Methylglyoxal induces p53 activation and inhibits mTORC1 in human umbilical vein endothelial cells

Autor: Xinmiao Zhang, Angelica Rodriguez-Niño, Diego O. Pastene, Prama Pallavi, Jacob van den Born, Stephan J. L. Bakker, Bernhard K. Krämer, Benito A. Yard

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Methylglyoxal (MGO), a precursor of advanced glycation end products (AGEs), is regarded as a pivotal mediator of vascular damage in patients with diabetes. We have previously reported that MGO induces transcriptional changes compatible with

Externí odkaz: https://doaj.org/article/6ec653575d044273a6fd2d3553d72164

Serum Carnosinase-1 and Albuminuria Rather than the CNDP1 Genotype Correlate with Urinary Carnosinase-1 in Diabetic and Nondiabetic Patients with Chronic Kidney Disease

Autor: Angelica Rodriguez-Niño, Sibylle J. Hauske, Anna Herold, Jiedong Qiu, Jacob van den Born, Stephan J. L. Bakker, Bernhard K. Krämer, Benito A. Yard

Publikováno v: Journal of Diabetes Research, Vol 2019 (2019)

Background. Carnosinase-1 (CN-1) can be detected in 24 h urine of healthy individuals and patients with type 2 diabetes (T2DM). We aimed to assess whether urinary CN-1 is also reliably measured in spot urine and investigated its association with rena

Externí odkaz: https://doaj.org/article/add3db2bcd574faea57b7f1640156232

Human carnosinase 1 overexpression aggravates diabetes and renal impairment in BTBROb/Ob mice

Autor: Benito A. Yard, Diego O. Pastene, Jiedong Qiu, Stefan Porubsky, Shiqi Zhang, Carolina Delatorre, Bernhard K. Krämer, Harry van Goor, Darya Nosan, Carsten Sticht, Xinmiao Zhang, Thomas Albrecht, Angelica Rodriguez-Niño, Sibylle J. Hauske

Publikováno v: Journal of Molecular Medicine (Berlin, Germany)
Journal of Molecular Medicine, 98(9), 1333-1346. SPRINGER HEIDELBERG

Objective To assess the influence of serum carnosinase (CN1) on the course of diabetic kidney disease (DKD). Methods hCN1 transgenic (TG) mice were generated in a BTBROb/Ob genetic background to allow the spontaneous development of DKD in the presenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86db08c3ffee4b21578739fa825a38b0
https://doi.org/10.1007/s00109-020-01957-0

Carnosinase concentration, activity, and CNDP1 genotype in patients with type 2 diabetes with and without nephropathy

Autor: Verena Peters, Angelica Rodriguez-Niño, Claus Peter Schmitt, Stephan J. L. Bakker, Jiedong Qiu, Jacob van den Born, Benito A. Yard, Peter Schnuelle, Thomas Albrecht, Bernhard K. Krämer, Alexander Lammert, Shiqi Zhang, Sibylle J. Hauske

Publikováno v: Amino Acids, 31(4), 611-617. SPRINGER WIEN

This study assessed if serum carnosinase (CNDP1) activity and concentration in patients with type 2 diabetes mellitus (T2D) with diabetic nephropathy (DN) differs from those without nephropathy. In a cross-sectional design 127 patients with T2D with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7166317e23fe62755321ee3df3dc2f
https://doi.org/10.1007/s00726-018-02692-0

Meat intake and risk of mortality and graft failure in kidney transplant recipients

Autor: M. Yusof Said, António W Gomes-Neto, Adrian Post, Marco van Londen, Joëlle C Schutten, Stephan J. L. Bakker, Pim de Blaauw, Lyanne M. Kieneker, Ilja M. Nolte, M. Rebecca Heiner-Fokkema, Benito A. Yard, Jennifer van der Krogt, Karin J Borgonjen-van den Berg, Else van den Berg, Gerjan Navis, Angelica Rodriguez-Niño, Maryse C J Osté

Publikováno v: American Journal of Clinical Nutrition 114 (2021) 4
American Journal of Clinical Nutrition, 114(4), 1505-1517
The American Journal of Clinical Nutrition
American Journal of Clinical Nutrition, 114(4):nqab185, 1505-1517. Oxford University Press

Background: It is unknown whether meat intake is beneficial for long-term patient and graft survival in kidney transplant recipients (KTR).Objectives: We first investigated the association of the previously described meat intake biomarkers 1-methylhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4eedf2f98f61cd19213b0494d7b922
https://research.wur.nl/en/publications/meat-intake-and-risk-of-mortality-and-graft-failure-in-kidney-tra