Non-HLA antibodies targeting angiotensin II Type 1 receptor and endothelin-1 Type A receptors induce endothelial injury via β2-arrestin link to mTOR pathway

Autor: Oskar Wischnewski, Angelika Kusch, Claudia Rutz, Lei Chen, Duska Dragun, Rusan Catar, Harald Heidecke, Ralf Schülein, Aurélie Philippe

Publikováno v: Kidney International. 101:498-509

Functional non-HLA antibodies (antibodies to non-human leukocyte antigens) targeting the G protein-coupled receptors angiotensin II type 1 receptor (AT1R) and endothelin-1 type A receptor (ETAR) are implicated in the pathogenesis of transplant vascul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5243a1be7700375918ed43d213ef457d
https://doi.org/10.1016/j.kint.2021.09.029

Autoantibodies Targeting AT1- and ETA-Receptors Link Endothelial Proliferation and Coagulation via Ets-1 Transcription Factor

Autor: Rusan Catar, Melanie Herse-Naether, Nan Zhu, Philine Wagner, Oskar Wischnewski, Angelika Kusch, Julian Kamhieh-Milz, Andreas Eisenreich, Ursula Rauch, Björn Hegner, Harald Heidecke, Angela Kill, Gabriela Riemekasten, Gunnar Kleinau, Patrick Scheerer, Duska Dragun, Aurelie Philippe

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 244
International Journal of Molecular Sciences, Vol 23, Iss 244, p 244 (2022)
International Journal of Molecular Sciences

Scleroderma renal crisis (SRC) is an acute life-threatening manifestation of systemic sclerosis (SSc) caused by obliterative vasculopathy and thrombotic microangiopathy. Evidence suggests a pathogenic role of immunoglobulin G (IgG) targeting G-protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f4d386f4507bf6e1c6d4cba728a2be

Stat1 nuclear translocation by nucleolin upon monocyte differentiation.

Autor: Uwe Jerke, Sergey Tkachuk, Julia Kiyan, Victoria Stepanova, Angelika Kusch, Michael Hinz, Rainer Dietz, Hermann Haller, Bianca Fuhrman, Inna Dumler

Publikováno v: PLoS ONE, Vol 4, Iss 12, p e8302 (2009)

BACKGROUND:Members of the signal transducer and activator of transcription (Stat) family of transcription factors traverse the nuclear membrane through a specialized structure, called the nuclear pore complex (NPC), which represents a selective filte

Externí odkaz: https://doaj.org/article/faa4eeef3dbd431c8303e80f4f9f83fc

Sex differences in exercise-induced physiological myocardial hypertrophy are modulated by oestrogen receptor beta

Autor: Jan-Åke Gustafsson, Christina Westphal, Renée Ventura-Clapier, Carola Schubert, Joachim Leber, Maryline Moulin, Elke Dworatzek, Vera Regitz-Zagrosek, Angelika Kusch, Duska Dragun, Daniela Fliegner, Shokoufeh Mahmoodzadeh, Mercy M. Davidson, Georgios Kararigas

Publikováno v: Cardiovascular Research. 102:418-428

Aims Oestrogen receptor alpha (ERα) and beta (ERβ) are involved in the regulation of pathological myocardial hypertrophy (MH). We hypothesize that both ER are also involved in physiological MH. Therefore, we investigated the role of ER in exercise-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8bd2103ae6a4b359ef56269ca041f54
https://doi.org/10.1093/cvr/cvu065

Abstract 270: mTORC1 is Essential for Cardiomyocyte Homeostasis and Female Sex Related Cardioprotection

Autor: Nelli Beiner, Melanie Boerries, Marijke Brink, Angelika Kusch, Tobias B. Huber, Hauke Busch, Rusan Catar, Florian Grahammer, Thorsten Mielke, Duska Dragun, Dennis Guergen, Joern Dengjel

Publikováno v: Circulation Research. 119

Mechanistic target of rapamycin (mTOR) kinase operates in two functionally and structurally distinct protein complexes mTORC1 and mTORC2. Raptor is a defining mTORC1 protein critical for cardiac growth in response to stress. Our previous studies show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dcbe2baf2c52ddef3bfa87237877881b
https://doi.org/10.1161/res.119.suppl_1.270