Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Angelika B, Harbauer"'
Publikováno v:
Cells, Vol 10, Iss 12, p 3436 (2021)
Established disease models have helped unravel the mechanistic underpinnings of pathological phenotypes in Parkinson’s disease (PD), the second most common neurodegenerative disorder. However, these discoveries have been limited to relatively simpl
Externí odkaz:
https://doaj.org/article/ae819050b53c443b91d8cfebcf70bee6
Publikováno v:
Annual Review of Analytical Chemistry. 15:1-16
Cellular organelles are highly specialized compartments with distinct functions. With the increasing resolution of detection methods, it is becoming clearer that same organelles may have different functions or properties not only within different cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f43cee6fea6e5d5a38700955f700ceb
https://doi.org/10.1146/annurev-anchem-061020-111722
https://doi.org/10.1146/annurev-anchem-061020-111722
Autor:
J. Tabitha Hees, Angelika B. Harbauer
Mitochondrial quality control failure is frequently observed in neurodegenerative diseases. The detection of damaged mitochondria by stabilization of PTEN-induced kinase 1 (PINK1) requires transport ofPink1mRNA by tethering it to the mitochondrial su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::370cf0abdd87d28c6ec47f0a85146fa0
https://doi.org/10.1101/2023.02.06.527276
https://doi.org/10.1101/2023.02.06.527276
Publikováno v:
Journal of visualized experiments : JoVE. (186)
Mitochondria are the primary suppliers of ATP (adenosine triphosphate) in neurons. Mitochondrial dysfunction is a common phenotype in many neurodegenerative diseases. Given some axons' elaborate architecture and extreme length, it is not surprising t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e418293826df792d04c527351ad318a
https://pubmed.ncbi.nlm.nih.gov/35993756
https://pubmed.ncbi.nlm.nih.gov/35993756
Autor:
J Tabitha, Hees, Angelika B, Harbauer
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2431
The use of fluorescent proteins has revolutionized the study of protein localization and transport. However, the visualization of other molecules and specifically RNA during live-cell imaging remains challenging. In this chapter, we provide guidance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::975c7ddd1432640381bfce61a478c99c
https://pubmed.ncbi.nlm.nih.gov/35412279
https://pubmed.ncbi.nlm.nih.gov/35412279
Autor:
J. Tabitha Hees, Angelika B. Harbauer
Publikováno v:
Methods in Molecular Biology ISBN: 9781071619896
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39806aff6bfff45914475e50ca58c1c6
https://doi.org/10.1007/978-1-0716-1990-2_11
https://doi.org/10.1007/978-1-0716-1990-2_11
Autor:
Angelika B. Harbauer, J. Tabitha Hees, Simone Wanderoy, Inmaculada Segura, Whitney Gibbs, Yiming Cheng, Martha Ordonez, Zerong Cai, Romain Cartoni, Ghazaleh Ashrafi, Chen Wang, Fabiana Perocchi, Zhigang He, Thomas L. Schwarz
Publikováno v:
Neuron 110, 1516-1531.e9 (2022)
PTEN-induced kinase 1 (PINK1) is a short-lived protein required for the removal of damaged mitochondria through Parkin translocation and mitophagy. Because the short half-life of PINK1 limits its ability to be trafficked into neurites, local translat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa706e9325823230f048bfb2512a6aa
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=64542
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=64542
Publikováno v:
Advanced Biology
Mitochondria are the main suppliers of neuronal adenosine triphosphate and play a critical role in brain energy metabolism. Mitochondria also serve as Ca2+ sinks and anabolic factories and are therefore essential for neuronal function and survival. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd737508dac3939c8b9e169485fa0e96
https://hdl.handle.net/21.11116/0000-0009-9A31-221.11116/0000-0009-9A33-0
https://hdl.handle.net/21.11116/0000-0009-9A31-221.11116/0000-0009-9A33-0
Autor:
Laura Strohm, Zehan Hu, Yongwon Suk, Alina Rühmkorf, Erin Sternburg, Vanessa Gattringer, Henrick Riemenschneider, Riccardo Berutti, Elisabeth Graf, Jochen H Weishaupt, Monika S Brill, Angelika B Harbauer, Dorothee Dormann, Jörn Dengjel, Dieter Edbauer, Christian Behrends
Publikováno v:
Life science alliance 5(11), e202101327 (2022). doi:10.26508/lsa.202101327
Ubiquilin-2 (UBQLN2) is a ubiquitin-binding protein that shuttles ubiquitinated proteins to proteasomal and autophagic degradation. UBQLN2 mutations are genetically linked to the neurodegenerative disorders amyotrophic lateral sclerosis and frontotem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::999c052f873cd378aead73b0b3b1e8b6
https://doi.org/10.26508/lsa.202101327
https://doi.org/10.26508/lsa.202101327
Publikováno v:
Biological Chemistry
Mitochondria are key players of cellular metabolism, Ca2+ homeostasis, and apoptosis. The functionality of mitochondria is tightly regulated, and dysfunctional mitochondria are removed via mitophagy, a specialized form of autophagy that is compromise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d447c5db4025e6e57a8220a632dc6b
https://hdl.handle.net/21.11116/0000-0007-AAC1-F21.11116/0000-0007-AAC3-D
https://hdl.handle.net/21.11116/0000-0007-AAC1-F21.11116/0000-0007-AAC3-D