Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Angelika, Hilderink"'
Autor:
Patrick Niekamp, Felix Scharte, Tolulope Sokoya, Laura Vittadello, Yeongho Kim, Yongqiang Deng, Elisabeth Südhoff, Angelika Hilderink, Mirco Imlau, Christopher J. Clarke, Michael Hensel, Christopher G. Burd, Joost C. M. Holthuis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Activation of ESCRT prevents potentially lethal outcomes of minor perturbations in lysosomal integrity. Here authors show that Ca2 + -activated scrambling of sphingomyelin and its cytosolic turnover drives lysosomal repair independently of ESCRT.
Externí odkaz:
https://doaj.org/article/8782aaf4d7804bac8f2c73df7fa64a62
Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway
Autor:
Tolulope Sokoya, Jan Parolek, Mads Møller Foged, Dmytro I Danylchuk, Manuel Bozan, Bingshati Sarkar, Angelika Hilderink, Michael Philippi, Lorenzo D Botto, Paulien A Terhal, Outi Mäkitie, Jacob Piehler, Yeongho Kim, Christopher G Burd, Andrey S Klymchenko, Kenji Maeda, Joost CM Holthuis
Publikováno v:
eLife, Vol 11 (2022)
Sphingomyelin is a dominant sphingolipid in mammalian cells. Its production in the trans-Golgi traps cholesterol synthesized in the ER to promote formation of a sphingomyelin/sterol gradient along the secretory pathway. This gradient marks a fundamen
Externí odkaz:
https://doaj.org/article/420811a13b754b8b97db2aafb7c04c32
Autor:
Svenja Bockelmann, JohnG.M. Mina, Sergei Korneev, Dina G. Hassan, Dagmar Müller, Angelika Hilderink, Hedwich C. Vlieg, Reinout Raijmakers, AlbertJ.R. Heck, Per Haberkant, JoostC.M. Holthuis
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 3, Pp 515-530 (2018)
Ceramides are central intermediates of sphingolipid metabolism with dual roles as mediators of cellular stress signaling and mitochondrial apoptosis. How ceramides exert their cytotoxic effects is unclear and their poor solubility in water hampers a
Externí odkaz:
https://doaj.org/article/5fbde1ea7ab742f59e3b86c8480d4684
Autor:
Matthijs Kol, Radhakrishnan Panatala, Mirjana Nordmann, Leoni Swart, Leonie van Suijlekom, Birol Cabukusta, Angelika Hilderink, Tanja Grabietz, John G.M. Mina, Pentti Somerharju, Sergei Korneev, Fikadu G. Tafesse, Joost C.M. Holthuis
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 5, Pp 962-973 (2017)
SM is a fundamental component of mammalian cell membranes that contributes to mechanical stability, signaling, and sorting. Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, a reaction catalyzed by SM synt
Externí odkaz:
https://doaj.org/article/7063de174e69443c96844c17cd5ebd93
Autor:
Matthijs Kol, Radhakrishnan Panatala, Mirjana Nordmann, Leoni Swart, Leonie van Suijlekom, Birol Cabukusta, Angelika Hilderink, Tanja Grabietz, John G.M. Mina, Pentti Somerharju, Sergei Korneev, Fikadu G. Tafesse, Joost C.M. Holthuis
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 7, Pp 1273-1285 (2016)
SM is a fundamental component of mammalian cell membranes that contributes to mechanical stability, signaling, and sorting. Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, a reaction catalyzed by SM synt
Externí odkaz:
https://doaj.org/article/f750aa0450d64a23921c6eb4b124c2ef
Autor:
Jan Parolek, Tolulope Sokoya, Mads Møller Foged, Dmytro I Danylchuk, Manuel Bozan, Bingshati Sarkar, Angelika Hilderink, Michael Philippi, Lorenzo D Botto, Paulien A Terhal, Outi Mäkitie, Jacob Piehler, Yeongho Kim, Christopher G Burd, Andrey S Klymchenko, Kenji Maeda, Joost CM Holthuis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b3b8f5b0c08c7aceceaf696cda617c3
https://doi.org/10.7554/elife.79278.sa2
https://doi.org/10.7554/elife.79278.sa2
Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway
Autor:
Jan Parolek, Tolulope Sokoya, Mads Møller Foged, Dmytro I Danylchuk, Manuel Bozan, Bingshati Sarkar, Angelika Hilderink, Michael Philippi, Lorenzo D Botto, Paulien A Terhal, Outi Mäkitie, Jacob Piehler, Yeongho Kim, Christopher G Burd, Andrey S Klymchenko, Kenji Maeda, Joost CM Holthuis
Publikováno v:
eLife. 11
Sphingomyelin is a dominant sphingolipid in mammalian cells. Its production in the trans-Golgi traps cholesterol synthesized in the ER to promote formation of a sphingomyelin/sterol gradient along the secretory pathway. This gradient marks a fundamen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d47d2e813e9c6831e27915084a83f15
https://pubmed.ncbi.nlm.nih.gov/36102623
https://pubmed.ncbi.nlm.nih.gov/36102623
Autor:
Patrick, Niekamp, Felix, Scharte, Tolulope, Sokoya, Laura, Vittadello, Yeongho, Kim, Yongqiang, Deng, Elisabeth, Südhoff, Angelika, Hilderink, Mirco, Imlau, Christopher J, Clarke, Michael, Hensel, Christopher G, Burd, Joost C M, Holthuis
Publikováno v:
Nature communications. 13(1)
Lysosomes are vital organelles vulnerable to injuries from diverse materials. Failure to repair or sequester damaged lysosomes poses a threat to cell viability. Here we report that cells exploit a sphingomyelin-based lysosomal repair pathway that ope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::71b1f73979ae3e2298731237ae1ace5d
https://pubmed.ncbi.nlm.nih.gov/35388011
https://pubmed.ncbi.nlm.nih.gov/35388011
Autor:
Mirco Imlau, Laura Vittadello, Yongqiang Deng, Christopher J. Clarke, Angelika Hilderink, Tolulope Sokoya, Joost C. M. Holthuis, Christopher G. Burd, Patrick Niekamp, Yeongho Kim
Lysosomes are vital organelles vulnerable to injuries from diverse materials. Failure to repair or sequester damaged lysosomes poses a threat to cell viability. Here we report that cells exploit a sphingomyelin-based lysosomal repair pathway that ope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0230507bf0b449c8e04253c355aa4ba9
https://doi.org/10.1101/2021.03.12.435146
https://doi.org/10.1101/2021.03.12.435146
Autor:
Birol, Cabukusta, Niclas T, Nettebrock, Matthijs, Kol, Angelika, Hilderink, Fikadu G, Tafesse, Joost C M, Holthuis
Publikováno v:
Bioscience Reports
Ceramides are essential precursors of sphingolipids with a dual role as mediators of apoptotic cell death. Previous work revealed that the ER-resident ceramide phosphoethanolamine (CPE) synthase SMSr/SAMD8 is a suppressor of ceramide-mediated apoptos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33993930659356ebf784831df14719ce
https://pubmed.ncbi.nlm.nih.gov/28659495
https://pubmed.ncbi.nlm.nih.gov/28659495