Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Angelica M. Bello"'
Autor:
Lakshmi P. Kotra, Ewa Wasilewski, Shannon E. Dunn, Angelica M. Bello, Elizabeth J. Curiel Tejeda, Adam Koebel
Publikováno v:
Journal of Medicinal Chemistry. 60:8876-8887
Peptidyl arginine deiminases have been shown to be hyperactive in neurodegenerative diseases including multiple sclerosis. An α-amino acid-based core structure, derived from a hydantoin core, with unique heterocycles on the side chains were synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0185780e7119f983456ed1599bb131e
https://doi.org/10.1021/acs.jmedchem.7b01102
https://doi.org/10.1021/acs.jmedchem.7b01102
Autor:
Angelica M. Bello, Ewa Wasilewski, Hance Clarke, Melissa Maureen Lewis, Yi Yang, Lakshmi P. Kotra
Publikováno v:
Cannabis and Cannabinoid Research
Introduction: Cannabis sativa (hemp) seeds are popular for their high nutrient content, and strict regulations are in place to limit the amount of potentially harmful phytocannabinoids, especially Δ9-tetrahydrocannabinol (Δ9-THC). In Canada, this l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9ddce04df90a29684b3e80ffeb6298
http://europepmc.org/articles/PMC5665515
http://europepmc.org/articles/PMC5665515
Autor:
Angelica M. Bello, Amit Sarswat, Andrew V. Caprariello, Chithra M. Muthuramu, Lakshmi P. Kotra, Sai Kumar Chakka, Ewa Wasilewski, Shannon E. Dunn, Peter K. Stys
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:2643-2656
Protein arginine deiminases (PAD) are implicated in a variety of inflammatory and neurodegenerative diseases including multiple sclerosis (MS). Following the discovery of an in silico hit containing hydantoin and a piperidine moiety, we hypothesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956c87f1213d1dffc54c5b327fc1a494
https://doi.org/10.1016/j.bmc.2017.03.006
https://doi.org/10.1016/j.bmc.2017.03.006
Autor:
Melissa Maureen Lewis, Beata Majchrzak-Kita, Noruê Salum, Angelica M. Bello, Eleanor N. Fish, Lakshmi P. Kotra, Lianhu Wei
Publikováno v:
Journal of Interferon & Cytokine Research. 36:180-191
Type I interferons (IFNs) exhibit broad-spectrum antiviral activity, with potential utility against emerging acute virus infections that pose a threat to global health. Recombinant IFN-αs that have been approved for clinical use require cold storage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc14432d65f096366f2c6b600f83e6d
https://doi.org/10.1089/jir.2015.0123
https://doi.org/10.1089/jir.2015.0123
Autor:
Angelica M. Bello, Mohd Asad, Sourabh Mundra, Sumit Rathore, Radhakrishnan Mahesh, Lakshmi P. Kotra, Pawan Malhotra, Jane Yang, Lianhu Wei, Asif Mohmmed, Sai Kumar Chakka, Vandana Thakur
Publikováno v:
Bioorganicmedicinal chemistry. 25(20)
The prokaryotic ATP-dependent ClpP protease, localized in the relict plastid of malaria parasite, represents a potential drug target. In the present study, we utilized in silico structure-based screening and medicinal chemistry approaches to identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e6e265f8ee42ef876f2c55213d1473
https://pubmed.ncbi.nlm.nih.gov/28917450
https://pubmed.ncbi.nlm.nih.gov/28917450
Autor:
Sai Kumar Chakka, Yulia Katsman, Noruê Salum, Angelica M. Bello, Iain Scovell, Madeleine C. Bareau, Donald R. Branch, Anton Neschadim, Lakshmi P. Kotra, Meena K. Purohit
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:2739-2752
Idiopathic or immune thrombocytopenia (ITP) is a serious clinical disorder involving the destruction of platelets by macrophages. Small molecule therapeutics are highly sought after to ease the burden on current therapies derived from human sources.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80802e9f45f15f10b79dc45d50509b92
https://doi.org/10.1016/j.bmc.2014.03.016
https://doi.org/10.1016/j.bmc.2014.03.016
Autor:
Beata Majchrzak-Kita, Noruê Salum, Angelica M. Bello, Eleanor N. Fish, Meena K. Purohit, Lianhu Wei, Lakshmi P. Kotra
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:978-985
Small molecules that mimic IFN-α epitopes that interact with the cell surface receptor, IFNAR, would be useful therapeutics. One such 8-amino acid region in IFN-α2, designated IRRP-1, was used to derive 11 chemical compounds that belong to 5 distin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da40b38d2ae304c6879d58625e4bada7
https://doi.org/10.1016/j.bmc.2013.12.049
https://doi.org/10.1016/j.bmc.2013.12.049
Autor:
Emil F. Pai, Ian Crandall, Angelica M. Bello, Maria Elena Meza-Aviña, Ewa Poduch, Kevin C. Kain, Lakshmi P. Kotra, Yan Liu, Melissa Maureen Lewis, Lianhu Wei, Christopher J. Paige
Publikováno v:
Journal of Medicinal Chemistry. 54:2891-2901
Fluorinated nucleosides and nucleotides are of considerable interest to medicinal chemists because of their antiviral, anticancer, and other biological activities. However, their direct interactions at target binding sites are not well understood. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66df55236b962982a7528b236f57077
https://doi.org/10.1021/jm101642g
https://doi.org/10.1021/jm101642g
Autor:
Beata Majchrzak-Kita, Eleanor N. Fish, Lianhu Wei, Angelica M. Bello, Lakshmi P. Kotra, Tanushree Bende, Xiaoyang Wang
Publikováno v:
Journal of Medicinal Chemistry. 51:2734-2743
Type 1 interferons (IFN) bind specifically to the corresponding receptor, IFNAR. Agonists and antagonists for IFNAR have potential therapeutic value in the treatment of viral infections and systemic lupus erythematosus, respectively. Specific sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a23c1eeb10269eaa6bb186816efb497
https://doi.org/10.1021/jm701182y
https://doi.org/10.1021/jm701182y
Autor:
Emil F. Pai, Xiaoyang Wang, Kevin C. Kain, Lakshmi P. Kotra, Ewa Poduch, Angelica M. Bello, Christopher Dyanand, Yan Liu, Ian Crandall, Lianhu Wei
Publikováno v:
Journal of Medicinal Chemistry. 51:439-448
Malaria, caused by Plasmodia parasites, has re-emerged as a major problem, imposing its fatal effects on human health, especially due to multidrug resistance. In Plasmodia, orotidine 5'-monophosphate decarboxylase (ODCase) is an essential enzyme for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fabec1e39e80dd21a36e2109ef8f6862
https://doi.org/10.1021/jm7010673
https://doi.org/10.1021/jm7010673