The adiponectin‐derived peptide ALY688 protects against the development of metabolic dysfunction‐associated steatohepatitis

Autor: Zhe Huang, Hye Kyoung Sung, Xingqun Yan, Shiyu He, Leigang Jin, Qin Wang, Xuerui Wu, Henry H. Hsu, Angelica Pignalosa, Kathryn Crawford, Gary Sweeney, Aimin Xu

Publikováno v: Clinical and Translational Science, Vol 17, Iss 6, Pp n/a-n/a (2024)

Abstract Metabolic dysfunction‐associated steatohepatitis (MASH) is the severe form of non‐alcoholic fatty liver disease which has a high potential to progress to cirrhosis and hepatocellular carcinoma, yet adequate effective therapies are lackin

Externí odkaz: https://doaj.org/article/c03d45ca6ff64906874b9a5986c035b2

Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity

Autor: Shin J. Lee, Graciela Sanchez-Watts, Jean-Philippe Krieger, Angelica Pignalosa, Puck N. Norell, Alyssa Cortella, Klaus G. Pettersen, Dubravka Vrdoljak, Matthew R. Hayes, Scott Kanoski, Wolfgang Langhans, Alan G. Watts

Publikováno v: Molecular Metabolism, Vol 11, Iss , Pp 33-46 (2018)

Objective: Glucagon-like peptide-1 (GLP-1) neurons in the hindbrain densely innervate the dorsomedial hypothalamus (DMH), a nucleus strongly implicated in body weight regulation and the sympathetic control of brown adipose tissue (BAT) thermogenesis.

Externí odkaz: https://doaj.org/article/9dcbfeec504a41b4b09b7e1e56325d6d

High-lard and high-fish-oil diets differ in their effects on function and dynamic behaviour of rat hepatic mitochondria.

Autor: Lillà Lionetti, Maria Pina Mollica, Immacolata Donizzetti, Giorgio Gifuni, Raffaella Sica, Angelica Pignalosa, Gina Cavaliere, Marcello Gaita, Chiara De Filippo, Antonio Zorzano, Rosalba Putti

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e92753 (2014)

Mitochondria are dynamic organelles that frequently undergo fission and fusion processes, and imbalances in these processes may be involved in obesity and insulin resistance.The present work had the following aims: (a) to evaluate whether the mitocho

Externí odkaz: https://doaj.org/article/45f5a6ae7cee46e2aaf5bc2a5e622a71

Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain

Autor: Macarena Vergara, Danielle Quinn, Seth Anderson, Rebecca Darling, Molly McDougle, Myrtha Arnold, Guillaume de Lartigue, Benjamin Zollinger, Shin J. Lee, Angelica Pignalosa, Emilie J. Simonnet, Annabeth Pan, Arashdeep Singh, Wolfgang Langhans, Alan de Araujo, Helen E. Raybould, Jean-Philippe Krieger

Publikováno v: Cell Reports, 30 (6)
Cell Reports, Vol 30, Iss 6, Pp 2028-2039.e4 (2020)
Cell reports, vol 30, iss 6
Cell reports

SUMMARY The vagus nerve conveys gastrointestinal cues to the brain to control eating behavior. In obesity, vagally mediated gut-brain signaling is disrupted. Here, we show that the cocaine- and amphetamine-regulated transcript (CART) is a neuropeptid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea3165e2800feb50f0e800b52ff8779
https://hdl.handle.net/20.500.11850/400873

Differential Effects of High-Fish Oil and High-Lard Diets on Cells and Cytokines Involved in the Inflammatory Process in Rat Insulin-Sensitive Tissues

Autor: Giorgio Gifuni, Angelica Pignalosa, Immacolata Donizzetti, Maria Pina Mollica, Raffaella Sica, Lillà Lionetti, Gina Cavaliere, Rosalba Putti

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 15; Issue 2; Pages: 3040-3063
International Journal of Molecular Sciences, Vol 15, Iss 2, Pp 3040-3063 (2014)

Dietary fat sources may differentially affect the development of inflammation in insulin-sensitive tissues during chronic overfeeding. Considering the anti-inflammatory properties of ω-3 fatty acids, this study aimed to compare the effects of chroni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318f4f5359e0c9e4ff871093248fc40e
http://europepmc.org/articles/PMC3958898