/f84e5f5f3bc548c8ad53564c9dd50aa8
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The Alanine-Serine-Cysteine transporter 1 (Asc-1 or SLC7A10) forms a crucial heterodimeric transporter complex with 4F2hc (SLC3A2) through a covalent disulfide bridge. This complex enables the sodium-independent transport of small neutral am
Externí odkaz:
https://doaj.org/article/045b70bef7a44127a2798b8eef9aa805
Publikováno v:
Metabolites, Vol 13, Iss 10, p 1064 (2023)
The integrated stress response is a signaling network comprising four branches, each sensing different cellular stressors, converging on the phosphorylation of eIF2α to downregulate global translation and initiate recovery. One of these branches inc
Externí odkaz:
https://doaj.org/article/db0cb7061c5b4542918ace40c6430639
Autor:
Gregory Gauthier-Coles, Jade Vennitti, Zhiduo Zhang, William C. Comb, Shuran Xing, Kiran Javed, Angelika Bröer, Stefan Bröer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Cytosolic amino acid concentrations are carefully maintained, but how homeostasis occurs is unclear. Here, the authors show that amino acid transporters primarily determine intracellular amino acid levels and develop a model that predicts a perturbat
Externí odkaz:
https://doaj.org/article/33b82f1c4d6d4f39ae9daaf65ccf7097
Autor:
Gregory Gauthier-Coles, Angelika Bröer, Malcolm Donald McLeod, Amee J. George, Ross D. Hannan, Stefan Bröer
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
SNAT2 (SLC38A2) is a sodium-dependent neutral amino acid transporter, which is important for the accumulation of amino acids as nutrients, the maintenance of cellular osmolarity, and the activation of mTORC1. It also provides net glutamine for glutam
Externí odkaz:
https://doaj.org/article/d3c5f668b94241c1afb16ed8958abd50
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 301 (2023)
Amino acid antiporters mediate the 1:1 exchange of groups of amino acids. Whether substrate specificity can be different for the inward and outward facing conformation has not been investigated systematically, although examples of asymmetric transpor
Externí odkaz:
https://doaj.org/article/74e5a6aa94fd491f93eac758699d657d
Autor:
Stephen J. Fairweather, Shoko Okada, Gregory Gauthier-Coles, Kiran Javed, Angelika Bröer, Stefan Bröer
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Amino acid transporters play a vital role in metabolism and nutrient signaling pathways. Typically, transport activity is investigated using single substrates and competing amounts of other amino acids. We used GC-MS and LC-MS for metabolic screening
Externí odkaz:
https://doaj.org/article/0def0be3c75442ab837a5efc68a8c8be
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The glutamine transporter ASCT2 (SLC1A5) is actively investigated as an oncological target, but the field lacks efficient ASCT2 inhibitors. A new group of ASCT2 inhibitors, 2-amino-4-bis(aryloxybenzyl)aminobutanoic acids (AABA), were developed recent
Externí odkaz:
https://doaj.org/article/e989b87540d84f1f90a0865627e271da
Autor:
Yang Jiang, Adam J. Rose, Tjeerd P. Sijmonsma, Angelika Bröer, Anja Pfenninger, Stephan Herzig, Dieter Schmoll, Stefan Bröer
Publikováno v:
Molecular Metabolism, Vol 4, Iss 5, Pp 406-417 (2015)
Objective: Type 2 diabetes arises from insulin resistance of peripheral tissues followed by dysfunction of β-cells in the pancreas due to metabolic stress. Both depletion and supplementation of neutral amino acids have been discussed as strategies t
Externí odkaz:
https://doaj.org/article/33f1cb22266c469b948b7aa7cf9df073
ASCT2 (SLC1A5)-Deficient Mice Have Normal B-Cell Development, Proliferation, and Antibody Production
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
SLC1A5 (solute carrier family 1, member 5) is a small neutral amino acid exchanger that is upregulated in rapidly proliferating lymphocytes but also in many primary human cancers. Furthermore, cancer cell lines have been shown to require SLC1A5 for t
Externí odkaz:
https://doaj.org/article/49b10148616c48af908c7ec0b1db5af4